DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp311a1 and Cyp4a1

DIOPT Version :9

Sequence 1:	NP_572780.3	Gene:	Cyp311a1 / 32170	FlyBaseID:	FBgn0030367	Length:	483	Species:	Drosophila melanogaster
Sequence 2:	NP_787031.1	Gene:	Cyp4a1 / 50549	RGDID:	68945	Length:	509	Species:	Rattus norvegicus

Alignment Length:	503	Identity:	153/503 - (30%)
Similarity:	255/503 - (50%)	Gaps:	49/503 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLLITLTIWILVRKWTLLRLGSSLPGP---WAFPLLGNAQMVGKLRPEYIFLVFTELRDRFGATY 67
            |||:....:.|.|:| ||:.....|.|   |.|   |:.|..|....:.|..........|.
  Rat    29 LLLVKAVQFYLQRQW-LLKAFQQFPSPPFHWFF---GHKQFQGDKELQQIMTCVENFPSAFP--- 86

  Fly    68 RLRLGPQLWVFLHSAEETRQAL--HDPTLRKAD-TFMQLEPLIGNGLLISHGAHWTRQRRLLTPA 129
            |...|.:.::.::..:..:..|  .||   ||: .:..|.|.||.|||:.:|..|.:.||:||||
  Rat    87 RWFWGSKAYLIVYDPDYMKVILGRSDP---KANGVYRLLAPWIGYGLLLLNGQPWFQHRRMLTPA 148

  Fly   130 FQPQLLRSFAPAIGGHV-------ERLVGRLGATRGAFLEVTEPLFACLLDAIVDTSM----GAQ 183
            |...:|:.:...:...:       |:|.|     :.:.:|:.:.:....||.::..:.    ..|
  Rat   149 FHYDILKPYVKNMADSIRLMLDKWEQLAG-----QDSSIEIFQHISLMTLDTVMKCAFSHNGSVQ 208

  Fly   184 LDTQSVDHSPIIQAFHLSSKLLFKRMINPLLSSDWIFQRTQLWRDLDEQLQVIHSQMESVIEKRA 248
            :|.   ::...|||....:.|...|:.|....:|.|:..:......:...|:.|...:.||:.|.
  Rat   209 VDG---NYKSYIQAIGNLNDLFHSRVRNIFHQNDTIYNFSSNGHLFNRACQLAHDHTDGVIKLRK 270

  Fly   249 KELLDMGE----PAGRAHNLLDTLLLAKFE-GQSLSRREIRDEINTFVFAGVDTTTAAMSFVLYA 308
            .:|.:.||    ...|..:.||.||||:.| |.|||.:::|.|::||:|.|.|||.:.:|::.||
  Rat   271 DQLQNAGELEKVKKKRRLDFLDILLLARMENGDSLSDKDLRAEVDTFMFEGHDTTASGVSWIFYA 335

  Fly   309 LAKFPETQTRLRKELQDVALD-ETTDLDALNGLPYLEALIKEVLRLYTIVPTTGRQ-TTQSTEIG 371
            ||..||.|.|.|:|:|.|..| .:...|.|:.:||....|||.||||..||...|: :|..|...
  Rat   336 LATHPEHQQRCREEVQSVLGDGSSITWDHLDQIPYTTMCIKEALRLYPPVPGIVRELSTSVTFPD 400

  Fly   372 GRTYCAGVTLWINMYGLAHDKEYYPDPYAFKPERWLPEDGAVAP-PAFSYIPFSGGPHVCIGRRY 435
            ||:...|:.:.:::|||.|:.:.:|:|..|.|.|:.|:    :| .:.|::|||||...|||:::
  Rat   401 GRSLPKGIQVTLSIYGLHHNPKVWPNPEVFDPSRFAPD----SPRHSHSFLPFSGGARNCIGKQF 461

  Fly   436 SLLLMKLLTARLVREFQMELSPEQAPLRLEAQMVLKAQQGINVSFLKQ 483
            ::..||::.|..:..|::...|.:.|:.| .::|||::.||.: :||:
  Rat   462 AMSEMKVIVALTLLRFELLPDPTKVPIPL-PRLVLKSKNGIYL-YLKK 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp311a1	NP_572780.3	p450	30..480	CDD:278495	143/474 (30%)
Cyp4a1	NP_787031.1	p450	52..503	CDD:278495	143/472 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910