DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp318a1 and Cyp4x1

DIOPT Version :9

Sequence 1:	NP_727590.1	Gene:	Cyp318a1 / 32172	FlyBaseID:	FBgn0030369	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	NP_663708.1	Gene:	Cyp4x1 / 246767	RGDID:	628719	Length:	507	Species:	Rattus norvegicus

Alignment Length:	521	Identity:	126/521 - (24%)
Similarity:	221/521 - (42%)	Gaps:	76/521 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LNIALWACGALL---AVLLAWQQRKCWRLIWQLNGWRGVIQQPVLWLLLCINLHPNSILEKVSQY 64
            |::||..|.||:   ||.|..:::   ||:..|..:.|....   |||..........:||:.:.
  Rat    14 LHLALVFCLALVLMQAVKLYLRRQ---RLLRDLRPFPGPTAH---WLLGHQKFLQEDNMEKLDEI 72

  Fly    65 RVHFQRPLAVLVGT-RVLLYIDDPAGMECVLNAPECLDKT-FLQDGF--FVRRGLLHARGQKWKL 125
            ...:.......||. :...||.||...:..|:..:  .|| :|....  |:.||||:..|.:|..
  Rat    73 VKEYPCAFPCWVGPFQAFFYIYDPDYAKIFLSRTD--PKTQYLHQLMTPFLGRGLLNLDGPRWFQ 135

  Fly   126 RRKQLNPAFSHNIVASFFDVFNSVGNQMVEQFQTQTNLHGQAVKFTAAEDLLSRAVLEVSCLTIM 190
            .|..|.|||..:|:....|:.....|.|:::::.........::.....:|::   |::......
  Rat   136 HRCLLTPAFHQDILKPCVDMMAHSVNMMLDKWEKTWTTQETTIEVFEHINLMT---LDIIMKCAF 197

  Fly   191 GTPTNFTQLDDAHIAHSYKR----LLEISAVRVVKPWLQIRLLHRLLAP------ELYEESKKCA 245
            |..|| .|::..:  .||.:    |.||.:.|:...|....::.: |:|      ||.:...:|.
  Rat   198 GQETN-CQINGTY--ESYVKATFELGEIISSRLYNFWHHHDIIFK-LSPKGHCFQELGKVIHQCT 258

  Fly   246 -KLLEDFVGGIVRTKHRNWRLRDAVGGEKSGEDASNGWQRRIFIEQIFQLAANGEMTLE--EIMD 307
             |:::|          |...|:|.|..:.: :.:.|      |::.:....|..|....  ::..
  Rat   259 EKIIQD----------RKKTLKDQVNQDDT-QTSQN------FLDIVLSAQAGDEKAFSDADLRS 306

  Fly   308 EAQSMVLVSFETVSNSIMLALLCLATNKGDCQRRLLAEIRALVPDVGQVGLEQLQQLRYLDAFVS 372
            |..:.:....:..:.||...|.|||.|. :.|.|...|||:::.|...:..|||.::.|....:.
  Rat   307 EVNTFMWAGHDASAASISWLLYCLALNP-EHQDRCRTEIRSILGDGSSITWEQLDEIPYTTMCIK 370

  Fly   373 ESLRLLATVPMNLRHVSRDFRLAGRQHETIVPQNSIVVLDTFNMQRDERWWGANARQFDPQRFLD 437
            |:|||:..:|...|.:|:...|.....   :|....|||..:.:..:...| .:.:.|||.||..
  Rat   371 ETLRLIPPIPSISRELSKPLTLPDGHS---LPAGMTVVLSIWGLHHNPAVW-KDPKVFDPLRFTK 431

  Fly   438 QEEEQLSKGHNDSGSGEKRRQRDRRHSYSFLPFSNGLRSCIGRRYGLFIMKVFLVKLITNFDFQS 502
            :..||                   ||..:|||||:|.|:|||:::.:..:||.:...:..|...:
  Rat   432 ENSEQ-------------------RHPCAFLPFSSGPRNCIGQQFAMLELKVAIALTLLRFRVAA 477

  Fly   503 D 503
            |
  Rat   478 D 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp318a1	NP_727590.1	p450	42..503	CDD:299894	112/477 (23%)
Cyp4x1	NP_663708.1	CYP4B-like	66..500	CDD:410771	110/463 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.880