DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp318a1 and Cyp4f1

DIOPT Version :9

Sequence 1:	NP_727590.1	Gene:	Cyp318a1 / 32172	FlyBaseID:	FBgn0030369	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	NP_062569.2	Gene:	Cyp4f1 / 56266	RGDID:	70926	Length:	524	Species:	Rattus norvegicus

Alignment Length:	535	Identity:	124/535 - (23%)
Similarity:	208/535 - (38%)	Gaps:	104/535 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ALWACGALLAVLLAWQQRKCWRLIWQLNGWRGVIQQPVL-WLLLCINLHP------NSILEKVSQ 63
            |.|....:|..:.| ..|...||       ||..|.|.. ||:..:.:..      ..:...|..
  Rat    27 ASWILAQILTQIYA-AYRNFRRL-------RGFPQPPKRNWLMGHVGMVTPTEQGLKELTRLVGT 83

  Fly    64 YRVHFQRPLAVLVGTRVLLYIDDPAGMECVLNAPECLDKTFLQDGFF-------VRRGLLHARGQ 121
            |...|...:..:|....|.:.|.   :..:|||...:   .|:|..|       :..|||.:.|.
  Rat    84 YPQGFLMWIGPMVPVITLCHSDI---VRSILNASAAV---ALKDVIFYTILKPWLGDGLLVSAGD 142

  Fly   122 KWKLRRKQLNPAFSHNIVASFFDVFNSVGN-------QMVEQFQTQTNLHGQAVKFTAAEDLLSR 179
            ||...|:.|.|||..||:..:..:||...|       :::.:..::.::.......|.  |.|.:
  Rat   143 KWSRHRRMLTPAFHFNILKPYVKIFNDSTNIMHAKWKRLISEGSSRLDMFEHVSLMTL--DSLQK 205

  Fly   180 AVLEVSCLTIMGTPTNFTQLDDAHIAHSYKRLLEISAV---RVVKPWLQIRLLHRLLAPELYEES 241
            .|....        :|..:....:||    .:||:||:   |..:|.|.:.||:. |.|:.....
  Rat   206 CVFSFD--------SNCQEKSSEYIA----AILELSALVAKRHQQPLLFMDLLYN-LTPDGMRFH 257

  Fly   242 KKCAKLLEDFVGGIVRTKHRNWRLRDAVGGEKSGED---ASNGWQRRIFIEQIFQLAAN---GEM 300
            |.| .|:.:|...::|.:.|.  |.|      .|.|   .|....:.:....:..|..:   .|:
  Rat   258 KAC-NLVHEFTDAVIRERRRT--LPD------QGLDEFLKSKAKSKTLDFIDVLLLTKDEDGKEL 313

  Fly   301 TLEEIMDEAQSMVLVSFETVSNSIMLALLCLATNKGDCQRRLLAEIRALV--PDVGQVGLEQLQQ 363
            :.|:|..||.:.:....:|.::.:...|..||.:. :.|.|...|::.|:  .|..::..:.|.|
  Rat   314 SDEDIRAEADTFMFEGHDTTASGLSWILYNLAKHP-EYQERCRQEVQELLRDRDPEEIEWDDLAQ 377

  Fly   364 LRYLDAFVSESLRLLATVPMNLRHVSRDFRLA-GRQHETIVPQNSIVVLDTFNMQRDERWWG--- 424
            |.:|...:.|||||...|.:..|..::|..|. ||    .:|:..|.::..|.:..:...|.
  Rat   378 LPFLTMCIKESLRLHPPVTVISRCCTQDILLPDGR----TIPKGIICLISIFGIHHNPSVWPDPE 438

  Fly   425 -ANARQFDPQRFLDQEEEQLSKGHNDSGSGEKRRQRDRRHSYSFLPFSNGLRSCIGRRYGLFIMK 488
             .|..:|||:...|..                        ..:|:|||.|.|:|||:.:.:..||
  Rat   439 VYNPFRFDPENIKDSS------------------------PLAFIPFSAGPRNCIGQTFAMSEMK 479

  Fly   489 VFLVKLITNFDFQSD 503
            |.|...:..|....|
  Rat   480 VALALTLLRFRLLPD 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp318a1	NP_727590.1	p450	42..503	CDD:299894	113/497 (23%)
Cyp4f1	NP_062569.2	CYP4F	74..515	CDD:410772	111/480 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820