DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Muc11A and COL1A1

DIOPT Version :9

Sequence 1:	NP_001285150.1	Gene:	Muc11A / 32174	FlyBaseID:	FBgn0052656	Length:	1552	Species:	Drosophila melanogaster
Sequence 2:	NP_000079.2	Gene:	COL1A1 / 1277	HGNCID:	2197	Length:	1464	Species:	Homo sapiens

Alignment Length:	1691	Identity:	460/1691 - (27%)
Similarity:	573/1691 - (33%)	Gaps:	500/1691 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 RLLVLLVLTALVASHQAHAAAVGLKCGGKSAVCV-GPLSYQQCVDDLTTGPVVPCALNTRCVTD- 70
            |||:||..|||:...|......|.........|| ..|.|.    |.......||.:   ||.|
Human     8 RLLLLLAATALLTHGQEEGQVEGQDEDIPPITCVQNGLRYH----DRDVWKPEPCRI---CVCDN 65

  Fly    71 GLEICVPVKSAAEAPTAAVAKMVTITDSPVVSESAPLVDSTNSGSGVEISTEGAPASAVPTKPSI 135
            |..:|                     |..:..|                 |:..|.:.||.....
Human    66 GKVLC---------------------DDVICDE-----------------TKNCPGAEVPEGECC 92

  Fly   136 PVETTQAPVETTQIPLETTQVAVETTQIPLETTQASGETTTAAIEETTTGSEAPLEPESTVPSDT 200
            ||                                            ...|||:|.:.|:|
Human    93 PV--------------------------------------------CPDGSESPTDQETT----- 108

  Fly   201 TPVDSTLAPGWEGTYPTIEPNTPAEDPNAPAGTTLAPGEVDPNSPIDPNSPLDPNAP-------- 257
                     |.||......|..| ..|..|.|....||:  |..|..|..|..|..|
Human   109 ---------GVEGPKGDTGPRGP-RGPAGPPGRDGIPGQ--PGLPGPPGPPGPPGPPGLGGNFAP 161

  Fly   258 -------EEST---NEPGLVDPTLPADTTTAPDSP-VEGSSAAPGTPADVTTAAPGAPA------ 305
                   |:||   :.||.:.|:.|......|.:| .:|....||.|.:...:.|..|.
Human   162 QLSYGYDEKSTGGISVPGPMGPSGPRGLPGPPGAPGPQGFQGPPGEPGEPGASGPMGPRGPPGPP 226

  Fly   306 -----DGSSAAPGSPAD----GSSAAPGSPADVTTAAPG-----------------APADGSSAA 344
                 ||.:..||.|.:    |...|.|.|.  |...||                 .|| |....
Human   227 GKNGDDGEAGKPGRPGERGPPGPQGARGLPG--TAGLPGMKGHRGFSGLDGAKGDAGPA-GPKGE 288

  Fly   345 PGAPADGSSAAPGS------PADVTTAAPGAPA-------DGSSAAPGSPA-EGSSAAPGAPADV 395
            ||:|  |.:.|||.      |.:  ...||||.       ||::.|.|.|. .|.:..||.|..|
Human   289 PGSP--GENGAPGQMGPRGLPGE--RGRPGAPGPAGARGNDGATGAAGPPGPTGPAGPPGFPGAV 349

  Fly   396 TT---AAPGAP-----ADGSSAAPGAPADGSSAAP-GSPADVTTAAPGAP-ADGSSAAPGSPAEG 450
            ..   |.|..|     ..|....||.|....:|.| |:|     .|.|.| |.|::.|||  ..|
Human   350 GAKGEAGPQGPRGSEGPQGVRGEPGPPGPAGAAGPAGNP-----GADGQPGAKGANGAPG--IAG 407

  Fly   451 SSAAPGAPADVTTAAPGAP--ADGSSAAPGAP-ADGSSAAPGSPADVTTAAPGAPA--DGSSAAP 510
            :...|||........||.|  ..|:|..|||| :.|.:.|.|.|..|....|..||  :|...|.
Human   408 APGFPGARGPSGPQGPGGPPGPKGNSGEPGAPGSKGDTGAKGEPGPVGVQGPPGPAGEEGKRGAR 472

