DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp311a1 and cyp4v8

DIOPT Version :9

Sequence 1:	NP_572780.3	Gene:	Cyp311a1 / 32170	FlyBaseID:	FBgn0030367	Length:	483	Species:	Drosophila melanogaster
Sequence 2:	NP_001071070.1	Gene:	cyp4v8 / 558851	ZFINID:	ZDB-GENE-061103-601	Length:	513	Species:	Danio rerio

Alignment Length:	489	Identity:	156/489 - (31%)
Similarity:	249/489 - (50%)	Gaps:	50/489 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 VRKWTLLRLGSSLPGPW-AFPLLGNA-----------QMVGKLRPEYIFLVFTELRDRFGATYRL 69
            :.||..|:   .:||.. .||.:|||           |:||         ..||.::  ....::
Zfish    34 LHKWKELK---PIPGIGNTFPFIGNALQFKSNGDFFLQLVG---------YTTEFQN--SPLLKI 84

  Fly    70 RLGPQLWVFLHSAEETRQALHDPT-LRKADTFMQLEPLIGNGLLISHGAHWTRQRRLLTPAFQPQ 133
            .:||..::.|..||.....|::|. :.||..:..|.|.:|.|||.|.|..|.|:|::|||.|...
Zfish    85 WIGPIPFLILFHAETVETVLNNPVHIDKAYAYQFLHPWLGTGLLTSTGDKWRRRRKMLTPTFHFS 149

  Fly   134 LLRSFAPAIGGHVERLVGRLGATRG-----AFLEVTEPLFACLLDAIVDTSMGAQLDTQSVDHSP 193
            :|..|...:....|.|:.:|....|     .|..:|    .|.||.|.:|:||.::..||...|.
Zfish   150 ILTEFLEVMNEQAEVLIEKLEKQAGKGPFNCFSHIT----LCALDIICETAMGKRIYAQSNYDSE 210

  Fly   194 IIQAFHLSSKLLFKRMINPLLSSDWIFQRTQLWRDLDEQLQVIHSQMESVIEKRAKEL------- 251
            .::..:..|.::.:|...|....|:::......|:.:..|:::||..||||.:||:.|
Zfish   211 YVRTVYRMSDIITRRQRMPWYWPDFVYNYVGEGREHNRSLKILHSFTESVINERAEYLSYVESDS 275

  Fly   252 -LDMGEPAGRAHNLLDTLLLAKFE-GQSLSRREIRDEINTFVFAGVDTTTAAMSFVLYALAKFPE 314
             .|.|....||  .||.||..|.| |:.|:.::|::|::||:|.|.|||.|||::.::.|...||
Zfish   276 ESDQGMRKRRA--FLDMLLKTKDEDGKMLTHKDIQEEVDTFMFEGHDTTAAAMNWAIHLLGSHPE 338

  Fly   315 TQTRLRKELQDV--ALDETTDLDALNGLPYLEALIKEVLRLYTIVPTTGRQTTQSTEIGGRTYCA 377
            .|.:.::||.:|  ..:...:.:.|..|.|||.:|||.|||:..||...|.....|:|.|.....
Zfish   339 VQRKAQQELFEVFGESERPVNTEDLKKLRYLECVIKESLRLFPSVPFFARTICDDTQINGFKVPK 403

  Fly   378 GVTLWINMYGLAHDKEYYPDPYAFKPERWLPEDGAVAPPAFSYIPFSGGPHVCIGRRYSLLLMKL 442
            |..:.:..|.|..|..::|||..|:|||:|||: .|....::|||||.|...|||:|::::..|:
Zfish   404 GTNIVVITYALHRDPRFFPDPEEFRPERFLPEN-CVGRHPYAYIPFSAGLRNCIGQRFAIMEEKV 467

  Fly   443 LTARLVREFQMELSPEQAPLRLEAQMVLKAQQGI 476
            :.|.::|.|.:....::..||...::||:.:|||
Zfish   468 ILAYILRYFNIVACQKREELRPLGELVLRPEQGI 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp311a1	NP_572780.3	p450	30..480	CDD:278495	153/476 (32%)
cyp4v8	NP_001071070.1	p450	44..501	CDD:278495	151/474 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.910