DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp318a1 and cyp4f3

DIOPT Version :9

Sequence 1:	NP_727590.1	Gene:	Cyp318a1 / 32172	FlyBaseID:	FBgn0030369	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	NP_001083010.1	Gene:	cyp4f3 / 100037390	ZFINID:	ZDB-GENE-070410-108	Length:	511	Species:	Danio rerio

Alignment Length:	528	Identity:	121/528 - (22%)
Similarity:	220/528 - (41%)	Gaps:	94/528 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LNIALWACGALLAVLLAWQQRKCWRLIWQLNGWRGVIQQPVL--WLLLCINL--HPNSILEKVSQ 63
            |::|...|..:..:::..:..:|:             .||.|  |::..:.|  |....|::|..
Zfish    13 LSVAALLCALVTRIIINRRALRCF-------------NQPPLRNWIMGHMGLMGHNEEGLQRVDD 64

  Fly    64 YRVHFQRPLAVLVG---TRVLLYIDDPAGMECVLNAPECL---DKTFLQDGF---FVRRGLLHAR 119
            ....:....:..:|   ..|.|:  .|..:..:|.|...:   |:.|.  ||   ::...||...
Zfish    65 LVCKYGHSCSWFLGPFYNMVRLF--HPDYIRSLLTASASITLKDRIFY--GFMKPWLGNCLLLQS 125

  Fly   120 GQKWKLRRKQLNPAFSHNIVASFFDVFNSVGNQMVEQFQTQTNLHGQAVKFTAAEDLLSRAVLEV 184
            ||:|...|:.|.|||..:|:..:..:||...|.|.::::.      ...|...:.|:..    ::
Zfish   126 GQEWSRHRRLLTPAFHFDILKKYVHIFNQSTNIMHDEWRR------LLAKGEHSVDMFE----QI 180

  Fly   185 SCLTIMGTPTNFTQLDDAHIAHSYKR----LLEISAVRVVK--------PWLQIRLLHRLLAPEL 237
            |.|| :.:....|...|.|.....::    :|::|.:.|.:        .||..|      :.:.
Zfish   181 SSLT-LDSLLKCTFSCDTHSQEKPRQYISAILDLSRLLVQRQHYLPYHWDWLYWR------SAQG 238

  Fly   238 YEESKKCAKLLEDFVGGIVRTKHRNWRLRDAVGGEKSGEDASNGWQRRIFIEQIFQLAA----NG 298
            ....:.|| ::..|...||  :.|..:| |.....:|..:.:..:::|...:.|..|..    .|
Zfish   239 RRFQQACA-VVHQFTADIV--QERRTQL-DQQSDPESHPENTGRYRKRKNTDLIDLLLLAKDDKG 299

  Fly   299 E-MTLEEIMDEAQSMVLVSFETVSNSIMLALLCLATNKGDCQRRLLAEIRALVP--DVGQVGLEQ 360
            | :|.|||...|...:....:|.::::......||.|: |.|.|..||:|.|:.  |...:|.|.
Zfish   300 EGLTNEEIKAHADMFMFAGHDTTASALSWIFYNLAMNQ-DYQERCRAEVRDLLADRDTHTIGWED 363

  Fly   361 LQQLRYLDAFVSESLRLLATVPMNLRHVSRDFRLAGRQHETIVPQNSIVVLDTFNMQRDERWWGA 425
            |.||.:....:.|||||.:.|....|:.|::.:..|   :.::|...:.::..:.:.|:.:.| .
Zfish   364 LSQLTFTTMCIKESLRLHSPVLALTRYYSQNMKTPG---DCVIPHGCLCLISIYGVHRNPQVW-P 424

  Fly   426 NARQFDPQRFLDQEEEQLSKGHNDSGSGEKRRQRDRRHSYSFLPFSNGLRSCIGRRYGLFIMKVF 490
            :...|||.||         ..||.          |.|..::|:|||.|.|:|||:.:.:..|||.
Zfish   425 DPLVFDPTRF---------DPHNS----------DSRSPHAFIPFSAGPRNCIGQNFAMAEMKVV 470

  Fly   491 LVKLITNF 498
            :...:..|
Zfish   471 VALTLARF 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp318a1	NP_727590.1	p450	42..503	CDD:299894	116/489 (24%)
cyp4f3	NP_001083010.1	p450	38..503	CDD:278495	117/490 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010