DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp318a1 and Cyp4d8

DIOPT Version :9

Sequence 1:	NP_727590.1	Gene:	Cyp318a1 / 32172	FlyBaseID:	FBgn0030369	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	NP_523961.2	Gene:	Cyp4d8 / 38841	FlyBaseID:	FBgn0015033	Length:	505	Species:	Drosophila melanogaster

Alignment Length:	528	Identity:	123/528 - (23%)
Similarity:	241/528 - (45%)	Gaps:	55/528 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LNIALWACGALLAVLLAWQQRKCWRLIWQLNGWRGVIQQPVLWLL-LCINLHPNSILEKVSQYRV 66
            |.:.|:..|.::.:..|.::||...|       .|.|..|::..: |.:.|:|.:.::...:|.:
  Fly     6 LVVLLFGAGWIIHLGQADRRRKVANL-------PGPICPPLIGAMQLMLRLNPKTFIKVGREYVL 63

  Fly    67 HFQRPLAVLVGTRVLLYIDDPAGMECVLNAPECLDK--TFLQDGFFVRRGLLHARGQKWKLRRKQ 129
            .|.....|.:..|:|:...|....|.:|::.|.|.|  .:...|.::..|||.:.|:.|..|||.
  Fly    64 KFGHLQRVWIFNRLLIMSGDAELNEQLLSSQEHLVKHPVYKVLGQWLGNGLLLSDGKVWHQRRKI 128

  Fly   130 LNPAFSHNIVASFFDVFNSVGNQMVEQFQTQTNLHGQAVKFTAAEDLLSRAVLEVSCLTIMGTPT 194
            :.|.|..:|:..|.:||:...|..|::...:.|  |..  |.....:.: |.|::...|.|||..
  Fly   129 ITPTFHFSILEQFVEVFDQQSNICVQRLAQKAN--GNT--FDVYRSICA-AALDIIAETAMGTKI 188

  Fly   195 NFTQLDDAHIAHSYKRLLEISAVRVVKPWLQIRLLHRLLAPELYEESKKCAKLLEDFVGGIVRTK 259
            .....:....|.:......:.:.|.:..:||:.||..|..|.|.....:..:.:::|...::  :
  Fly   189 YAQANESTPYAEAVNECTALLSWRFMSVYLQVELLFTLTHPHLKWRQTQLIRTMQEFTIKVI--E 251

  Fly   260 HRNWRLRDAVGGEKSGEDASNGWQRRI-FIEQIFQLAANGE-MTLEEIMDEAQSMVLVSFETVSN 322
            .|...|.|.........|...|.:||: .::.:.....:|. :|.:||.:|..:.:....:|.::
  Fly   252 KRRQALEDQQSKLMDTADEDVGSKRRMALLDVLLMSTVDGRPLTNDEIREEVDTFMFEGHDTTTS 316

  Fly   323 SIMLALLCLATNKGDCQRRLLAEI-RALVPDVGQ-VGLEQLQQLRYLDAFVSESLRLLATVPMNL 385
            ::...|..|:.:. :.|.::|.|| :.|..|..: |.:..|.:|:|::..:.||||:...||:..
  Fly   317 ALSFCLHELSRHP-EVQAKMLEEIVQVLGTDRSRPVSIRDLGELKYMECVIKESLRMYPPVPIVG 380

  Fly   386 RHVSRDFRLAGRQH-ETIVPQNSIVVLDTFNMQRDERWWGANARQFDPQRFLDQEEEQLSKGHND 449
            |.:..||:.....| :.::|..|.:::..|.:.|....: .|..:|.|:|             ::
  Fly   381 RKLQTDFKYTHSVHGDGVIPAGSEIIIGIFGVHRQPETF-PNPDEFIPER-------------HE 431

  Fly   450 SGSGEKRRQRDRRHSYSFLPFSNGLRSCIGRRYGLFIMKVFLVKLITNFDFQSDFEL----EKLQ 510
            :||        |...:..:|||.|.|:|||:::....||:.|.|::      .::||    ::::
  Fly   432 NGS--------RVAPFKMIPFSAGPRNCIGQKFAQLEMKMMLAKIV------REYELLPMGQRVE 482

  Fly   511 FVENISLK 518
            .:.||.|:
  Fly   483 CIVNIVLR 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp318a1	NP_727590.1	p450	42..503	CDD:299894	109/468 (23%)
Cyp4d8	NP_523961.2	CYP4	66..497	CDD:410721	108/461 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.920