DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp318a1 and Cyp311a1

DIOPT Version :9

Sequence 1:	NP_727590.1	Gene:	Cyp318a1 / 32172	FlyBaseID:	FBgn0030369	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	NP_572780.3	Gene:	Cyp311a1 / 32170	FlyBaseID:	FBgn0030367	Length:	483	Species:	Drosophila melanogaster

Alignment Length:	535	Identity:	118/535 - (22%)
Similarity:	211/535 - (39%)	Gaps:	85/535 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 IALWACGALLAVLLAWQQRKCWRLIWQLNGWRGVIQQPVLWLLLCI-NLHPNSILEKVSQYRVHF 68
            :|||.  .||..|..|...:.|.|:...:...|....|:|.....: .|.|..|....::.|..|
  Fly     1 MALWP--LLLITLTIWILVRKWTLLRLGSSLPGPWAFPLLGNAQMVGKLRPEYIFLVFTELRDRF 63

  Fly    69 QRPLAVLVGTRVLLYIDDPAGMECVLNAPECLDK--TFLQDGFFVRRGLLHARGQKWKLRRKQLN 131
            .....:.:|.::.:::.........|:.| .|.|  ||:|....:..|||.:.|..|..:|:.|.
  Fly    64 GATYRLRLGPQLWVFLHSAEETRQALHDP-TLRKADTFMQLEPLIGNGLLISHGAHWTRQRRLLT 127

  Fly   132 PAFSHNIVASFFDVFNSVGNQMVEQFQTQTNLHGQAVKFTAAEDLLSRAVLEVSCLTIMGTPTNF 196
            |||...::.||.........::|.:      |......|....:.|...:|:....|.||...:.
  Fly   128 PAFQPQLLRSFAPAIGGHVERLVGR------LGATRGAFLEVTEPLFACLLDAIVDTSMGAQLDT 186

  Fly   197 TQLDDAHIAHSYKRLLEISAVRVVKP-----WL------------QIRLLHRLLAPELYEESKKC 244
            ..:|.:.|..::....::...|::.|     |:            |::::|    .::....:|.
  Fly   187 QSVDHSPIIQAFHLSSKLLFKRMINPLLSSDWIFQRTQLWRDLDEQLQVIH----SQMESVIEKR 247

  Fly   245 AKLLEDFVGGIVRTKHRNWRLRDAVGGEKSGEDASNGWQRRIFIEQIFQLAANGE-MTLEEIMDE 308
            ||.|.|.                   ||.:|. |.|      .::.:......|: ::..||.||
  Fly   248 AKELLDM-------------------GEPAGR-AHN------LLDTLLLAKFEGQSLSRREIRDE 286

  Fly   309 AQSMVLVSFETVSNSIMLALLCLATNKGDCQRRLLAEIRALVPDVGQVGLEQLQQLRYLDAFVSE 373
            ..:.|....:|.:.::...|..|| ...:.|.||..|::.:..| ....|:.|..|.||:|.:.|
  Fly   287 INTFVFAGVDTTTAAMSFVLYALA-KFPETQTRLRKELQDVALD-ETTDLDALNGLPYLEALIKE 349

  Fly   374 SLRLLATVPMNLRHVSRDFRLAGRQHETIVPQNSIVVLDTFNMQRDERWWGANARQFDPQRFLDQ 438
            .|||...||...|..::...:.||.:...|    .:.::.:.:..|:.:: .:...|.|:|:|.:
  Fly   350 VLRLYTIVPTTGRQTTQSTEIGGRTYCAGV----TLWINMYGLAHDKEYY-PDPYAFKPERWLPE 409

  Fly   439 EEEQLSKGHNDSGSGEKRRQRDRRHSYSFLPFSNGLRSCIGRRYGLFIMKVFLVKLITNFDFQSD 503
            :......                  ::|::|||.|...||||||.|.:||:...:|:..|..:..
  Fly   410 DGAVAPP------------------AFSYIPFSGGPHVCIGRRYSLLLMKLLTARLVREFQMELS 456

  Fly   504 FELEKLQFVENISLK 518
            .|...|:....:.||
  Fly   457 PEQAPLRLEAQMVLK 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp318a1	NP_727590.1	p450	42..503	CDD:299894	104/481 (22%)
Cyp311a1	NP_572780.3	p450	30..480	CDD:278495	109/504 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45442786
Domainoid	1	1.000	82	1.000	Domainoid score	I1949
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.740