DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp318a1 and Cyp12a4

DIOPT Version :9

Sequence 1:	NP_727590.1	Gene:	Cyp318a1 / 32172	FlyBaseID:	FBgn0030369	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	NP_650783.2	Gene:	Cyp12a4 / 42294	FlyBaseID:	FBgn0038681	Length:	536	Species:	Drosophila melanogaster

Alignment Length:	571	Identity:	128/571 - (22%)
Similarity:	211/571 - (36%)	Gaps:	145/571 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 WQQRKCWRLIWQLNGWRGVIQQPVLWLLLCI------NLHPNSILEKVSQ-YRVHFQRPLAVLVG 77
            |.|.|.:..|.:||.|       .|.:.:.:      |:....:.|.:.| |...|..|  .::|
  Fly    41 WLQAKPFEQIPRLNMW-------ALSMKMSMPGGKYKNMELMEMFEAMRQDYGDIFFMP--GIMG 96

  Fly    78 TRVLLYIDDPAGMECVL-------NAP---------ECLDKTFLQDGFFVRRGLLHARGQKWKLR 126
            ....|...:|...|.|.       |.|         |...|.|.|...    |::..:|:.|...
  Fly    97 NPPFLSTHNPQDFEVVFRNEGVWPNRPGNYTLLYHREEYRKDFYQGVM----GVIPTQGKPWGDF 157

  Fly   127 RKQLNPAFSH-NIVASFFDVFNSVGNQMVEQFQTQTNLHGQAVKFTAAEDLLSRAVLEVSCLTIM 190
            |..:||.... ..|..::...:.|..:.|::                        :||:.....:
  Fly   158 RTVVNPVLMQPKNVRLYYKKMSQVNQEFVQR------------------------ILELRDPDTL 198

  Fly   191 GTPTNFTQLDDAHIAHSYKRLLEISAVRVVKPWLQIRLLHRLLAPELYEESKKCAKLLEDF--VG 253
            ..|.:|....:.....|      :|.|.:.|   |:.||..   .....|:.|....|::|  |.
  Fly   199 EAPDDFIDTINRWTLES------VSVVALDK---QLGLLKN---SNKESEALKLFHYLDEFFIVS 251

  Fly   254 GIVRTKHRNW---------RLRDAVGG-------------EKSGEDASNGWQRRIFIEQIFQLAA 296
            ..:..|...|         ||..|:.|             |:..::|..|..|          ..
  Fly   252 IDLEMKPSPWRYIKTPKLKRLMRALDGIQEVTLAYVDEAIERLDKEAKEGVVR----------PE 306

  Fly   297 NGEMTLEEIMD--------EAQSMVLVSFETVSNSIMLALLCLATNKGDCQRRLLAEIRALVPDV 353
            |.:..||:::.        .|..|::...:|.|::....|||||.|. :.|.||..|:..::|:.
  Fly   307 NEQSVLEKLLKVDRKVATVMAMDMLMAGVDTTSSTFTALLLCLAKNP-EKQARLREEVMKVLPNK 370

  Fly   354 GQVGLE-QLQQLRYLDAFVSESLRLLATVPMNLRHVSRD-----FRLAGRQHETIVPQNSIVVLD 412
            .....| .::.:.||.|.:.||.||...:..|.|.::||     :|:....:..|||.|::.
  Fly   371 NSEFTEASMKNVPYLRACIKESQRLHPLIVGNARVLARDAVLSGYRVPAGTYVNIVPLNALT--- 432

  Fly   413 TFNMQRDERWWGANARQFDPQRFLDQEEEQLSKGHNDSGSGEKRRQRDRRHSYSFLPFSNGLRSC 477
                 |||  :...|.:|.|:|:|        :...||.|.....:....:.:.||||..|.|.|
  Fly   433 -----RDE--YFPQASEFLPERWL--------RSPKDSESKCPANELKSTNPFVFLPFGFGPRMC 482

  Fly   478 IGRRYGLFIMKVFLVKLITNFDFQSDFELEK-----LQFVENISLKFKNAD 523
            :|:|.....:::...:||.||:.:.::..|.     |..:.||.||||..|
  Fly   483 VGKRIVEMELELGTARLIRNFNVEFNYPTENAFRSALINLPNIPLKFKFID 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp318a1	NP_727590.1	p450	42..503	CDD:299894	112/522 (21%)
Cyp12a4	NP_650783.2	p450	72..531	CDD:299894	117/529 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45442730
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24305
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030