DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp311a1 and cyp3a65

DIOPT Version :9

Sequence 1:	NP_572780.3	Gene:	Cyp311a1 / 32170	FlyBaseID:	FBgn0030367	Length:	483	Species:	Drosophila melanogaster
Sequence 2:	NP_001032515.1	Gene:	cyp3a65 / 553969	ZFINID:	ZDB-GENE-050604-1	Length:	517	Species:	Danio rerio

Alignment Length:	525	Identity:	131/525 - (24%)
Similarity:	220/525 - (41%)	Gaps:	85/525 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 WPLLLITLTIWILVRKWT---LLRLGSSLPGPWAFPLLGNAQMVGKLRPEYIFLVF-TELRDRFG 64
            |.||.....:.::...|.   ..:||  :|||.|.|..|.     .||.:..|.|| .:..:::|
Zfish     8 WTLLAFLAALLVIYGSWPHRYFKKLG--IPGPKAIPFFGT-----MLRYKDGFHVFDMDCFEKYG 65

  Fly    65 ATYRLRLGPQLWVFLHSAEETRQALHDPTLRKADTFMQLEPLIG-------NGLL-----ISHGA 117
                     ::| .::...:....:.|.|:.|.....:...|..       ||.|     |:...
Zfish    66 ---------RIW-GIYDGRQPVLCIMDQTIIKTVLIKECYSLFTNRRNFRLNGALYDAVSIAEDD 120

  Fly   118 HWTRQRRLLTPAFQPQLLRSFAPAIGGHVERLVGRLGAT--RGAFLEVTEPLFACLLDAIVDTSM 180
            .|.|.|.:|:|:|....|:.....:..|...||..:|.|  ||...::.|...|..:|.:..|:.
Zfish   121 DWRRIRSVLSPSFTSGRLKEMFGIMKKHSHILVDSMGKTAKRGESADIKEFFGAYSMDVVTSTAF 185

  Fly   181 GAQLDTQSVDHSPIIQAFHLSSKLLFKRMINPLL--------------SSDWIFQRTQLWRDLDE 231
            ...:|:.:....|.:...   .|:|...::|||.              ..|:....|.:......
Zfish   186 SVDIDSLNNPKDPFVTNI---KKMLKFDLLNPLFLLIAFFPFMAPVLEKMDFALFPTSVTDFFYA 247

  Fly   232 QLQVIHSQME--SVIEKRAKELLD-----MGEPAGRAHNLLDTLLLAKFEGQ----SLSRREIRD 285
            .||.|.|..:  :|.:...|:.:|     :....|..|         |.:|:    .||..||..
Zfish   248 ALQKIKSDRDTKTVAKDNTKKRVDFLQLMVDSQTGVKH---------KSDGEHTEKGLSDHEILS 303

  Fly   286 EINTFVFAGVDTTTAAMSFVLYALAKFPETQTRLRKELQDVALDET------TDLDALNGLPYLE 344
            :...|:|||.:|:::.:||:.|.||..|||..:|::|     :|||      .|.:.|..:.||:
Zfish   304 QSMIFIFAGYETSSSTLSFLFYNLATNPETMKKLQEE-----IDETFPNQAPVDYETLMSMDYLD 363

  Fly   345 ALIKEVLRLYTIVPTTGRQTTQSTEIGGRTYCAGVTLWINMYGLAHDKEYYPDPYAFKPERWLPE 409
            |.:.|.|||:.:.....|...::.||.|......:.:.:..|.|..|.:|:.:|.:|||||:...
Zfish   364 AALSESLRLFPVAARLERVCKKTVEINGLLIPKDLVVMVPTYALHRDPDYWSEPESFKPERFTKG 428

  Fly   410 DGAVAPPAFSYIPFSGGPHVCIGRRYSLLLMKLLTARLVREFQMELSPE-QAPLRLEAQMVLKAQ 473
            :.....| :.|:||..||..|||.|::.:.|||....:::.|.:.:..| |.||.|....:|..:
Zfish   429 NKESIDP-YMYMPFGLGPRNCIGMRFAQVTMKLAIVEILQRFDVSVCDETQVPLELGFNGLLSPK 492

  Fly   474 QGINV 478
            ..|.:
Zfish   493 DPIKL 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp311a1	NP_572780.3	p450	30..480	CDD:278495	125/496 (25%)
cyp3a65	NP_001032515.1	p450	35..499	CDD:278495	125/496 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910