Protein Alignment Cyp311a1 and CYP3A43

DIOPT Version :9

• Sequence 1: NP_572780.3
• Gene: Cyp311a1 / 32170
• FlyBaseID: FBgn0030367
• Length: 483
• Species: Drosophila melanogaster
• Sequence 2: NP_073731.1
• Gene: CYP3A43 / 64816
• HGNCID: 17450
• Length: 504
• Species: Homo sapiens
• Alignment Length: 503
• Identity: 127/503 - (25%)
• Similarity: 216/503 - (42%)
• Gaps: 64/503 - (12%)

  Fly    14 WILVRKWTLL-------------RLGSSLPGPWAFPLLGNAQMVGKLRPEYIFLVFTELRDRFGA 65
            |:||....:|             :||  :|||...|.||.  ::..||..:.|  ..|..:::|
Human    12 WVLVATSLVLLYIYGTHSHKLFKKLG--IPGPTPLPFLGT--ILFYLRGLWNF--DRECNEKYG- 69

  Fly    66 TYRLRLGPQLWVFLHSAEETRQALHDPTLRKA-------DTFMQLEPL-----IGNGLLISHGAH 118
                    ::| .|:..::....:.||.:.|.       ..|....||     :.:.|..:....
Human    70 --------EMW-GLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSFAEDEE 125

  Fly   119 WTRQRRLLTPAFQPQLLRSFAPAIGGHVERLVG--RLGATRGAFLEVTEPLFACLLDAIVDTSMG 181
            |.|.|.||:|||.....:...|.|....:.||.  |..|.....:.:.:...|..:|.|..|..|
Human   126 WKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFG 190

  Fly   182 AQLDTQSVDHSPIIQAFHLSSKLLFKRMINPLLSSDWIFQ-RTQLWRDLDEQL----------QV 235
            ..||:.:....|.::..   .|||....::|.|....:|. .|.::..|:..|          ..
Human   191 VNLDSLNNPQDPFLKNM---KKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKDVTHFLKNS 252

  Fly   236 IHSQMESVIEKRAKELLDMGEPAGRAHNLLDTLLLAKFEGQSLSRREIRDEINTFVFAGVDTTTA 300
            |....||.::.:.|..:|..:....:.|..:|.     ..::||..|:..:....:||..|||:.
Human   253 IERMKESRLKDKQKHRVDFFQQMIDSQNSKETK-----SHKALSDLELVAQSIIIIFAAYDTTST 312

  Fly   301 AMSFVLYALAKFPETQTRLRKELQDVALDET-TDLDALNGLPYLEALIKEVLRLYTIVPTTGRQT 364
            .:.|::|.||..|:.|.:|::|:..|..::. ...|||..:.||:.::.|.|||:.:|....|..
Human   313 TLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVC 377

  Fly   365 TQSTEIGGRTYCAGVTLWINMYGLAHDKEYYPDPYAFKPERWLPEDGAVAPPAFSYIPFSGGPHV 429
            .:..||.|.....|:.:.:.:|.|.||.:|:.:|..|.||....:....:...:.||||..||..
Human   378 KKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPESRFSKKNKDSIDLYRYIPFGAGPRN 442

  Fly   430 CIGRRYSLLLMKLLTARLVREFQMELSPE-QAPLRLEAQMVLKAQQGI 476
            |||.|::|..:||...|.::.|..:...| |.||:|:...:|:.::.|
Human   443 CIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLPILQPEKPI 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp311a1	NP_572780.3	p450	30..480	CDD:278495	121/474 (26%)
CYP3A43	NP_073731.1	p450	39..494	CDD:278495	121/474 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910