DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp318a1 and Cyp12b2

DIOPT Version :9

Sequence 1:	NP_727590.1	Gene:	Cyp318a1 / 32172	FlyBaseID:	FBgn0030369	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	NP_611370.2	Gene:	Cyp12b2 / 37163	FlyBaseID:	FBgn0034387	Length:	535	Species:	Drosophila melanogaster

Alignment Length:	563	Identity:	114/563 - (20%)
Similarity:	218/563 - (38%)	Gaps:	130/563 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 WQQRKCWRLIWQLNGWRGVIQQPVLWLLLCINLHPNSILEKVSQYRVHFQRPLAVLVGTRVLLYI 84
            |||.:.:          |.|..|.|..:|...: |...|...:  .:...|.:..:.|....:
  Fly    47 WQQARSF----------GEIPGPSLLRMLSFFM-PGGALRNTN--LIQMNRLMREMYGDIYCI-- 96

  Fly    85 DDPAGMECVLNA-----PECLDKTFLQDGFFVRR----------------------GLLHARGQK 122
               .||....||     |:..:.|:..:|.:..|                      ||...:||:
  Fly    97 ---PGMMGKPNAVFTYNPDDFEMTYRNEGVWPIRIGLESLNYYRKIHRPDVFKGVGGLASDQGQE 158

  Fly   123 WKLRRKQLNPAFSH-NIVASFFDVFNSVGNQMVEQFQTQ---------TNLHGQAVKFTAAEDLL 177
            |...|.::||.... ..|.......:.:..:.:::.:||         |:.|.| :|..|.|
  Fly   159 WADIRNKVNPVLMKVQNVRQNLPQLDQISKEFIDKLETQRNPETHTLTTDFHNQ-LKMWAFE--- 219

  Fly   178 SRAVLEVSCLTIMGTPTNFTQLDDAHIAHSYKRLLEISAVRVVKP--WLQIRLLHRLLAPELYEE 240
              ::..|:..|.||..::....:...:|...:.....|....|:|  |            ..|:.
  Fly   220 --SISFVALNTRMGLLSDNPDPNADRLAKHMRDFFNYSFQFDVQPSIW------------TFYKT 270

  Fly   241 S--KKCAKL---LEDFVGGIVRTKHRNWRLRDAVGGEKSGEDASNGWQRRIFIEQIFQLAANGEM 300
            :  ||..|.   :.|.....:.|..|.:...|            :| :.:..:||:  |..|.::
  Fly   271 AGFKKFLKTYDNITDITSNYIETAMRGFGKND------------DG-KTKCVLEQL--LEHNKKV 320

  Fly   301 TLEEIMDEAQSMVLVSFETVSNSIMLALLCLATNKGDCQRRLLAEIRALVPDVGQVGLEQ-LQQL 364
            .:..:||    |::...:|.|::.:..|..||.|... |.:|..|:..::|.......:| .:.:
  Fly   321 AVTMVMD----MLMAGIDTTSSACLTILYHLARNPSK-QEKLRRELLRILPTTKDSLTDQNTKNM 380

  Fly   365 RYLDAFVSESLRLLATVPMNLRHVSRDFRLAGRQHETIVPQNSIVVLDTFNMQRDERWWGANARQ 429
            .||.|.:.|.||:.:..|.|.|...:|..|:|.|    ||:.:.|::....:..|:::: |.:.:
  Fly   381 PYLRACIKEGLRITSITPGNFRITPKDLVLSGYQ----VPRGTGVLMGVLELSNDDKYF-AQSSE 440

  Fly   430 FDPQRFLDQEEEQLSKGHNDSGSGEKRRQRDRRHSYSFLPFSNGLRSCIGRRYGLFIMKVFLVKL 494
            |.|:|:|..:...      |..:....|   .|:.:.:|||..|.|:|||:|.....::..||:|
  Fly   441 FIPERWLKSDLAP------DIQACPAAR---TRNPFVYLPFGFGPRTCIGKRIAELEIETLLVRL 496

  Fly   495 ITNFDFQSDFELEKLQFVENISLKFKN------ADDILLTIQP 531
            :.::         |:.::....:::::      ..||...::|
  Fly   497 LRSY---------KVSWLPETPIEYESTIILSPCGDIRFKLEP 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp318a1	NP_727590.1	p450	42..503	CDD:299894	105/505 (21%)
Cyp12b2	NP_611370.2	p450	59..511	CDD:299894	106/520 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45442772
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24305
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030