Protein Alignment Cyp311a1 and TBXAS1

DIOPT Version :10

• Sequence 1: NP_572780.3
• Gene: Cyp311a1 / 32170
• FlyBaseID: FBgn0030367
• Length: 483
• Species: Drosophila melanogaster
• Sequence 2: NP_001159725.2
• Gene: TBXAS1 / 6916
• HGNCID: 11609
• Length: 579
• Species: Homo sapiens
• Alignment Length: 613
• Identity: 143/613 - (23%)
• Similarity: 228/613 - (37%)
• Gaps: 181/613 - (29%)

  Fly     5 PLLLITLTIWIL-VRKW-------TLLRLGSSLPGPWAFPLLGN----------AQMVGKLRPEY 51
            |::.:.|::.:| :.||       .|.:||...|.|  .|.:||          :||
Human    14 PMVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKP--SPFIGNLTFFRQGFWESQM-------- 68

  Fly    52 IFLVFTELRDRFGATYRLRLGPQLWVFLHSAEETRQALHDPTLRKADTFMQLEPLIGNGL----- 111
                  |||..:|......||.::::.:...:..:|.|       .:.|......:.:||
Human    69 ------ELRKLYGPLCGYYLGRRMFIVISEPDMIKQVL-------VENFSNFTNRMASGLEFKSV 120

  Fly   112 ----LISHGAHWTRQRRLLTPAFQPQLLRSFAPAIGGHVERLVGRLGA---------TR-----G 158
                |......|...|..|..||.|:.|......|  ..||:.|.:|.         ||     |
Human   121 ADSVLFLRDKRWEEVRGALMSAFSPEKLNELGLLI--MQERIKGHMGGQQAPQRIPPTRLSKPSG 183

  Fly   159 AFLEV--------TEPLF--ACLL--------------------------DAIVDTSMGAQLDTQ 187
            .::.:        ..||.  ||.|                          |.:...:.|..:|:.
Human   184 IYVNLHYATLPFCMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGTPVDSW 248

  Fly   188 SVDHSPIIQ------AFHLSSKLL-----FKRMINPLLSSDWIFQRTQLWRDLDEQLQVIHSQME 241
            .....|.::      .|.:...:|     |..::.||       .|....::.||.....:..:.
Human   249 QAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPL-------ARILPNKNRDELNGFFNKLIR 306

  Fly   242 SVI--------EKRAKELLDM-------GEPAG---------------------RAHNLLDTLLL 270
            :||        |:|.::.|.|       ..|.|                     |.|
Human   307 NVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSRQH-------- 363

  Fly   271 AKFEGQSLSRREIRDEI--NTFVF--AGVDTTTAAMSFVLYALAKFPETQTRLRKELQDVALD-- 329
               :...::|....|||  ..|:|  ||.:..|..:||..|.||..|:.|.:|.:|: ||..:
Human   364 ---QPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREV-DVFKEKH 424

  Fly   330 ---ETTDLDALNGLPYLEALIKEVLRLYTIVPTTGRQTTQSTEIGGRTYCAGVTLWINMYGLAHD 391
               |...|:  .|||||:.:|.|.||:|.......|:..|..|:.|:...||..|.:.:..|.||
Human   425 MAPEFCSLE--EGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHD 487

  Fly   392 KEYYPDPYAFKPERWLPEDGAVAPPAFSYIPFSGGPHVCIGRRYSLLLMKLLTARLVREFQMELS 456
            .|::|.|..|.|||:..|......| |:|:||..||..|:|.|..||.:||....::.:|:.:..
Human   488 PEHWPSPETFNPERFTAEARQQHRP-FTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQAC 551

  Fly   457 PE-QAPLRLEAQMVLKAQQGINVSFLKQ 483
            || |.||:||::..|..:.|:.:..:.:
Human   552 PETQVPLQLESKSALGPKNGVYIKIVSR 579

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp311a1	NP_572780.3	cytochrome_P450	64..478	CDD:477761	125/529 (24%)
TBXAS1	NP_001159725.2	cytochrome_P450	73..573	CDD:477761	125/530 (24%)