DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp318a1 and cyp19a1a

DIOPT Version :9

Sequence 1:	NP_727590.1	Gene:	Cyp318a1 / 32172	FlyBaseID:	FBgn0030369	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	NP_571229.3	Gene:	cyp19a1a / 30390	ZFINID:	ZDB-GENE-990415-43	Length:	517	Species:	Danio rerio

Alignment Length:	536	Identity:	115/536 - (21%)
Similarity:	199/536 - (37%)	Gaps:	143/536 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 ACGA-------LLAVLLAWQQRK---------------------CWRLIWQ--------LNGWRG 37
            ||||       ||.:|||.:..:                     | |.||.        .|...|
Zfish    39 ACGATATILLLLLCLLLAIRHHRPHKSHIPGPSFFFGLGPVVSYC-RFIWSGIGTASNYYNSKYG 102

  Fly    38 VIQQPVLWLLLCINLHPNSILEKVSQYRVHFQRPLAVLVGTRVLLY---IDDPAGMECVLNAPEC 99
            .|.:  :|    ||.....||.:.|          ||....|..||   .....|::|:
Zfish   103 DIVR--VW----INGEETLILSRSS----------AVYHVLRKSLYTSRFGSKLGLQCI------ 145

  Fly   100 LDKTFLQDGFFVRRGLLHARGQKWKLRRKQLNPAFSHNIVASFFDVFNSVGNQMVEQFQTQTNLH 164
                    |...:..:.::....||..|.....|.:...:....::..:..|..::.....|:..
Zfish   146 --------GMHEQGIIFNSNVALWKKVRAFYAKALTGPGLQRTMEICTTSTNSHLDDLSQLTDAQ 202

  Fly   165 GQAVKFTAAEDLLSRAVLEVSCLTIMGTPTNFTQLDDAHIAHSYKRLLEISAVRVVKPWLQIRLL 229
            ||    ....:||...|::||....:|.|.|  :.|.....|.|   .:.....::||.:..||
Zfish   203 GQ----LDILNLLRCIVVDVSNRLFLGVPLN--EHDLLQKIHKY---FDTWQTVLIKPDVYFRL- 257

  Fly   230 HRLLAPELYEESKKCAKLLEDFVGGIVRTKHRNWRLRDAVGGEKSGEDASNGWQRRIFIEQIFQL 294
                 ..|:::.|:.|:.|:|.:..::..|    :::.|...:....|         |..::...
Zfish   258 -----DWLHKKHKRDAQELQDAITALIEQK----KVQLAHAEKLDHLD---------FTAELIFA 304

  Fly   295 AANGEMTLEEIMDEAQSMVLVSFETVSNSIMLALLCLATNKGDCQRRLLAEIRALVPDVGQ-VGL 358
            .::||::.|.:......||:.:.:|:|.|:...||.|..|. |.:.::|.|:.:::  .|| :..
Zfish   305 QSHGELSAENVRQCVLEMVIAAPDTLSISLFFMLLLLKQNP-DVELKILQEMDSVL--AGQSLQH 366

  Fly   359 EQLQQLRYLDAFVSESLRLLATVPMNLRHVSRDFRLAGRQHETIVPQNSIVVLDTFNMQRDERWW 423
            ..|.:|:.|::|::||||....|...:|....|..:.|..    |.:.:.::|:...|.|.|.:.
Zfish   367 SHLSKLQILESFINESLRFHPVVDFTMRRALDDDVIEGYN----VKKGTNIILNVGRMHRSEFFS 427

  Fly   424 GANARQFD------PQRFLDQEEEQLSKGHNDSGSGEKRRQRDRRHSYSFLPFSNGLRSCIGRRY 482
            ..|....|      |.||                               |.||.:|.|||:|:..
Zfish   428 KPNQFSLDNFHKNVPSRF-------------------------------FQPFGSGPRSCVGKHI 461

  Fly   483 GLFIMKVFLVKLITNF 498
            .:.:||..||.|::.|
Zfish   462 AMVMMKSILVALLSRF 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp318a1	NP_727590.1	p450	42..503	CDD:299894	99/467 (21%)
cyp19a1a	NP_571229.3	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010