DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Uch-L5R and bap1

DIOPT Version :9

Sequence 1:	NP_572781.1	Gene:	Uch-L5R / 32173	FlyBaseID:	FBgn0030370	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	NP_001157309.1	Gene:	bap1 / 558885	ZFINID:	ZDB-GENE-050208-492	Length:	755	Species:	Danio rerio

Alignment Length:	330	Identity:	110/330 - (33%)
Similarity:	175/330 - (53%)	Gaps:	64/330 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 WCLIESDPGVFTEMISGFGCTGAEVEEIWSIKADAFRHLEPIHGLIFLFKWLDDKPAGR------ 83
            |..:|||||:||.::..||..|.:||||:.:::   :...|::|.||||||::::.:.|
Zfish     5 WLELESDPGLFTLLVEDFGVKGVQVEEIYDLQS---KCQSPVYGFIFLFKWIEERRSRRKVSTLV 66

  Fly    84 ----VVTDR--SDIFFARQVIPNACATQALLCLLLNLQHEDIDLGQTLTDLRNLCQDLDPECRGH 142
                |:.|.  :|:|||.|:|||:|||.|||.:|||.  ..::||.||:.::...:..:||.:|:
Zfish    67 DETSVIDDDIVNDMFFAHQLIPNSCATHALLSVLLNC--SGVELGMTLSRMKAFTKGFNPESKGY 129

  Fly   143 RLANEEKIRKVHNSFARPELFVVEESTDFIED----DCYHFVGFMPIKGKLFELDGMHEGPIELA 203
            .:.|..::.|.|||.||||...:.|..:.|..    :.:|||.::|||.:||||||:...||:..
Zfish   130 AIGNAPELAKAHNSHARPEPRHLPEKQNGISAVRTMEAFHFVSYVPIKDRLFELDGLKAYPIDHG 194

  Fly   204 DIDQQQNWLDVVRPIIEARMERYSVGE----IHFNLMALVSDRQRCYERKIQMLVNLPSQLSHAD 264
            ...:.:.|.|..|.:|..|:...:.||    |.|||||:|.||:..||.|:.:|        ..:
Zfish   195 PWGEDEEWTDKARRVIMERIGLATAGEPYHDIRFNLMAVVPDRRIKYESKLDIL--------KRN 251

  Fly   265 RQAEIANLRSHVRHEKEKKRRYRKENIRRRHNYLPFIVELLKQLGETGQLMAICDKAKDRSYLCK 329
            ||..:..|    :..:|||                 ::.:.:|  |:||     |:.:..|   .
Zfish   252 RQIILEGL----QQIREKK-----------------VIRMTQQ--ESGQ-----DRKQQDS---S 285

  Fly   330 PSKDT 334
            .|:||
Zfish   286 SSEDT 290

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Uch-L5R	NP_572781.1	Peptidase_C12_UCH37_BAP1	25..238	CDD:187738	87/232 (38%)
bap1	NP_001157309.1	Peptidase_C12_UCH37_BAP1	5..233	CDD:187738	87/232 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	270..354		9/31 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	368..415
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	469..535
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	593..652
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	729..755
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:Q92560	743..748
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2778
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1363547at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820