DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp311a1 and CYP4F2

DIOPT Version :9

Sequence 1:	NP_572780.3	Gene:	Cyp311a1 / 32170	FlyBaseID:	FBgn0030367	Length:	483	Species:	Drosophila melanogaster
Sequence 2:	NP_001073.3	Gene:	CYP4F2 / 8529	HGNCID:	2645	Length:	520	Species:	Homo sapiens

Alignment Length:	514	Identity:	154/514 - (29%)
Similarity:	248/514 - (48%)	Gaps:	48/514 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MALWP-------LLLITLTIWIL--VRKWTL-----LRLGSSLPGP----WAFPLLGNAQMVGKL 47
            :.|||       |||:....|:|  |..||.     .|.....|.|    |.:   |:..||..
Human     9 LGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFW---GHQGMVNP- 69

  Fly    48 RPEYIFLVFTELRDRFGATYRLRLGP--QLWVFLHSAEETRQALH-DPTLRKADTFMQ--LEPLI 107
             .|....|.|:|...:...:::.:||  .|....| .:..|..:: ...:...|.|..  |||.:
Human    70 -TEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCH-PDIIRSVINASAAIAPKDKFFYSFLEPWL 132

  Fly   108 GNGLLISHGAHWTRQRRLLTPAFQPQLLRSFAPAIGGHVERLVGR---LGATRGAFLEVTEPLFA 169
            |:|||:|.|..|:|.||:|||||...:|:.:.......|..:..:   |.:...|.|::.|.:..
Human   133 GDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISL 197

  Fly   170 CLLDAIVDTSMGAQLDTQSVDHSPIIQAFHLSSKLLFKRMINPLLSSDWIFQRTQLWRDLDEQLQ 234
            ..||::...........|......|.....||: |:.||....||..|:::..|...:......:
Human   198 MTLDSLQKCVFSFDSHCQEKPSEYIAAILELSA-LVSKRHHEILLHIDFLYYLTPDGQRFRRACR 261

  Fly   235 VIHSQMESVIEKRAKELLDMG-------EPAGRAHNLLDTLLLAKFE-GQSLSRREIRDEINTFV 291
            ::|...::||::|.:.|...|       :...:..:.:|.|||:|.| |:.||..:||.|.:||:
Human   262 LVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFM 326

  Fly   292 FAGVDTTTAAMSFVLYALAKFPETQTRLRKELQDVALD---ETTDLDALNGLPYLEALIKEVLRL 353
            |.|.|||.:.:|:|||.|||.||.|.|.|:|:|::..|   :..:.|.|..||:|...:||.|||
Human   327 FEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRL 391

  Fly   354 YTIVPTTGRQTTQSTEI-GGRTYCAGVTLWINMYGLAHDKEYYPDPYAFKPERWLPEDGAVAPPA 417
            :..||...|..||...: .||....|:...|:::|..|:...:|||..:.|.|:.||:.....|
Human   392 HPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSP- 455

  Fly   418 FSYIPFSGGPHVCIGRRYSLLLMKLLTARLVREFQMELSPEQAPLRLEAQMVLKAQQGI 476
            .::||||.||..|||:.:::..||::.|..:..|:  :.|:....|.:.::||:|:.|:
Human   456 LAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFR--VLPDHTEPRRKPELVLRAEGGL 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp311a1	NP_572780.3	p450	30..480	CDD:278495	142/471 (30%)
CYP4F2	NP_001073.3	DUF4175	4..>57	CDD:372724	14/47 (30%)
CYP4F2	NP_001073.3	p450	52..515	CDD:365848	142/471 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.810