DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp318a1 and Cyp4f39

DIOPT Version :9

Sequence 1:	NP_727590.1	Gene:	Cyp318a1 / 32172	FlyBaseID:	FBgn0030369	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	NP_796281.1	Gene:	Cyp4f39 / 320997	MGIID:	2445210	Length:	532	Species:	Mus musculus

Alignment Length:	489	Identity:	109/489 - (22%)
Similarity:	202/489 - (41%)	Gaps:	94/489 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 PLAVLVGTRVLLYIDDPAGMECVLNAPECLDKTFLQDGFF-------VRRGLLHARGQKWKLRRK 128
            ||.|||...   ||....|....: ||        :|.||       :..|||.::|.||...|:
Mouse   105 PLLVLVHPD---YIKPVLGASAAI-AP--------KDEFFYSFLKPWLGDGLLISKGNKWSRHRR 157

  Fly   129 QLNPAFSHNIVASFFDVFNSVGNQMVEQFQTQTNLHGQAVKFTAAE-------DLLSRAVLEVSC 186
            .|.|||..:|:..:..:||...|.|..:::... ..|....|...|       |.|.:.|
Mouse   158 LLTPAFHFDILKPYMKIFNQCTNIMHAKWRRHL-AEGSVTSFDMFEHISLMTLDSLQKCV----- 216

  Fly   187 LTIMGTPTNFTQLDDA--HIAHSYKRLLEISAVRVVKPWLQIRLLHRLLAPELY------EESKK 243
                     |:...|.  .::.....::|:||:.|.:   |.||.|.|  ..:|      ...::
Mouse   217 ---------FSYNSDCQERMSDYISSIIELSALVVRR---QYRLHHYL--DFMYYLTADGRRFRQ 267

  Fly   244 CAKLLEDFVGGIVRTKHRNWRLRDAVGGEKSGEDASNGWQRRIFIEQIFQLAAN---GEMTLEEI 305
            ....:.:|...:::.:.:..|.:.|....|:.:..:..     ||: :..||.:   .|::.|:|
Mouse   268 ACDTVHNFTTEVIQERRQALRQQGAEAWLKAKQGKTLD-----FID-VLLLAKDEEGKELSDEDI 326

  Fly   306 MDEAQSMVLVSFETVSNSIMLALLCLATNKGDCQRRLLAEIRALVP--DVGQVGLEQLQQLRYLD 368
            ..||.:.:....:|.|:.:..||..|| ...:.|.:...||:.::.  ::.::..:.|.||.:..
Mouse   327 RAEADTFMFEGHDTTSSGLSWALFNLA-KYPEYQEKCREEIQEVMKGRELEELDWDDLTQLPFTT 390

  Fly   369 AFVSESLRLLATVPMNLRHVSRDFRLA-GRQHETIVPQNSIVVLDTFNMQRDERWWGANARQFDP 432
            ..:.||||....|.:..|..:.|.:|. ||    ::|:..|.::..:....:...| .:::.::|
Mouse   391 MCIKESLRQFPPVTLISRRCTEDIKLPDGR----VIPKGIICLVSIYGTHHNPIVW-PDSKVYNP 450

  Fly   433 QRFLDQEEEQLSKGHNDSGSGEKRRQRDRRHSYSFLPFSNGLRSCIGRRYGLFIMKVFLVKLITN 497
            .|| |.:..|                  :|...:|:|||.|.|:|||:.:.:..|:|.:...:..
Mouse   451 YRF-DPDTPQ------------------QRSPLAFVPFSAGPRNCIGQSFAMAEMRVVVALTLLR 496

  Fly   498 FDFQSDFELEKLQFVENISLKFKNADDILLTIQP 531
            |....| ...|::....:.|:.:|.  :.|.::|
Mouse   497 FRLSVD-RTHKVRRKPELILRTENG--LWLNVEP 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp318a1	NP_727590.1	p450	42..503	CDD:299894	103/459 (22%)
Cyp4f39	NP_796281.1	p450	60..515	CDD:365848	105/473 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820