  Fly   511 GAPADGSSAAPGSPADVTTAAPGA----PADGSSAAPGSPAEESSAAPGSPADVTTAAPG-APAD 570
            |.|  |.:..||.|.:  ...||:    .|||.:...|...|..|..|..|    ..:|| |...
Human   473 GEP--GPTGLPGPPGE--RGGPGSRGFPGADGVAGPKGPAGERGSPGPAGP----KGSPGEAGRP 529

  Fly   571 GSSAAPGAPADGSSAAPGSPA-DVTTAAPG-APADGSSAAPGSP-AEGSSAAPGAPADVTTAAPG 632
            |.:..||  |.|.:.:||||. |..|..|| |..||....||.| |.|.:...|.|.  ...|.|
Human   530 GEAGLPG--AKGLTGSPGSPGPDGKTGPPGPAGQDGRPGPPGPPGARGQAGVMGFPG--PKGAAG 590

  Fly   633 APAD-GSSAAPGAPA-------DGSSAAPGSPADVTTAAPGAPA-----DGSSAAPG-----APA 679
            .|.. |....||.|.       ||.:.|.|.|      .|..||     .|.:.:||     .||
Human   591 EPGKAGERGVPGPPGAVGPAGKDGEAGAQGPP------GPAGPAGERGEQGPAGSPGFQGLPGPA 649

  Fly   680 --DGSSAAPGS---PADVTTAAPGAPADGSSAAPGSPAEGSSAAPGSPADVTTAAPGAP----AD 735
              .|.:..||.   |.|:  .|||  ..|:....|.|.|.....|..||. ...|.|||    |.
Human   650 GPPGEAGKPGEQGVPGDL--GAPG--PSGARGERGFPGERGVQGPPGPAG-PRGANGAPGNDGAK 709

  Fly   736 GSSAAPGAPADGSSAAPGSPADVTTAAPGAPAD-GSSAAPGSPADVTTAAPGAPADGSSAAPGSP 799
            |.:.|||||  ||..|||        ..|.|.: |::..||...|...|.|.. ||||....|..
Human   710 GDAGAPGAP--GSQGAPG--------LQGMPGERGAAGLPGPKGDRGDAGPKG-ADGSPGKDGVR 763

  Fly   800 AEGSSAAPGSPADVTTAAPGAPADGSSAAPGAPADGSSAAPGSPADVTTAAPGAPADGSSAAPGA 864
            .......|..||       |||.|...:.|..|| |.:.|.|:|.|.....|..|| |.:..||
Human   764 GLTGPIGPPGPA-------GAPGDKGESGPSGPA-GPTGARGAPGDRGEPGPPGPA-GFAGPPG- 818

  Fly   865 PADGSSAAPGSPADVTTAAPGAPADGSSAAPGSPADVTTAAPGAPADGSSAAPGSP-AEGSSAAP 928
             |||...|.|.|.|.     ||..|.....|..|     |.|..|. |:..|||:. |.||:..|
Human   819 -ADGQPGAKGEPGDA-----GAKGDAGPPGPAGP-----AGPPGPI-GNVGAPGAKGARGSAGPP 871

  Fly   929 GAPADVTTAAPGAPADGSSAAPGAPADGSSAAPGSPADVTTAAPGAPADGSSAAPGAPADVTTAA 993
            ||     |..|||.  |....||  ..|::..||.|..........|. |.:...|.|.:|....
Human   872 GA-----TGFPGAA--GRVGPPG--PSGNAGPPGPPGPAGKEGGKGPR-GETGPAGRPGEVGPPG 926

  Fly   994 PGAPADGSSAAPGSPAEGSSAAPGAPADVTTAAP----GAPAD-GSSAAPGAPADGSSAAPGSPA 1053
            |..|| |...:||  |:|.:.|||.|.....|..    |.|.. |....||.|  |.|..||...
Human   927 PPGPA-GEKGSPG--ADGPAGAPGTPGPQGIAGQRGVVGLPGQRGERGFPGLP--GPSGEPGKQG 986

  Fly  1054 DVTTAAPGAPADGSSAAPGSPADVTTAAPG-APADGSSAAPGSP-AEGSPPAGGSPAGSNVPAGG 1116
                      ..|:|...|.|..:  ..|| |...|.|...|:| |||||...|||.     |.|
Human   987 ----------PSGASGERGPPGPM--GPPGLAGPPGESGREGAPGAEGSPGRDGSPG-----AKG 1034

