DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp311a1 and Cyp4c3

DIOPT Version :9

Sequence 1:	NP_572780.3	Gene:	Cyp311a1 / 32170	FlyBaseID:	FBgn0030367	Length:	483	Species:	Drosophila melanogaster
Sequence 2:	NP_524598.1	Gene:	Cyp4c3 / 43663	FlyBaseID:	FBgn0015032	Length:	535	Species:	Drosophila melanogaster

Alignment Length:	510	Identity:	154/510 - (30%)
Similarity:	246/510 - (48%)	Gaps:	51/510 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LLITLTIWILV---RKWTLLRLGSSLPGPWAFPLLGNAQMVGKLRPEYIFLVFTELRDRFGATYR 68
            ||.::.|:::|   |:..|::....:|||.|.|.||||..:.        :...||.:|.....:
  Fly    33 LLGSILIFLVVYNKRRSRLVKYIEKIPGPAAMPFLGNAIEMN--------VDHDELFNRVIGMQK 89

  Fly    69 L---RLG-PQLW------VFLHSAEETRQALHDPT-LRKADTFMQLEPLIGNGLLISHGAHWTRQ 122
            |   |:| .::|      |.|...|.....|:... :.|:..:..|.|.:|.|||.|....|..:
  Fly    90 LWGTRIGINRVWQGTAPRVLLFEPETVEPILNSQKFVNKSHDYDYLHPWLGEGLLTSTDRKWHSR 154

  Fly   123 RRLLTPAFQPQLLRSFAPAIGGHVERLVGRLGATRGA-----FLEVTEPLFACLLDAIVDTSMGA 182
            |::|||||..::|..|..........|..:|....|:     |..||    .|.||.:.:|:||.
  Fly   155 RKILTPAFHFKILDDFIDVFNEQSAVLARKLAVEVGSEAFNLFPYVT----LCTLDIVCETAMGR 215

  Fly   183 QLDTQSVDHSPIIQAFHLSSKLLFKRMINPLLSSDWIFQRTQLWRDLDEQLQVIHSQMESVIEKR 247
            ::..||...|..::|.:....::..|.....|.||:||..|..::.....:..:|.....||.:|
  Fly   216 RIYAQSNSESEYVKAVYGIGSIVQSRQAKIWLQSDFIFSLTAEYKLHQSYINTLHGFSNMVIRER 280

  Fly   248 AKELL--------------DMGEPAGRAHNL--LDTLLLAKFEGQSLSRREIRDEINTFVFAGVD 296
            ..||.              |..:..|:...|  ||.|:.|..||..||..:||:|::||:|.|.|
  Fly   281 KAELAILQENNNNNNNNAPDAYDDVGKKKRLAFLDLLIDASKEGTVLSNEDIREEVDTFMFEGHD 345

  Fly   297 TTTAAMSFVLYALAKFPETQTRLRKELQDVALDE---TTDLDALNGLPYLEALIKEVLRLYTIVP 358
            ||:||:|:.|:.|...||.|.|:.:||..:..|:   ...:..|..:.|||..||:.|||:..||
  Fly   346 TTSAAISWTLFLLGCHPEYQERVVEELDSIFGDDKETPATMKNLMDMRYLECCIKDSLRLFPSVP 410

  Fly   359 TTGRQTTQSTEIGGRTYCAGVTLWINMYGLAHDKEYYPDPYAFKPERWLPEDGAVAPPAFSYIPF 423
            ...|...:...|||:...||....|..|.|..:...:|.|..|.|:.:|||:.|...| |:||||
  Fly   411 MMARMVGEDVNIGGKIVPAGTQAIIMTYALHRNPRVFPKPEQFNPDNFLPENCAGRHP-FAYIPF 474

  Fly   424 SGGPHVCIGRRYSLLLMKLLTARLVREFQMELSPEQAPLRLEAQMVLKAQQGINV 478
            |.||..|||:::::|..|.:.:.::|::::|....:..|.|..:::|:.:.|:.|
  Fly   475 SAGPRNCIGQKFAILEEKAVISTVLRKYKIEAVDRREDLTLLGELILRPKDGLRV 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp311a1	NP_572780.3	p450	30..480	CDD:278495	148/484 (31%)
Cyp4c3	NP_524598.1	p450	59..531	CDD:278495	148/484 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	8	7.960