DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp318a1 and Cyp4b1

DIOPT Version :9

Sequence 1:	NP_727590.1	Gene:	Cyp318a1 / 32172	FlyBaseID:	FBgn0030369	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	NP_058695.2	Gene:	Cyp4b1 / 24307	RGDID:	2480	Length:	511	Species:	Rattus norvegicus

Alignment Length:	571	Identity:	131/571 - (22%)
Similarity:	220/571 - (38%)	Gaps:	123/571 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 IALWACGALLAVL------LAWQQRKCWRLIWQLNGWRGVIQQPVLWLL-LCINLHPNSILEKVS 62
            :.|||...:|.|:      |..:::|..|.:....|      .|..||. ..:.:.....|:||.
  Rat    13 LGLWASVVILMVIVLKLFSLLLRRQKLARAMDSFPG------PPTHWLFGHALEIQKLGSLDKVV 71

  Fly    63 QYRVHFQRPLAVLVGTRV-LLYIDDPAGMECVLNA--PECLD--KTFLQDGFFVRRGLLHARGQK 122
            .:...|.....:..|..| .|.|.:|...:.|.:.  |:..|  ..|||   ::.:|||...|.|
  Rat    72 SWAQQFPHAHPLWFGQFVGFLNIYEPDYAKAVYSRGDPKAADVYDFFLQ---WIGKGLLVLDGPK 133

  Fly   123 WKLRRKQLNPAFSHNI----VASF--------------------FDVFNSVGNQMVEQFQTQTNL 163
            |...||.|.|.|.:::    ||.|                    ||:|..||:..::.....|
  Rat   134 WFQHRKLLTPGFHYDVLKPYVAIFAESTRMMLDKWEKKASENKSFDIFCDVGHMALDTLMKCT-- 196

  Fly   164 HGQAVKFTAAEDLLSRAVLEVSCLTIMGTPTNFTQLDDAHIAHS---YKRLLEISAVRVVKPWLQ 225
            .|:........|  :...|.||.||::     ..|..|:...|:   |              |
  Rat   197 FGKGDSGLGHRD--NSYYLAVSDLTLL-----MQQRIDSFQYHNDFIY--------------W-- 238

  Fly   226 IRLLHRLLAPELYEESKKCAKLLEDFVGGIVRTKHRNWRLRDAVGGEKSGEDASNGWQRR--IFI 288
                   |.|......:.| |:..|....::|.:      :.|:..||..:...   |||  .|:
  Rat   239 -------LTPHGRRFLRAC-KIAHDHTDEVIRQR------KAALQDEKERKKIQ---QRRHLDFL 286

  Fly   289 EQIFQLAANGEMTLE--EIMDEAQSMVLVSFETVSNSIMLALLCLATNKGDCQRRLLAEIRALVP 351
            :.:..:.....:.|.  |:..|..:.:....:|.::.|...|.|:|... :.|:....|:|.::.
  Rat   287 DILLGVRDESGIKLSDAELRAEVDTFMFEGHDTTTSGISWFLYCMALYP-EHQQLCREEVRGILG 350

  Fly   352 DVGQVGLEQLQQLRYLDAFVSESLRLLATVPMNLRHVSRDFRLA-GRQHETIVPQNSIVVLDTFN 415
            |......:.|.::.||...:.|..||...||...|.:::..... ||.    :|..|::.|..:.
  Rat   351 DQDSFQWDDLAKMTYLTMCMKECFRLYPPVPQVYRQLNKPVTFVDGRS----LPAGSLISLHIYA 411

  Fly   416 MQRDERWWGANARQFDPQRFLDQEEEQLSKGHNDSGSGEKRRQRDRRHSYSFLPFSNGLRSCIGR 480
            :.|:...| .:...|||.||..:         |.:|          ||.::|:|||.|.|:|||:
  Rat   412 LHRNSTVW-PDPEVFDPLRFSPE---------NAAG----------RHPFAFMPFSAGPRNCIGQ 456

  Fly   481 RYGLFIMKVFLVKLITNFDFQSDFELEKLQFVENISLKFKNADDILLTIQP 531
            ::.:..|||.....:..|:|..|.....:: |..:.|:.||.  |.|.::|
  Rat   457 QFAMNEMKVVTALCLLRFEFSLDPSKMPIK-VPQLILRSKNG--IHLYLKP 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp318a1	NP_727590.1	p450	42..503	CDD:299894	114/498 (23%)
Cyp4b1	NP_058695.2	p450	47..500	CDD:278495	121/531 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.780