DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp318a1 and Cyp313a3

DIOPT Version :9

Sequence 1:	NP_727590.1	Gene:	Cyp318a1 / 32172	FlyBaseID:	FBgn0030369	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	NP_650170.2	Gene:	Cyp313a3 / 41488	FlyBaseID:	FBgn0038007	Length:	492	Species:	Drosophila melanogaster

Alignment Length:	543	Identity:	146/543 - (26%)
Similarity:	244/543 - (44%)	Gaps:	101/543 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LWACGALLAVLLAWQQRKCWRLIWQLNGWRGVIQQPVLWLLLCINLHPNSILEKVSQYRVHFQRP 71
            |.|.|....:...|.:|:.:.:.:::.|..|:   |:|.:..              :|.:.::|.
  Fly     7 LLAVGVCFWIYFLWSRRRLYMMHFKIPGPMGL---PILGIAF--------------EYLITYKRK 54

  Fly    72 LAV------LVGTRVLLYID--------DPAGMECVLNAPECLDKTFLQDGFFVR-------RGL 115
            :::      :.|:..|:::.        ||...|.:..:||||:::    ..|.:       .||
  Fly    55 MSIRTKYMDIYGSTCLVWVGPTPFVITRDPKIAEEIFLSPECLNRS----SIFSKPVNSCTGDGL 115

  Fly   116 LHARGQKWKLRRKQLNPAFSHNIVASFFDVFNSVGNQMVEQFQTQTNLHGQAVKFTAAEDLLSRA 180
            |.....||..|||.|||||..|::.||..:|||....:|....   :|.||..|  ...|.:.|.
  Fly   116 LSLEASKWVDRRKNLNPAFKQNVLLSFLPIFNSEAKTLVAFLD---SLVGQGEK--KVRDDIVRW 175

  Fly   181 VLEVSCLTIMGTPTNFTQLDDA-----HIAHSYKRLLEISAVRVVKPWLQIRLLHRLLAPELYEE 240
            ...::..|.:||...    .||     .:..||:..::|..:.|:.|:...::...|..   :|.
  Fly   176 SFRIATQTTVGTDVK----KDASFKNDSVLKSYETFMKIIVMNVLLPFTHNKIFSTLGG---FET 233

  Fly   241 SKKCAKL-LEDFVGGIVRTKHRNWRLRDAVGGEKSGEDASNGWQRRI--FIEQIFQLAANGEMTL 302
            .|..||. :...:|.||              .:|......:|.|..|  .|.:..:|..||||:.
  Fly   234 QKALAKSNVNKMIGTIV--------------DKKLMTKPESGSQPEITSVINKAIELHRNGEMSR 284

  Fly   303 EEIMDEAQSMVLVSFETVSNSIMLALLCLATNKGDCQRRLLAEIRALVPDVG--QVGLEQLQQLR 365
            ||:..|..|.|:.:|||..:::..||:.||... :.|..:..|::.|.|..|  :|..:.||::.
  Fly   285 EEVQSECCSFVVAAFETTGDTVYHALILLAMFP-EHQDTVYQELKELFPVAGDFEVTYDDLQRMV 348

  Fly   366 YLDAFVSESLRLLATVPMNLRHVSRDFRLAGRQHETIVPQNSIVVLDTFNMQRDERWWGANARQF 430
            :|:..|:|:|||:.:||...|...|||||:.   ..::|:...:.:|.|...|:...||.:...|
  Fly   349 FLERVVNETLRLIPSVPFTPRETIRDFRLSS---GVVIPKGVGIGIDIFATHRNRDHWGTDPSSF 410

  Fly   431 DPQRFLDQEEEQLSKGHNDSGSGEKRRQRDRRHSYSFLPFSNGLRSCIGRRYGLFIMKVFLVKLI 495
            :|..||..                  ..|| ||.|:::|||.|.|:|||.:|||...|:.|.|::
  Fly   411 NPDHFLPD------------------NVRD-RHPYAYIPFSKGRRNCIGWKYGLMSSKLALSKIL 456

  Fly   496 TNFDFQSDFELEKLQFVENISLK 518
            .|....:.|..|.|:||:||.::
  Fly   457 RNCKVSTSFRYEDLEFVDNIGME 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp318a1	NP_727590.1	p450	42..503	CDD:299894	132/491 (27%)
Cyp313a3	NP_650170.2	p450	33..463	CDD:299894	134/499 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450085
Domainoid	1	1.000	82	1.000	Domainoid score	I1949
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	82	1.000	Inparanoid score	I1605
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0008559
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24305
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.890