DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp311a1 and Cyp313a1

DIOPT Version :9

Sequence 1:	NP_572780.3	Gene:	Cyp311a1 / 32170	FlyBaseID:	FBgn0030367	Length:	483	Species:	Drosophila melanogaster
Sequence 2:	NP_650368.1	Gene:	Cyp313a1 / 41759	FlyBaseID:	FBgn0038236	Length:	492	Species:	Drosophila melanogaster

Alignment Length:	495	Identity:	116/495 - (23%)
Similarity:	210/495 - (42%)	Gaps:	51/495 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLLITLTIWILVRKWTLLR---LGSSLPGPWAFPLLGNA-QMVGKLRPEYIFLVFTELRDRFGAT 66
            ||.:....||.. .|:..|   |...:|||...|:||:: :.:...:.:..|.  |:..:::|:|
  Fly     7 LLAVGALFWIYF-LWSRRRLYFLMLKIPGPIGLPILGSSLENIITYKRKLSFR--TKYLNKYGST 68

  Fly    67 YRLRLGPQLWVFLHSAEETRQALHDPTLRKADTFM--QLEPLIGNGLLISHGAHWTRQRRLLTPA 129
            ....:||..::.....:........|........:  .:...:|||||.....||..:|:...|:
  Fly    69 ILTWMGPVPFIVTRDPKVVEDIFSSPDCHNKSQHIVNAITSCMGNGLLGKQDPHWLDRRKHFNPS 133

  Fly   130 FQPQLLRSFAPAIGGHVERLVGRLG--ATRGAFLEVTEPLFACLLDAIVDTSMGAQL-DTQSVDH 191
            |:..||.||........:.|:..|.  ..:|. ::|...:..........|:||::: ..:...:
  Fly   134 FKQDLLLSFFHIFDAETKVLMNLLDTYVDKGE-IDVVPEMLRWSFKIAAQTTMGSEVKHDEHFKN 197

  Fly   192 SPIIQAF-----HLSSKLLF----KRMINPLLSSDWI----FQRTQLWRDLDEQLQVIHSQMESV 243
            ..::::|     |.:..:|.    .|||:.:...|.:    |.|             |...:::|
  Fly   198 GSLVESFESLISHSTLNILMPLVQNRMISKICGYDKLRADNFSR-------------IQKMLDNV 249

  Fly   244 IEKRAKELLDM-GEPAGRAHNLLDTLLLAKFEGQSLSRREIRDEINTFVFAGVDTTTAAMSFVLY 307
            :.|:...|... .:|..   |::....:..:....::..:::.|....:.||.||:...:...|:
  Fly   250 VNKKVNPLPKTDSDPES---NIVINRAMELYRKGDITYMDVKSECCIMIAAGYDTSALTVYHALF 311

  Fly   308 ALAKFPETQTRLRKELQDVALDE----TTDLDALNGLPYLEALIKEVLRLYTIVPTTGRQTTQST 368
            .||..||.|..:.:||..|..|.    .|..| :..|.|||.:|||.|||...:|.|.|:|....
  Fly   312 LLANHPEHQEAVFEELNGVFPDAGHFGITYPD-MQKLDYLERVIKETLRLIPAIPITARETKNDV 375

  Fly   369 EI-GGRTYCAGVTLWINMYGLAHDKEYY-PDPYAFKPERWLPEDGAVAPPAFSYIPFSGGPHVCI 431
            .: .|.....||.:.|:|:....:.|.: ||...|.|:.:|.|:.....| ::||||:.|...||
  Fly   376 RLSNGVLIPKGVVIGIDMFHTHRNPEVWGPDADNFNPDNFLAENMEQKHP-YAYIPFARGKRNCI 439

  Fly   432 GRRYSLLLMKLLTARLVREFQMELSPEQAPLRLEAQMVLK 471
            |.:|:::..|....|::|.:::..|.....|.....|.:|
  Fly   440 GSKYAMMSSKFALCRILRNYKISTSTLYKDLVYVDNMTMK 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp311a1	NP_572780.3	p450	30..480	CDD:278495	109/468 (23%)
Cyp313a1	NP_650368.1	p450	33..463	CDD:299894	105/450 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45442789
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	1	0.950	-	0	Normalized mean entropy	S4824
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	7	6.740