DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp318a1 and Cyp4f40

DIOPT Version :9

Sequence 1:	NP_727590.1	Gene:	Cyp318a1 / 32172	FlyBaseID:	FBgn0030369	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	XP_038935701.1	Gene:	Cyp4f40 / 503122	RGDID:	1559596	Length:	530	Species:	Rattus norvegicus

Alignment Length:	581	Identity:	137/581 - (23%)
Similarity:	232/581 - (39%)	Gaps:	109/581 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 HLNIALWACGALLA--------VLLAWQQRKCWRLIWQL----NGWRGVIQQPV-LWLLLCINLH 53
            ||:::....|.:.|        |.::|...:|...|:.|    ....|..|.|. .|....:.:.
  Rat     3 HLDLSWLGLGPMSASPWLLLSLVGVSWFLTRCLTQIYTLYAKCQRLCGFPQPPKRSWFWGHLGMS 67

  Fly    54 P------NSILEKVSQYRVHFQRPLAVLVGTRVLLYIDDPAGMECVLNAPECLDKTFLQDGFF-- 110
            |      ..:.|.|:.|...|...|..:|   .|:.:..|..:..||:|...:..   :||.|
  Rat    68 PPTEEGMKQMTELVATYPQGFMTWLGPIV---PLITLCHPDIIRSVLSASAAVAP---KDGIFYS 126

  Fly   111 -----VRRGLLHARGQKWKLRRKQLNPAFSHNIVASFFDVFNSVGNQMVEQFQTQTNLHGQAVKF 170
                 :..|||.:...||...|..|.|||..||:..:..:||...|.|          |.:.::.
  Rat   127 FLKPWLGDGLLVSASDKWSRHRSMLTPAFHFNILKPYVKIFNDSTNIM----------HAKWLRL 181

  Fly   171 ----TAAEDL---LSRAVLEVSCLTIMGTPTNFTQLDDAHIAHSYKRLLEISAVRVVKPWLQIRL 228
                :|..|:   :|...|:.....:....:|..:....:||    .:||:||: |||...|: |
  Rat   182 ASGGSAHLDMFENISLMTLDTLQKCVFSFNSNCQEKPSEYIA----AILELSAL-VVKRNEQL-L 240

  Fly   229 LHRLLAPELYEESK---KCAKLLEDFVGGIVRTKHRNWRLRDAVGGEKSGEDASNGWQRRIFIEQ 290
            ||..|...|..:.:   |...|:.||...:::.:.|..       .:..|:|......:...::.
  Rat   241 LHMDLLYRLTPDGRRFYKACHLVHDFTYAVIQERRRTL-------PKHGGDDVIKAKAKSKTLDF 298

  Fly   291 IFQLAAN-----GEMTLEEIMDEAQSMVLVSFETVSNSIMLALLCLATNKGDCQRRLLAEIRALV 350
            |..|..:     .|::.|:|..||.:.:....:|.::.:...|..||.:. :.|.|...|::.|:
  Rat   299 IDVLLLSKDEDGKELSDEDIRAEADTFMFEGHDTTASGLSWILYNLAKHP-EYQERCRQEVQELL 362

  Fly   351 PD---------VGQVGLEQLQQLRYLDAFVSESLRLLATVPMNLRHVSRDFRLA-GRQHETIVPQ 405
            .|         .|.:..:.|.||.:|...:.|||||...|.|..|..::|..|. ||    ::|:
  Rat   363 RDRDSEEIECSCGVLLRDDLAQLPFLTMCIKESLRLHPPVTMVSRCCTQDISLPDGR----VIPK 423

  Fly   406 NSIVVLDTFNMQRDERWWGANARQFDPQRFLDQEEEQLSKGHNDSGSGEKRRQRDRRHSYSFLPF 470
            ..|.:::.|....:...| .:...:||.|| |.|..|                  .|...:|:||
  Rat   424 GIICIINIFATHHNPTVW-QDPEVYDPFRF-DPENIQ------------------ARSPLAFIPF 468

  Fly   471 SNGLRSCIGRRYGLFIMKVFLVKLITNFDFQSDFELEKLQFVENISLKFKNADDILLTIQP 531
            |.|.|:|||:.:.:..|||.:...:..|....| :.|..:..|   |..:..|.:.|.::|
  Rat   469 SAGPRNCIGQTFAMNEMKVAVALTLLRFRVLPD-DKEPRRKPE---LILRAEDGLWLRVEP 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp318a1	NP_727590.1	p450	42..503	CDD:299894	119/499 (24%)
Cyp4f40	XP_038935701.1	CYP4F	74..522	CDD:410772	121/505 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820