DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp311a1 and Cyp4f37

DIOPT Version :9

Sequence 1:	NP_572780.3	Gene:	Cyp311a1 / 32170	FlyBaseID:	FBgn0030367	Length:	483	Species:	Drosophila melanogaster
Sequence 2:	XP_038935973.1	Gene:	Cyp4f37 / 691312	RGDID:	1585102	Length:	526	Species:	Rattus norvegicus

Alignment Length:	505	Identity:	159/505 - (31%)
Similarity:	238/505 - (47%)	Gaps:	41/505 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 WPLLLITLTIWILVR--KWTL--------LRLGSSLP-GPWAFPLLGNAQMVGKLRPEYIFLVFT 57
            |.|||:....|||.|  .||.        ||.....| ..|....||..|.    ..|.:.|| |
  Rat    19 WHLLLLGAASWILARILAWTYSFCENCSRLRCFPQSPKRNWFLGHLGVIQS----NEEGMQLV-T 78

  Fly    58 ELRDRFGATYRLRLGPQLWVF-LHSAEETRQALHDPTL--RKADTFMQ-LEPLIGNGLLISHGAH 118
            |:...|...:.:.|||...|. |.........|..|.|  .|..||:. |:|.:|:||.:|.|..
  Rat    79 EMGQTFRDVHLIWLGPVSPVLRLVDPAFVAPLLQAPALVAPKDPTFLHFLKPWLGDGLFLSSGDK 143

  Fly   119 WTRQRRLLTPAFQPQLLRSFAPAIGGHVERLVGR---LGATRGAFLEVTEPLFACLLDAIVDTSM 180
            |:|.||||||||...:|:.:.......|..:..:   |.....|.||:.|.:....||::.....
  Rat   144 WSRHRRLLTPAFHFDILKPYVKTFNQSVNIMHAKWKHLCLEGSARLEMFENISLMTLDSLQKCLF 208

  Fly   181 GAQLDTQSVDHSPIIQAFHLSSKLLFKRMINPLLSSDWIFQRTQLWRDLDEQLQVIHSQMESVIE 245
            |...:.|......|.....||| |..||.....|..|:::.||...:...:...::||..::||.
  Rat   209 GFDSNCQESPSEYISATLELSS-LTRKRSYKLFLYLDFLYYRTADGQRFRKACDLVHSFTDAVIR 272

  Fly   246 KRAKELLDMG---------EPAGRAHNLLDTLLLAKFE-GQSLSRREIRDEINTFVFAGVDTTTA 300
            :|.:.|...|         :...:..:.:|.|||||.| |:.||..:||.|.:||:|.|.|||.:
  Rat   273 ERRRLLSSQGVDEFLESKTKSKSKTLDFIDVLLLAKDEHGKELSDEDIRAEADTFMFGGHDTTAS 337

  Fly   301 AMSFVLYALAKFPETQTRLRKELQDVALD---ETTDLDALNGLPYLEALIKEVLRLYTIVPTTGR 362
            |:|::||.||..||.|.|.|:|:.::..|   |..:.|.|..||:|...|||.|||:.......|
  Rat   338 ALSWILYNLASHPEYQERCRQEVWELLRDREPEEIEWDDLAQLPFLTMCIKESLRLHPPAVDLLR 402

  Fly   363 QTTQSTEI-GGRTYCAGVTLWINMYGLAHDKEYYPDPYAFKPERWLPEDGAVAPPAFSYIPFSGG 426
            :.||...: .||....|....|:::|:.|:...:|||..:.|.|:.||:.....| .|:||||.|
  Rat   403 RCTQDIVLPDGRVIPKGNICVISIFGIHHNPSVWPDPEVYDPFRFDPENRQKRSP-LSFIPFSAG 466

  Fly   427 PHVCIGRRYSLLLMKLLTARLVREFQMELSPEQAPLRLEAQMVLKAQQGI 476
            |..|||:.:::..:|:.....:..|:  ..|:....|.:.:::|:|:.|:
  Rat   467 PRNCIGQTFAMNEVKVAVGLTLLRFR--FLPDDKEPRRKPELILRAEGGL 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp311a1	NP_572780.3	p450	30..480	CDD:278495	147/469 (31%)
Cyp4f37	XP_038935973.1	CYP4F	74..517	CDD:410772	141/446 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000