Protein Alignment Cyp318a1 and CYP3A7

DIOPT Version :10

• Sequence 1: NP_727590.1
• Gene: Cyp318a1 / 32172
• FlyBaseID: FBgn0030369
• Length: 536
• Species: Drosophila melanogaster
• Sequence 2: NP_000756.3
• Gene: CYP3A7 / 1551
• HGNCID: 2640
• Length: 503
• Species: Homo sapiens
• Alignment Length: 559
• Identity: 128/559 - (22%)
• Similarity: 229/559 - (40%)
• Gaps: 143/559 - (25%)

  Fly    45 WLLLCINLHPNSILEKVSQYRVH--FQR-------PLAVLVGT---------------------- 78
            ||||.::|    ||..:...|.|  |::       ||..|...
Human    12 WLLLAVSL----ILLYLYGTRTHGLFKKLGIPGPTPLPFLGNALSFRKGYWTFDMECYKKYRKVW 72

  Fly    79 ------RVLLYIDDPAGMECVLNAPECLD-----KTFLQDGFFVRRGLLHARGQKWKLRRKQLNP 132
                  :.:|.|.||..::.|| ..||..     :.|...| |::..:..|..::||..|..|:|
Human    73 GIYDCQQPMLAITDPDMIKTVL-VKECYSVFTNRRPFGPVG-FMKNAISIAEDEEWKRIRSLLSP 135

  Fly   133 AFSHNIVASFFDVFNSVGNQMVEQFQTQTNLHGQAVKFTAAEDLLSRAVLEVSCLTIMGTPTNF- 196
            .|:...:.....:....|:.:|...:.:... |:.|.........|..|:         |.|:|
Human   136 TFTSGKLKEMVPIIAQYGDVLVRNLRREAET-GKPVTLKHVFGAYSMDVI---------TSTSFG 190

  Fly   197 TQLDDAH-----IAHSYKRLLE-------ISAVRVVKPWLQ--IRLLHRLLAP-ELYEESKKCAK 246
            ..:|..:     ...:.|:||.       :.:::|. |:|.  :..|:..:.| ::.....|..|
Human   191 VSIDSLNNPQDPFVENTKKLLRFNPLDPFVLSIKVF-PFLTPILEALNITVFPRKVISFLTKSVK 254

  Fly   247 LLEDFVGGIVRT-KHRNWRLRDAVGGEKSGEDASNGWQRRIFIEQIFQLAANGEMTLEEIMDEAQ 310
            .:::  |.:..| |||...|:..:..:.|.:..::                   ..|.::...||
Human   255 QIKE--GRLKETQKHRVDFLQLMIDSQNSKDSETH-------------------KALSDLELMAQ 298

  Fly   311 SMVLV--SFETVSNSIMLALLCLATNKGDCQRRLLAEIRALVPDVGQVGLEQLQQLRYLDAFVSE 373
            |::.:  .:||.|:.:...:..|||:. |.|:::..||..::|:......:.:.||.|||..|:|
Human   299 SIIFIFAGYETTSSVLSFIIYELATHP-DVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVVNE 362

  Fly   374 SLRLLATVPMNLRHV-SRDFRLAGRQHETIVPQNSIVVLDTFNMQRDERWWGANARQFDPQRFLD 437
            :|||. .|.|.|..| .:|..:.|    ..:|:..:|::.::.:..|.::|      .:|::||
Human   363 TLRLF-PVAMRLERVCKKDVEING----MFIPKGVVVMIPSYVLHHDPKYW------TEPEKFL- 415

  Fly   438 QEEEQLSKGHNDSGSGEKRRQRDRRHSYSFLPFSNGLRSCIGRRYGLFIMKVFLVKLITNFDFQS 502
              .|:.||           :.:|....|.:.||.:|.|:|||.|:.|..||:.||:::.||.|:.
Human   416 --PERFSK-----------KNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKP 467

  Fly   503 DFELE---KLQFVENISLKFKNADDILLTIQP---KKES 535
            ..|.:   ||:|           ..:|||.:|   |.||
Human   468 CKETQIPLKLRF-----------GGLLLTEKPIVLKAES 495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp318a1	NP_727590.1	CYP313-like	69..525	CDD:410680	111/518 (21%)
CYP3A7	NP_000756.3	CYP3A	67..492	CDD:410743	112/495 (23%)