DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp318a1 and Cyp4f14

DIOPT Version :9

Sequence 1:	NP_727590.1	Gene:	Cyp318a1 / 32172	FlyBaseID:	FBgn0030369	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	NP_001191262.1	Gene:	Cyp4f14 / 64385	MGIID:	1927669	Length:	524	Species:	Mus musculus

Alignment Length:	536	Identity:	127/536 - (23%)
Similarity:	217/536 - (40%)	Gaps:	127/536 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 WRGVIQQPVLWLLLCINLHPNSILEKVSQYR----VH-FQRP----------------------L 72
            |:.::.....|:|..|      :::..:.||    :| |.:|                      |
Mouse    19 WKTLLLLGASWILARI------LIQIYAAYRNYRHLHGFPQPPKRNWLMGHVGMVTPTEQGLKEL 77

  Fly    73 AVLVGT---RVLLYIDD--PAGMEC-------VLNAPECLDKTFLQDGFF-------VRRGLLHA 118
            ..||||   ..|::|..  |....|       :|||...:   .|:|..|       :..|||.:
Mouse    78 TRLVGTYPQGFLMWIGPMVPVITLCHSDIVRSILNASAAV---ALKDVIFYSILKPWLGDGLLVS 139

  Fly   119 RGQKWKLRRKQLNPAFSHNIVASFFDVFNSVGNQMVEQFQTQTNLHGQAVKFTAAEDLLSRAVLE 183
            .|.||...|:.|.|||..||:..:..:||...|.|..::|...:      ..:|..|:..    .
Mouse   140 AGDKWSRHRRMLTPAFHFNILKPYVKIFNDSTNIMHAKWQRLIS------DGSARLDMFE----H 194

  Fly   184 VSCLT-------IMGTPTNFTQLDDAHIAHSYKRLLEISAV---RVVKPWLQIRLLHRLLAPELY 238
            ||.:|       :....:|..:....:||    .:||:||:   |..:|.:.:.||:. |.|:..
Mouse   195 VSLMTLDSLQKCVFSFDSNCQEKSSEYIA----AILELSALVAKRHQQPLMFMDLLYN-LTPDGM 254

  Fly   239 EESKKCAKLLEDFVGGIVRTKHRNWRLRDAVGGEKSGED---ASNGWQRRIFIEQIFQLAAN--- 297
            ...|.| .::.:|...::|.:||.  |.|      .|.|   .|....:.:....:..|:.:
Mouse   255 RFRKAC-NVVHEFTDAVIRERHRT--LPD------QGLDDFLKSKAKSKTLDFIDVLLLSKDEDG 310

  Fly   298 GEMTLEEIMDEAQSMVLVSFETVSNSIMLALLCLATNKGDCQRRLLAEIRALV----PDVGQVGL 358
            .|::.|:|..||.:.:....:|.::.:...|..||.:. :.|.|...|::.|:    |:  ::..
Mouse   311 KELSDEDIRAEADTFMFEGHDTTASGLSWILYNLARHP-EYQERCRQEVQELLRGREPE--EIEW 372

  Fly   359 EQLQQLRYLDAFVSESLRLLATVPMNLRHVSRDFRLA-GRQHETIVPQNSIVVLDTFNMQRDERW 422
            :.|.||.:|...:.|||||...|.:..|..::|..|. ||    .:|:..|.::..|.:..:...
Mouse   373 DDLAQLPFLTMCIKESLRLHPPVTVISRCCTQDILLPDGR----TIPKGIICLISIFGIHHNPSV 433

  Fly   423 WGANARQFDPQRFLDQEEEQLSKGHNDSGSGEKRRQRDRRHSYSFLPFSNGLRSCIGRRYGLFIM 487
            | .:...:||.||   :.|.:    .||.            ..:|:|||.|.|:|||:.:.:..|
Mouse   434 W-PDPEVYDPFRF---DPENI----KDSS------------PLAFIPFSAGPRNCIGQTFAMSEM 478

  Fly   488 KVFLVKLITNFDFQSD 503
            ||.|...:..|....|
Mouse   479 KVALALTLLRFRLLPD 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp318a1	NP_727590.1	p450	42..503	CDD:299894	125/527 (24%)
Cyp4f14	NP_001191262.1	p450	52..511	CDD:365848	119/497 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820