Protein Alignment Muc11A and MUC1

DIOPT Version :9

• Sequence 1: NP_001285150.1
• Gene: Muc11A / 32174
• FlyBaseID: FBgn0052656
• Length: 1552
• Species: Drosophila melanogaster
• Sequence 2: NP_001358649.1
• Gene: MUC1 / 4582
• HGNCID: 7508
• Length: 1230
• Species: Homo sapiens
• Alignment Length: 1112
• Identity: 419/1112 - (37%)
• Similarity: 530/1112 - (47%)
• Gaps: 219/1112 - (19%)

  Fly   147 TQIP----LETTQVAVETTQIPLETTQASG--ETTTAAIEET--TTGSEAPLEPESTVPSDTTPV 203
            ||.|    |..|.:...|...|......||  .:|....:||  |..|..|...|....|.|:.|
Human     5 TQSPFFLLLLLTVLTATTAPKPATVVTGSGHASSTPGGEKETSATQRSSVPSSTEKNAVSMTSSV 69

  Fly   204 DSTLAPG-----WEGTYPTIEPNT-PAEDPNAPAGTTLAPGEVDPNSPIDPNSPLDPNAPEESTN 262
            .|:.:||     .:|...|:.|.| ||      :|:....|:...:.|:               .
Human    70 LSSHSPGSGSSTTQGQDVTLAPATEPA------SGSAATWGQDVTSVPV---------------T 113

  Fly   263 EPGLVDPTLPA-DTTTAPDS-PVEGSSAAPG---TPADVTTAAPG--AP-ADGSSAAPGS-PADG 318
            .|.|...|.|| |.|:|||: |..||:|.|.   |.|..|..|||  || |.|.::||.: ||.|
Human   114 RPALGSTTPPAHDVTSAPDNKPAPGSTAPPAHGVTSAPDTRPAPGSTAPQAHGVTSAPDTRPAPG 178

  Fly   319 SSAAPGSPADVTTAAPGAPADGSSAAPGAPADGSSAAPGSPADVTTAAPG--AP-ADGSSAAPGS 380
            |:|.|..  .||:|....||.||:|   .||.|.::||.     |..|||  || |.|.::||.:
Human   179 STAPPAH--GVTSAPDTRPAPGSTA---PPAHGVTSAPD-----TRPAPGSTAPAAHGVTSAPDT 233

  Fly   381 -PAEGSSAAPGAPADVTTAAPGAPADGSSAAPGAPADGSSAAPGSPADVTTAAPGA---PADGSS 441
             ||.||: ||.|.. ||:|....||.||:|   .||.|.::||.     |..|||:   ||.|.:
Human   234 RPAPGST-APQAHG-VTSAPDTRPAPGSTA---PPAHGVTSAPD-----TRPAPGSTAPPAHGVT 288

  Fly   442 AAPGS-PAEGSSAAPGAPADVTTAAPGAPADGSSAAPGA----PADGSSAAPGSPA----DVTTA 497
            :||.: ||.||:|.|.  ..||:|....||.||: ||.|    .|..|..||||.|    .||:|
Human   289 SAPDTRPAPGSTAPPA--HGVTSAPESRPAPGST-APAAHGVTSAPESRPAPGSTAPAAHGVTSA 350

  Fly   498 APGAPADGSSAAPGAPADGSSAAPGSPADVTTAAPGA---PADGSSAAPGSPAEESSAAPGSPAD 559
            ....||.||:|   .||.|.::||.     |..|||:   ||.|.::||.:.....|.||  ||.
Human   351 PESRPAPGSTA---PPAHGVTSAPD-----TRPAPGSTAPPAHGVTSAPDTRPAPGSTAP--PAH 405

  Fly   560 VTTAAPGA-PADGSSAAPGAPADGSSAAPGSPADVTTAAPGA---PADGSSAAPGS-PAEGSSAA 619
            ..|:||.. ||.||:|   .||.|.::||.     |..|||:   ||.|.::||.| ||.||:|.
Human   406 GVTSAPDTRPAPGSTA---PPAHGVTSAPD-----TRPAPGSTAPPAHGVTSAPESRPAPGSTAP 462

  Fly   620 PGAPADVTTAAPGAPADGSSAAPGA----PADGSSAAPGSPA----DVTTAAPGAPADGSSA--- 673
            |.  ..||:|....||.||: ||.|    .|..|..||||.|    .||:|....||.||:|
Human   463 PA--HGVTSAPESRPAPGST-APAAHGVTSAPESRPAPGSTAPAAHGVTSAPESRPAPGSTAPRA 524

