Protein Alignment Cyp318a1 and CYP3A7-CYP3A51P

DIOPT Version :10

• Sequence 1: NP_727590.1
• Gene: Cyp318a1 / 32172
• FlyBaseID: FBgn0030369
• Length: 536
• Species: Drosophila melanogaster
• Sequence 2: NP_001243426.2
• Gene: CYP3A7-CYP3A51P / 100861540
• HGNCID: 51504
• Length: 535
• Species: Homo sapiens
• Alignment Length: 558
• Identity: 126/558 - (22%)
• Similarity: 232/558 - (41%)
• Gaps: 135/558 - (24%)

  Fly    45 WLLLCINLHPNSILEKVSQYRVH--FQR-------PLAVLVGT---------------------- 78
            ||||.::|    ||..:...|.|  |::       ||..|...
Human    12 WLLLAVSL----ILLYLYGTRTHGLFKKLGIPGPTPLPFLGNALSFRKGYWTFDMECYKKYRKVW 72

  Fly    79 ------RVLLYIDDPAGMECVLNAPECLD-----KTFLQDGFFVRRGLLHARGQKWKLRRKQLNP 132
                  :.:|.|.||..::.|| ..||..     :.|...| |::..:..|..::||..|..|:|
Human    73 GIYDCQQPMLAITDPDMIKTVL-VKECYSVFTNRRPFGPVG-FMKNAISIAEDEEWKRIRSLLSP 135

  Fly   133 AFSHNIVASFFDVFNSVGNQMVEQFQTQTNLHGQAVKFTAAEDLLSRAVLEVSCLTIMGTPTNF- 196
            .|:...:.....:....|:.:|...:.:... |:.|.........|..|:         |.|:|
Human   136 TFTSGKLKEMVPIIAQYGDVLVRNLRREAET-GKPVTLKHVFGAYSMDVI---------TSTSFG 190

  Fly   197 TQLDDAH-----IAHSYKRLLE-------ISAVRVVKPWLQ--IRLLHRLLAP-ELYEESKKCAK 246
            ..:|..:     ...:.|:||.       :.:::|. |:|.  :..|:..:.| ::.....|..|
Human   191 VSIDSLNNPQDPFVENTKKLLRFNPLDPFVLSIKVF-PFLTPILEALNITVFPRKVISFLTKSVK 254

  Fly   247 LLEDFVGGIVRT-KHRNWRLRDAVGGEKSGEDASNGWQRRIFIEQIFQLAANGEMTLEEIMDEAQ 310
            .:::  |.:..| |||...|:..:..:.|.:..::                   ..|.::...||
Human   255 QIKE--GRLKETQKHRVDFLQLMIDSQNSKDSETH-------------------KALSDLELMAQ 298

  Fly   311 SMVLV--SFETVSNSIMLALLCLATNKGDCQRRLLAEIRALVPDVGQVGLEQLQQLRYLDAFVSE 373
            |::.:  .:||.|:.:...:..|||:. |.|:::..||..::|:......:.:.||.|||..|:|
Human   299 SIIFIFAGYETTSSVLSFIIYELATHP-DVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVVNE 362

  Fly   374 SLRLLATVPMNLRHV-SRDFRLAGRQHETIVPQNSIVVLDTFNMQRDERWWGANARQFDPQRFLD 437
            :|||. .|.|.|..| .:|..:.|    ..:|:..:|::.::.:..|.::|      .:|::||
Human   363 TLRLF-PVAMRLERVCKKDVEING----MFIPKGVVVMIPSYVLHHDPKYW------TEPEKFL- 415

  Fly   438 QEEEQLSKGHNDSGSGEKRRQRDRRHSYSFLPFSNGLRSCIGRRYGLFIMKVFLVKLITNFDFQS 502
              .|:.||           :.:|....|.:.||.:|.|:|||.|:.|..||:.||:::.||.|:.
Human   416 --PERFSK-----------KNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKP 467

  Fly   503 DFELE---KLQF------VENISLKFKNADDILLTIQP 531
            ..|.:   ||:|      .:.|.||.::.|:..:.::|
Human   468 CKETQIPLKLRFGGLLLTEKPIVLKAESRDETFVDMEP 505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp318a1	NP_727590.1	CYP313-like	69..525	CDD:410680	115/524 (22%)
CYP3A7-CYP3A51P	NP_001243426.2	CYP3A	67..492	CDD:410743	109/484 (23%)