DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp318a1 and Cyp4f37

DIOPT Version :9

Sequence 1:	NP_727590.1	Gene:	Cyp318a1 / 32172	FlyBaseID:	FBgn0030369	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	XP_038935973.1	Gene:	Cyp4f37 / 691312	RGDID:	1585102	Length:	526	Species:	Rattus norvegicus

Alignment Length:	535	Identity:	137/535 - (25%)
Similarity:	229/535 - (42%)	Gaps:	91/535 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 HLNIALWACGALLAVLLAWQQ---RKCWRL---------IWQLNGWRGVIQQPVLWLLLCINLHP 54
            || :.|.|...:||.:|||..   ..|.||         .|.| |..||||.         |...
  Rat    20 HL-LLLGAASWILARILAWTYSFCENCSRLRCFPQSPKRNWFL-GHLGVIQS---------NEEG 73

  Fly    55 NSILEKVSQ-YR-VHFQRPLAVLVGTRVLLYIDDPAGMECVLNAPECL---DKTFLQ-------D 107
            ..::.::.| :| ||    |..|.....:|.:.|||.:..:|.||..:   |.|||.       |
  Rat    74 MQLVTEMGQTFRDVH----LIWLGPVSPVLRLVDPAFVAPLLQAPALVAPKDPTFLHFLKPWLGD 134

  Fly   108 GFFVRRGLLHARGQKWKLRRKQLNPAFSHNIVASFFDVFNSVGNQMVEQFQTQTNLHGQAVKFTA 172
            |.|:      :.|.||...|:.|.|||..:|:..:...||...|.|..::: ...|.|.| :...
  Rat   135 GLFL------SSGDKWSRHRRLLTPAFHFDILKPYVKTFNQSVNIMHAKWK-HLCLEGSA-RLEM 191

  Fly   173 AEDLLSRAVLEVSCLTIMGTPTNFTQLDDAHIAHSYKRLLEISAV---RVVKPWLQIRLLHRLLA 234
            .|: :|...|:.....:.|..:|..:....:|:.:    ||:|::   |..|.:|.:..|:...|
  Rat   192 FEN-ISLMTLDSLQKCLFGFDSNCQESPSEYISAT----LELSSLTRKRSYKLFLYLDFLYYRTA 251

  Fly   235 PELYEESKKCAKLLEDFVGGIVRTKHRNWRLRDAVGGEKSGEDASNGWQRRIFIEQIFQLAAN-- 297
            ..  :..:|...|:..|...::|.:.   ||..:.|.::..|..:....:.:....:..||.:
  Rat   252 DG--QRFRKACDLVHSFTDAVIRERR---RLLSSQGVDEFLESKTKSKSKTLDFIDVLLLAKDEH 311

  Fly   298 -GEMTLEEIMDEAQSMVLVSFETVSNSIMLALLCLATNKGDCQRRLLAEIRALVPD--VGQVGLE 359
             .|::.|:|..||.:.:....:|.::::...|..||::. :.|.|...|:..|:.|  ..::..:
  Rat   312 GKELSDEDIRAEADTFMFGGHDTTASALSWILYNLASHP-EYQERCRQEVWELLRDREPEEIEWD 375

  Fly   360 QLQQLRYLDAFVSESLRLLATVPMNLRHVSRDFRLA-GRQHETIVPQNSIVVLDTFNMQRDERWW 423
            .|.||.:|...:.|||||.......||..::|..|. ||    ::|:.:|.|:..|.:..:...|
  Rat   376 DLAQLPFLTMCIKESLRLHPPAVDLLRRCTQDIVLPDGR----VIPKGNICVISIFGIHHNPSVW 436

  Fly   424 GANARQFDPQRFLDQEEEQLSKGHNDSGSGEKRRQRDRRHSYSFLPFSNGLRSCIGRRYGLFIMK 488
             .:...:||.|| |.|                  .|.:|...||:|||.|.|:|||:.:.:..:|
  Rat   437 -PDPEVYDPFRF-DPE------------------NRQKRSPLSFIPFSAGPRNCIGQTFAMNEVK 481

  Fly   489 VFLVKLITNFDFQSD 503
            |.:...:..|.|..|
  Rat   482 VAVGLTLLRFRFLPD 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp318a1	NP_727590.1	p450	42..503	CDD:299894	117/481 (24%)
Cyp4f37	XP_038935973.1	CYP4F	74..517	CDD:410772	117/470 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010