DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp311a1 and Cyp4f14

DIOPT Version :9

Sequence 1:	NP_572780.3	Gene:	Cyp311a1 / 32170	FlyBaseID:	FBgn0030367	Length:	483	Species:	Drosophila melanogaster
Sequence 2:	NP_001191262.1	Gene:	Cyp4f14 / 64385	MGIID:	1927669	Length:	524	Species:	Mus musculus

Alignment Length:	510	Identity:	152/510 - (29%)
Similarity:	250/510 - (49%)	Gaps:	53/510 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 WPLLLITLTIWILVRKWTLLRLGSS---------LPGP----WAFPLLGNAQMVGKLRP-EYIFL 54
            |..||:....|||.|  .|:::.::         .|.|    |   |:|:   ||.:.| |....
Mouse    19 WKTLLLLGASWILAR--ILIQIYAAYRNYRHLHGFPQPPKRNW---LMGH---VGMVTPTEQGLK 75

  Fly    55 VFTELRDRFGATYRLRLGPQLWVF-LHSAEETRQALHDP---TLRKADTFMQLEPLIGNGLLISH 115
            ..|.|...:...:.:.:||.:.|. |..::..|..|:..   .|:....:..|:|.:|:|||:|.
Mouse    76 ELTRLVGTYPQGFLMWIGPMVPVITLCHSDIVRSILNASAAVALKDVIFYSILKPWLGDGLLVSA 140

  Fly   116 GAHWTRQRRLLTPAFQPQLLRSFAPAIGGHV-------ERLVGRLGATRGAFLEVTEPLFACLLD 173
            |..|:|.||:|||||...:|:.:........       :||:.. |:.|   |::.|.:....||
Mouse   141 GDKWSRHRRMLTPAFHFNILKPYVKIFNDSTNIMHAKWQRLISD-GSAR---LDMFEHVSLMTLD 201

  Fly   174 AIVDTSMGAQLDTQSVDHSPIIQAFHLSSKLLFKRMINPLLSSDWIFQRTQLWRDLDEQLQVIHS 238
            ::.........:.|......|.....||: |:.||...||:..|.::..|.......:...|:|.
Mouse   202 SLQKCVFSFDSNCQEKSSEYIAAILELSA-LVAKRHQQPLMFMDLLYNLTPDGMRFRKACNVVHE 265

  Fly   239 QMESVIEKRAKELLDMG-------EPAGRAHNLLDTLLLAKFE-GQSLSRREIRDEINTFVFAGV 295
            ..::||.:|.:.|.|.|       :...:..:.:|.|||:|.| |:.||..:||.|.:||:|.|.
Mouse   266 FTDAVIRERHRTLPDQGLDDFLKSKAKSKTLDFIDVLLLSKDEDGKELSDEDIRAEADTFMFEGH 330

  Fly   296 DTTTAAMSFVLYALAKFPETQTRLRKELQDVAL---DETTDLDALNGLPYLEALIKEVLRLYTIV 357
            |||.:.:|::||.||:.||.|.|.|:|:|::..   .|..:.|.|..||:|...|||.|||:..|
Mouse   331 DTTASGLSWILYNLARHPEYQERCRQEVQELLRGREPEEIEWDDLAQLPFLTMCIKESLRLHPPV 395

  Fly   358 PTTGRQTTQSTEI-GGRTYCAGVTLWINMYGLAHDKEYYPDPYAFKPERWLPEDGAVAPPAFSYI 421
            ....|..||...: .|||...|:...|:::|:.|:...:|||..:.|.|:.||:...:.| .::|
Mouse   396 TVISRCCTQDILLPDGRTIPKGIICLISIFGIHHNPSVWPDPEVYDPFRFDPENIKDSSP-LAFI 459

  Fly   422 PFSGGPHVCIGRRYSLLLMKLLTARLVREFQMELSPEQAPLRLEAQMVLKAQQGI 476
            |||.||..|||:.:::..||:..|..:..|:  |.|:....|.:.:::|:|:.|:
Mouse   460 PFSAGPRNCIGQTFAMSEMKVALALTLLRFR--LLPDDKEPRRQPELILRAEGGL 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp311a1	NP_572780.3	p450	30..480	CDD:278495	144/475 (30%)
Cyp4f14	NP_001191262.1	p450	52..511	CDD:365848	143/472 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.810