DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp318a1 and CYP4F12

DIOPT Version :9

Sequence 1:	NP_727590.1	Gene:	Cyp318a1 / 32172	FlyBaseID:	FBgn0030369	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	NP_076433.3	Gene:	CYP4F12 / 66002	HGNCID:	18857	Length:	524	Species:	Homo sapiens

Alignment Length:	564	Identity:	135/564 - (23%)
Similarity:	230/564 - (40%)	Gaps:	111/564 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LNIALWACGALLAVLLAWQ---QRKCWRLIWQLNGWRGVIQQPV----LWLLLCINLHPNSILEK 60
            |.:..|    |||.:|||.   ...|.||        ....||.    .|..|.:.......|:.
Human    24 LVVGSW----LLARILAWTYAFYNNCRRL--------QCFPQPPKRNWFWGHLGLITPTEEGLKN 76

  Fly    61 VSQYRVHFQRPLAVLVGTRV-LLYIDDPAGMECVLNAPECLDKTFLQDGFFVR-------RGLLH 117
            .:|....:.:...|.:|..: .:.:..|..:..:.||...:..   :|..|:|       .|:|.
Human    77 STQMSATYSQGFTVWLGPIIPFIVLCHPDTIRSITNASAAIAP---KDNLFIRFLKPWLGEGILL 138

  Fly   118 ARGQKWKLRRKQLNPAFSHNIVASFFDVFNSVGNQMVEQFQTQTNLHGQAVKFTAAEDLLSRAVL 182
            :.|.||...|:.|.|||..||:.|:..:||...|.|::::|           ..|:|......:.
Human   139 SGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQ-----------HLASEGSSRLDMF 192

  Fly   183 E-VSCLTIMGTPTNFTQLDDAHIAHSYKR-------LLEISAVRVVKPWLQIRLLHRLLAPELYE 239
            | :|.:|:..........|    :|..:|       :||:||  :|:...|..|.|......|..
Human   193 EHISLMTLDSLQKCIFSFD----SHCQERPSEYIATILELSA--LVEKRSQHILQHMDFLYYLSH 251

  Fly   240 ESK---KCAKLLEDFVGGIVRTKHRNWRLRDAVGGEKSGEDASNGWQRRIFIEQIFQLAANGE-- 299
            :.:   :..:|:.||...::|.:.|....:   |.:...:|.:.. :...||:.:  |.:..|
Human   252 DGRRFHRACRLVHDFTDAVIRERRRTLPTQ---GIDDFFKDKAKS-KTLDFIDVL--LLSKDEDG 310

  Fly   300 --MTLEEIMDEAQSMVLVSFETVSNSIMLALLCLATNKGDCQRRLLAEIRALVP--DVGQVGLEQ 360
              ::.|:|..||.:.:....:|.::.:...|..||.:. :.|.|...|::.|:.  |..::..:.
Human   311 KALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHP-EYQERCRQEVQELLKDRDPKEIEWDD 374

  Fly   361 LQQLRYLDAFVSESLRLLATVPMNLRHVSRDFRLA-GRQHETIVPQNSIVVLDTFNMQRDERWWG 424
            |.||.:|...|.|||||....|...|..::|..|. ||    ::|:....::|...:..:...|
Human   375 LAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGR----VIPKGITCLIDIIGVHHNPTVW- 434

  Fly   425 ANARQFDPQRFLDQEEEQLSKGHNDSGSGEKRRQRDRRHSYSFLPFSNGLRSCIGRRYGLFIMKV 489
            .:...:||.|| |.|.   |||               |...:|:|||.|.|:|||:.:.:..|||
Human   435 PDPEVYDPFRF-DPEN---SKG---------------RSPLAFIPFSAGPRNCIGQAFAMAEMKV 480

  Fly   490 FLVKLITNFDFQSDF-----ELEKLQFVE----------NISLK 518
            .|..::.:|.|..|.     :||.:...|          |:||:
Human   481 VLALMLLHFRFLPDHTEPRRKLELIMRAEGGLWLRVEPLNVSLQ 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp318a1	NP_727590.1	p450	42..503	CDD:299894	116/490 (24%)
CYP4F12	NP_076433.3	p450	52..506	CDD:306555	120/504 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820