DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp318a1 and Cyp4f6

DIOPT Version :9

Sequence 1:	NP_727590.1	Gene:	Cyp318a1 / 32172	FlyBaseID:	FBgn0030369	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	XP_006241111.1	Gene:	Cyp4f6 / 266689	RGDID:	708365	Length:	538	Species:	Rattus norvegicus

Alignment Length:	540	Identity:	134/540 - (24%)
Similarity:	223/540 - (41%)	Gaps:	113/540 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 HLNIALWACGALLAVLLAWQQR---KCWRLIWQLNGWRGVIQQP-VLWLLLCINLHPNSILEKVS 62
            || :.|.....:||.:|||...   .|.||       |...|.| ..|....:.|..|:  |:..
  Rat    21 HL-LLLGGASWILARILAWIYTFYDNCCRL-------RCFPQPPKPSWFWGHLTLMKNN--EEGM 75

  Fly    63 QYRVHFQR--------------PLAVLVGTRVLLYIDDPAGMECVLNAPECLD-----KTFLQDG 108
            |:..|..|              |:..||...|:.    |........||:.:.     |.:|.|
  Rat    76 QFIAHLGRNFRDIHLSWVGPVYPILRLVHPNVIA----PLLQASAAVAPKEMTLYGFLKPWLGD- 135

  Fly   109 FFVRRGLLHARGQKWKLRRKQLNPAFSHNIVASFFDVFNSVGNQMVEQFQTQTNLHGQAVKFTAA 173
                 |||.:.|:||...|:.|.|||..:|:.|:..:||...|.|..::|..|      .|.:|.
  Rat   136 -----GLLMSAGEKWNHHRRLLTPAFHFDILKSYVKIFNKSVNTMHAKWQRLT------AKGSAR 189

  Fly   174 EDLLSRAVLEVSCLT-------IMGTPTNFTQLDDAHIAHSYKRLLEISAVRVVK----PWLQIR 227
            .|:..    .:|.:|       |....:|..:.:..:||    .:||:|:: :||    |:|.:.
  Rat   190 LDMFE----HISLMTLDSLQKCIFSFDSNCQESNSEYIA----AILELSSL-IVKRQRQPFLYLD 245

  Fly   228 LLHRLLAPELYEESKKCAKLLEDFVGGIVRTKHRNWRLRDAVGGEKSGE--DASNGWQRRIFIEQ 290
            .|:.|.|..  ...:|...::.:|...::|.:      |..:..:...|  .|....:...||:.
  Rat   246 FLYYLTADG--RRFRKACDVVHNFTDAVIRER------RSTLNTQGVDEFLKARAKTKTLDFIDV 302

  Fly   291 IFQLAANGE----MTLEEIMDEAQSMVLVSFETVSNSIMLALLCLATNKGDCQRRLLAEIRALVP 351
            :  |.|..|    ::..:|..||.:.:....:|.::::...|..||.:. :.|.|...|:|.|:.
  Rat   303 L--LLAKDEHGKGLSDVDIRAEADTFMFGGHDTTASALSWILYNLARHP-EYQERCRQEVRELLR 364

  Fly   352 D--VGQVGLEQLQQLRYLDAFVSESLRLLATVPMNLRHVSRDFRLA-GRQHETIVPQNSIVVLDT 413
            |  ..::..:.|.||.:|...:.|||||...|.:..|..|:|..|. ||    ::|:.:|.|:..
  Rat   365 DREPEEIEWDDLAQLPFLTMCIKESLRLHPPVLLISRCCSQDIVLPDGR----VIPKGNICVISI 425

  Fly   414 FNMQRDERWWGANARQFDPQRFLDQEEEQLSKGHNDSGSGEKRRQRDRRHSYSFLPFSNGLRSCI 478
            |.:..:...| .:...::|.|| |.|..|                  :|...:|:|||.|.|:||
  Rat   426 FGVHHNPSVW-PDPEVYNPFRF-DPENPQ------------------KRSPLAFIPFSAGPRNCI 470

  Fly   479 GRRYGLFIMKVFLVKLITNF 498
            |:.:.:..:||.|...:..|
  Rat   471 GQTFAMSEIKVALALTLLRF 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp318a1	NP_727590.1	p450	42..503	CDD:299894	121/497 (24%)
Cyp4f6	XP_006241111.1	p450	53..515	CDD:278495	122/500 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820