DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp311a1 and Cyp4f40

DIOPT Version :9

Sequence 1:	NP_572780.3	Gene:	Cyp311a1 / 32170	FlyBaseID:	FBgn0030367	Length:	483	Species:	Drosophila melanogaster
Sequence 2:	XP_038935701.1	Gene:	Cyp4f40 / 503122	RGDID:	1559596	Length:	530	Species:	Rattus norvegicus

Alignment Length:	515	Identity:	147/515 - (28%)
Similarity:	234/515 - (45%)	Gaps:	56/515 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 WPLLLITLTIWILVRKWTLL--------RLGSSLPGP----WAFPLLGNAQMVGKLRP--EYIFL 54
            |.||.:....|.|.|..|.:        || ...|.|    |.:..||       :.|  |....
  Rat    19 WLLLSLVGVSWFLTRCLTQIYTLYAKCQRL-CGFPQPPKRSWFWGHLG-------MSPPTEEGMK 75

  Fly    55 VFTELRDRFGATYRLRLGPQL-WVFLHSAEETRQALHDPTL---RKADTFMQLEPLIGNGLLISH 115
            ..|||...:...:...|||.: .:.|...:..|..|.....   :....:..|:|.:|:|||:|.
  Rat    76 QMTELVATYPQGFMTWLGPIVPLITLCHPDIIRSVLSASAAVAPKDGIFYSFLKPWLGDGLLVSA 140

  Fly   116 GAHWTRQRRLLTPAFQPQLLRSFAPAIGG-----HVERLVGRLGATRGAFLEVTEPLFACLLDAI 175
            ...|:|.|.:|||||...:|:.:......     |.:.|  ||.:...|.|::.|.:....||.:
  Rat   141 SDKWSRHRSMLTPAFHFNILKPYVKIFNDSTNIMHAKWL--RLASGGSAHLDMFENISLMTLDTL 203

  Fly   176 VDTSMGAQLDTQSVDHSPIIQAFHLSSKLLFKRMINPLLSSDWIFQRTQLWRDLDEQLQVIHSQM 240
            .........:.|......|.....||: |:.||....||..|.:::.|...|...:...::|...
  Rat   204 QKCVFSFNSNCQEKPSEYIAAILELSA-LVVKRNEQLLLHMDLLYRLTPDGRRFYKACHLVHDFT 267

  Fly   241 ESVIEKRAKELLDMG-------EPAGRAHNLLDTLLLAKFE-GQSLSRREIRDEINTFVFAGVDT 297
            .:||::|.:.|...|       :...:..:.:|.|||:|.| |:.||..:||.|.:||:|.|.||
  Rat   268 YAVIQERRRTLPKHGGDDVIKAKAKSKTLDFIDVLLLSKDEDGKELSDEDIRAEADTFMFEGHDT 332

  Fly   298 TTAAMSFVLYALAKFPETQTRLRKELQDVALDETTD----------LDALNGLPYLEALIKEVLR 352
            |.:.:|::||.|||.||.|.|.|:|:|::..|..::          .|.|..||:|...|||.||
  Rat   333 TASGLSWILYNLAKHPEYQERCRQEVQELLRDRDSEEIECSCGVLLRDDLAQLPFLTMCIKESLR 397

  Fly   353 LYTIVPTTGRQTTQSTEI-GGRTYCAGVTLWINMYGLAHDKEYYPDPYAFKPERWLPEDGAVAPP 416
            |:..|....|..||...: .||....|:...||::...|:...:.||..:.|.|:.||:.....|
  Rat   398 LHPPVTMVSRCCTQDISLPDGRVIPKGIICIINIFATHHNPTVWQDPEVYDPFRFDPENIQARSP 462

  Fly   417 AFSYIPFSGGPHVCIGRRYSLLLMKLLTARLVREFQMELSPEQAPLRLEAQMVLKAQQGI 476
             .::||||.||..|||:.:::..||:..|..:..|:  :.|:....|.:.:::|:|:.|:
  Rat   463 -LAFIPFSAGPRNCIGQTFAMNEMKVAVALTLLRFR--VLPDDKEPRRKPELILRAEDGL 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp311a1	NP_572780.3	p450	30..480	CDD:278495	138/481 (29%)
Cyp4f40	XP_038935701.1	CYP4F	74..522	CDD:410772	131/452 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.810