  Fly   674 -----APGA-PADGSSAAPGSPADVTTAAPGAPADGSSAAPGSPAEGSSAAPGSPADVTTAAPGA 732
                 ||.. ||.||:|.|..  .||:|....||.||:|   .||.|.::||.     |..|||:
Human   525 HGVTSAPDTRPAPGSTAPPAH--GVTSAPDTRPAPGSTA---PPAHGVTSAPD-----TRPAPGS 579

  Fly   733 ---PADGSSAAPGA-PADGSSAAPGSPADVTTAAPGAPADGSSAAPGSPADVTTAAPGAPADGSS 793
               ||.|.::||.. ||.||:|.|..  .||:|....||.||:|.|..  .||:|....||.||:
Human   580 TAPPAHGVTSAPDTRPAPGSTAPPAH--GVTSAPDTRPAPGSTAPPAH--GVTSAPDTRPAPGST 640

  Fly   794 AAPGSPAEGSSAAPGSPADVTTAAPGAPADGSSAAPGAPADGSSAAPGSPA----DVTTAAPGAP 854
            |   .||.|.::||.     |..|||:.|..:.....||.  |..||||.|    .||:|....|
Human   641 A---PPAHGVTSAPD-----TRPAPGSTAPAAHGVTSAPE--SRPAPGSTAPAAHGVTSAPESRP 695

  Fly   855 ADGSSAAPG---------APADGSSAAPGSPADVTTAAPGAPADGSSAAPGSPADVTTAAPGAPA 910
            |.||:|.|.         .||.||:|.|..  .||:|....||.||:|.|..  .||:|....||
Human   696 APGSTAPPAHGVTSAPDTRPAPGSTAPPAH--GVTSAPDTRPAPGSTAPPAH--GVTSAPDTRPA 756

  Fly   911 DGSSAAPGSPAEGSSAAPGAPADVTTAAPGA---PADGSSAAPGA-PADGSSAAPGSPADVTTAA 971
            .||:|   .||.|.::||.     |..|||:   ||.|.::||.. ||.||:|.|..  .||:|.
Human   757 PGSTA---PPAHGVTSAPD-----TRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAH--GVTSAP 811

  Fly   972 PGAPADGSSAAPGAPADVTTAAPGAPADGSSAAPGSPAEGSSAAPGAPADVTTAAPGA---PADG 1033
            ...||.||:|.|.  ..||:|....||.||:|   .||.|.::||.     |..|||:   ||.|
Human   812 DTRPAPGSTAPPA--HGVTSAPDTRPAPGSTA---PPAHGVTSAPD-----TRPAPGSTAPPAHG 866

  Fly  1034 SSAAPGA-PADGSSAAPGS---PADVTTAAPGA-PADGSSAAPGSPADVTTAAPGAPADGSSAAP 1093
            .::||.. .|.||:.||||   ||...|:||.. ||.||:|.|..  .||:|....||.||:|.|
Human   867 VTSAPDTRRAPGSTPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAH--GVTSAPDNRPALGSTAPP 929

  Fly  1094 ---GSPAEGSPPAGGSPA-----GSNVPAGGDPADSNVPAGGAPADSNVPAGGAPADSNVPAGGA 1150
               .:.|.||  |.||.:     |::..|...||..:.|.......|:.|...|...:...| .:
Human   930 VHNVTSASGS--ASGSASTLVHNGTSARATTTPASKSTPFSIPSHHSDTPTTLASHSTKTDA-SS 991

  Fly  1151 PADSNVP 1157
            ...|.||
Human   992 THHSTVP 998

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Muc11A	NP_001285150.1	PRK07764	<366..816	CDD:236090	201/494 (41%)
		PRK07764	<696..1109	CDD:236090	176/449 (39%)
		CBM_14	1495..1547	CDD:279884
MUC1	NP_001358649.1	PRK07003	<92..437	CDD:235906	155/406 (38%)
		PHA03247	<276..826	CDD:223021	244/613 (40%)
		PRK12323	<758..982	CDD:237057	94/247 (38%)
		SEA	1009..1127	CDD:214554

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	368	1.000	Domainoid score	I919
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	368	1.000	Inparanoid score	I2155
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40547
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.960