  Fly  1117 DPADSNVPAG--GAPADSNVPAGGAPADSNVPAGGAPADSNVPAGGAPADANVPAGGAPADSNVP 1179
            |..::. |||  |||        |||        |||.    |.|        |||    .|...
Human  1035 DRGETG-PAGPPGAP--------GAP--------GAPG----PVG--------PAG----KSGDR 1066

  Fly  1180 GGGAPADANVPAGGAPADSNVPAGGAPAGSNVPAGGAPADSNVPAGGAPADSNVPAGGAPAGSNV 1244
            |...||.   |||        |.|  |.|:..|||......:....|...|..:......:|...
Human  1067 GETGPAG---PAG--------PVG--PVGARGPAGPQGPRGDKGETGEQGDRGIKGHRGFSGLQG 1118

  Fly  1245 PAG--SSPGSSVLGPNPPAGSVVPSIPVLPGGAGSWPWHPRPNIPIVPPTWRPLLPGQNGSGAPG 1307
            |.|  .|||..  ||:..:|...|..|  ||.||:                    ||::|
Human  1119 PPGPPGSPGEQ--GPSGASGPAGPRGP--PGSAGA--------------------PGKDG----- 1154

  Fly  1308 SGLINGIVNPPQRPHPFWPNWQSWVNSWRPTKPVPSTEAPVQPQNPQQPQNPQQPGNSNPETAES 1372
               :||:..|...|.|               :.......||.|..|     |..||...|.:|..
Human  1155 ---LNGLPGPIGPPGP---------------RGRTGDAGPVGPPGP-----PGPPGPPGPPSAGF 1196

  Fly  1373 VEQAAPVPP---------------ANVPASNENASVEDSNKASSEKSKDKPKSGEDQSKEQEQKK 1422
            .....|.||               ||| ..:.:..|:.:.|:.|::.::      .:|.|..:|.
Human  1197 DFSFLPQPPQEKAHDGGRYYRADDANV-VRDRDLEVDTTLKSLSQQIEN------IRSPEGSRKN 1254

  Fly  1423 PSSEEKEKDSKEKNDKDSKEKKDNDSKDKKDKSKEEKDNESQKD-NDGDDEPSSKEKKQYVKDLI 1486
            |:                     ...:|.|....:.|..|...| |.|.:           .|.|
Human  1255 PA---------------------RTCRDLKMCHSDWKSGEYWIDPNQGCN-----------LDAI 1287

  Fly  1487 K---KLKKGDECDEDDVYPDVRDC--RKYYRCEVKKSGKHKFAHLRCDKKERFDWLTQSCVPKDE 1546
            |   .::.|:.|    |||.....  :.:|..:..|..:|.:.........:|::..|...|.|.
Human  1288 KVFCNMETGETC----VYPTQPSVAQKNWYISKNPKDKRHVWFGESMTDGFQFEYGGQGSDPADV 1348

  Fly  1547 A 1547
            |
Human  1349 A 1349

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Muc11A	NP_001285150.1	PRK07764	<366..816	CDD:236090	165/508 (32%)
		PRK07764	<696..1109	CDD:236090	143/425 (34%)
		CBM_14	1495..1547	CDD:279884	11/53 (21%)
COL1A1	NP_000079.2	VWC	40..95	CDD:278520	20/143 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	98..1214		397/1332 (30%)
		Nonhelical region (N-terminal)	162..178		3/15 (20%)
		Triple-helical region	179..1192		366/1212 (30%)
		Collagen	239..295	CDD:396114	16/60 (27%)
		Collagen	275..324	CDD:396114	15/53 (28%)
		PRK07764	<449..640	CDD:236090	66/208 (32%)
		Collagen	500..556	CDD:396114	20/61 (33%)
		Collagen	686..741	CDD:396114	23/65 (35%)
		Collagen	719..766	CDD:396114	18/55 (33%)
		Cell attachment site. /evidence=ECO:0000255	745..747		0/1 (0%)
		PRK12678	908..>1111	CDD:237171	83/271 (31%)
		Cell attachment site. /evidence=ECO:0000255	1093..1095		0/1 (0%)
		Nonhelical region (C-terminal)	1193..1218		4/24 (17%)
		COLFI	1227..1463	CDD:396131	30/165 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000