Protein Alignment Cyp318a1 and CYP4F3

DIOPT Version :9

• Sequence 1: NP_727590.1
• Gene: Cyp318a1 / 32172
• FlyBaseID: FBgn0030369
• Length: 536
• Species: Drosophila melanogaster
• Sequence 2: NP_000887.2
• Gene: CYP4F3 / 4051
• HGNCID: 2646
• Length: 520
• Species: Homo sapiens
• Alignment Length: 561
• Identity: 130/561 - (23%)
• Similarity: 219/561 - (39%)
• Gaps: 145/561 - (25%)

  Fly     4 NIALWACGA-------------LLAVLLAWQQR---KCWRLIWQLNGWRGVIQQPVL-WLLLCIN 51
            ::.||...|             |||.:|||...   .|.||       |...|.|.. |.|..:.
Human     8 SLGLWPMAASPWLLLLLVGASWLLARILAWTYTFYDNCCRL-------RCFPQPPKRNWFLGHLG 65

  Fly    52 L-HPNSILEKVSQYRVHFQRPLAVLVGT---------RVLLYIDDPAGMECVLNAPECL---DKT 103
            | |.       |:..:.:.:.||...|.         ..::.|..|..::.||.||..:   ||.
Human    66 LIHS-------SEEGLLYTQSLACTFGDMCCWWVGPWHAIVRIFHPTYIKPVLFAPAAIVPKDKV 123

  Fly   104 FLQDGFFVR----RGLLHARGQKWKLRRKQLNPAFSHNIVASFFDVFNSVGNQMVEQFQTQTNLH 164
            |..   |::    .|||.:.|:||...|:.|.|||..||:..:..:||...|.|..::|.
Human   124 FYS---FLKPWLGDGLLLSAGEKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQL----- 180

  Fly   165 GQAVKFTAAEDLLSRAVLEVSCLT-------IMGTPTNFTQLDDAHIAHSYKRLLEISAVRVVKP 222
             .|.:.:|..|:..    .:|.:|       :....::..:....:||    .:||:||: |.|.
Human   181 -LASEGSARLDMFE----HISLMTLDSLQKCVFSFDSHCQEKPSEYIA----AILELSAL-VTKR 235

  Fly   223 WLQIRLLH----RLLAPELYEESKKCAKLLEDFVGGIVRTKHRNWRLRDAVGGEKSGEDASNGWQ 283
            ..|| ||:    ..|.|: .:..::..:|:.||...:::.:.|..              .|.|
Human   236 HQQI-LLYIDFLYYLTPD-GQRFRRACRLVHDFTDAVIQERRRTL--------------PSQG-- 282

  Fly   284 RRIFIEQIFQLAANG------------------EMTLEEIMDEAQSMVLVSFETVSNSIMLALLC 330
                ::...|..|..                  :::.|:|..||.:.:....:|.::.:...|..
Human   283 ----VDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYH 343

  Fly   331 LATNKGDCQRRLLAEIRALVPD--VGQVGLEQLQQLRYLDAFVSESLRLLATVPMNLRHVSRDFR 393
            ||.:. :.|.|...|::.|:.|  ..::..:.|.||.:|...:.|||||...||...|..::|..
Human   344 LAKHP-EYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIV 407

  Fly   394 LA-GRQHETIVPQNSIVVLDTFNMQRDERWWGANARQFDPQRFLDQEEEQLSKGHNDSGSGEKRR 457
            |. ||    ::|:..|.::..|....:...| .:...:||.||..:..::
Human   408 LPDGR----VIPKGIICLISVFGTHHNPAVW-PDPEVYDPFRFDPKNIKE--------------- 452

  Fly   458 QRDRRHSYSFLPFSNGLRSCIGRRYGLFIMKVFLVKLITNF 498
                |...:|:|||.|.|:|||:.:.:..|||.|...:..|
Human   453 ----RSPLAFIPFSAGPRNCIGQAFAMAEMKVVLGLTLLRF 489

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp318a1	NP_727590.1	p450	42..503	CDD:299894	116/507 (23%)
CYP4F3	NP_000887.2	p450	52..515	CDD:365848	117/510 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820