DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp318a1 and Cyp313a4

DIOPT Version :9

Sequence 1:	NP_727590.1	Gene:	Cyp318a1 / 32172	FlyBaseID:	FBgn0030369	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	NP_650224.3	Gene:	Cyp313a4 / 41563	FlyBaseID:	FBgn0038076	Length:	494	Species:	Drosophila melanogaster

Alignment Length:	549	Identity:	150/549 - (27%)
Similarity:	256/549 - (46%)	Gaps:	76/549 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LNIALWACGA--LLAVLLAWQQRKCWRLIWQLNGWRGVIQQPVL----WLLLCINLHPNSILEKV 61
            |...|| ||.  ||.:...|.:|:.:.|..::.|..|   .|:|    ||     :....||...
  Fly     2 LTWTLW-CGLLFLLWIYFLWSRRRFYLLTLKIPGPLG---YPILGMAHWL-----MRREDILNAF 57

  Fly    62 SQYRVHFQRPLAVLVGTRVLLYIDDPAGMECVLNAPECLDKTFL----QDGFFVRRGLLHARGQK 122
            ..:.......:...:|....:.:.||..::.:..:|.|::|..:    .||..|  ||...:..:
  Fly    58 GCFLDKHGPTIFSWLGPIPFMIVSDPQVVQDIFTSPHCVNKGIIYKAVDDGAGV--GLFSLKDPR 120

  Fly   123 WKLRRKQLNPAFSHNIVASFFDVFNSVGNQMVEQFQTQTNLHGQAVKFTAAED---LLSRAVLEV 184
            |.:.||.|||||.|.::.||..:||.....:::|.        :.::....:|   ||....|.:
  Fly   121 WSIHRKLLNPAFGHKVLLSFLPIFNRETALLLDQL--------EPLQDDGEKDLIPLLQSFTLGI 177

  Fly   185 SCLTIMGTPTNFTQLDDAHIAHS----YKRLLEISAVRVVKPWLQIRLLHRLLAPELYEESKKCA 245
            :..|.||:.   .:.:::..::|    |:.:||........|||..|...:|...|.:....|..
  Fly   178 ATQTTMGSD---VKDEESFRSNSLLGRYQCILETMTDMCFSPWLNSRFCRQLAGKESHYYQAKTE 239

  Fly   246 KLLEDFVGGIVRTKHRNWRLRDAVGGEKSGEDASNGWQRRIFIEQIFQLAANGEMTLEEIMDEAQ 310
              :..|:..|:..|    ...|.:|...|.:  ||  .:.:|:..:..|...|..||:.:.||:.
  Fly   240 --IRQFIRKIIERK----LAEDEMGALPSIQ--SN--DKNLFLNLVTDLMRRGVFTLKNVEDESN 294

  Fly   311 SMVLVSFETVSNSIMLALLCLATNKGDCQRRLLAEIRALVPDVG--QVGLEQLQQLRYLDAFVSE 373
            .:|..:|||.:|::...|:.||... :.|.|...||:.:.|:.|  .|.....||:.|||..::|
  Fly   295 IIVFGAFETTANAVYYTLMLLAMFP-EYQERAFEEIKTIFPNTGDFDVSYADTQQMVYLDLILNE 358

  Fly   374 SLRLLATVPMNLRHVSRDFRLAGRQHETIVPQNSIVVLDTFNMQRDERWWGANARQFDPQRFLDQ 438
            |:|::..||:..|..|:|.:|:   :..:||:...:.:|.::|.|.::.||.:|..|:|..||.
  Fly   359 SMRVIPPVPVVSRQTSQDLKLS---NGIVVPKGVQIAIDIYHMHRSKKIWGPDAETFNPDHFLP- 419

  Fly   439 EEEQLSKGHNDSGSGEKRRQRDRRHSYSFLPFSNGLRSCIGRRYGLFIMKVFLVKLITNFDFQSD 503
                    ||...          :|.|:::||:.|:|:|||.||.|...||.|.||:.|:.|::.
  Fly   420 --------HNIQD----------KHPYAYIPFTKGIRNCIGWRYALISAKVTLAKLLRNYRFKTS 466

  Fly   504 FELEKLQFVENISLKFKNADDILLTIQPK 532
            |..|.|.|||:|::|.|:..  ||.:|.:
  Fly   467 FPFENLYFVEDITMKLKSVP--LLELQKR 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp318a1	NP_727590.1	p450	42..503	CDD:299894	126/477 (26%)
Cyp313a4	NP_650224.3	p450	33..465	CDD:299894	128/485 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450083
Domainoid	1	1.000	82	1.000	Domainoid score	I1949
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	82	1.000	Inparanoid score	I1605
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0008559
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24305
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.890