DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp311a1 and Cyp313a4

DIOPT Version :9

Sequence 1:	NP_572780.3	Gene:	Cyp311a1 / 32170	FlyBaseID:	FBgn0030367	Length:	483	Species:	Drosophila melanogaster
Sequence 2:	NP_650224.3	Gene:	Cyp313a4 / 41563	FlyBaseID:	FBgn0038076	Length:	494	Species:	Drosophila melanogaster

Alignment Length:	494	Identity:	131/494 - (26%)
Similarity:	228/494 - (46%)	Gaps:	29/494 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LWPLLLITLTIWIL--VRKWTLLRLGSSLPGPWAFPLLGNAQMVGKLRPEYIFLVFTELRDRFGA 65
            ||..||..|.|:.|  .|::.||.|  .:|||..:|:||.|..:  :|.|.|...|....|:.|.
  Fly     6 LWCGLLFLLWIYFLWSRRRFYLLTL--KIPGPLGYPILGMAHWL--MRREDILNAFGCFLDKHGP 66

  Fly    66 TYRLRLGPQLWVFLHSAEETRQALHDP-TLRKADTFMQLEPLIGNGLLISHGAHWTRQRRLLTPA 129
            |....|||..::.:...:..:.....| .:.|...:..::...|.||.......|:..|:||.||
  Fly    67 TIFSWLGPIPFMIVSDPQVVQDIFTSPHCVNKGIIYKAVDDGAGVGLFSLKDPRWSIHRKLLNPA 131

  Fly   130 FQPQLLRSFAPAIGGHVERLVGRLGATRGAFLEVTEPLF-ACLLDAIVDTSMGAQL-DTQSVDHS 192
            |..::|.||.|........|:.:|...:....:...||. :..|.....|:||:.: |.:|...:
  Fly   132 FGHKVLLSFLPIFNRETALLLDQLEPLQDDGEKDLIPLLQSFTLGIATQTTMGSDVKDEESFRSN 196

  Fly   193 PIIQAFHLSSKLLFKRMINPLLSSDWIFQRTQLWRDLDEQLQVIHSQMESVIEKRAKELLDMGE- 256
            .::..:....:.:.....:|.|:|.:..|.........:....|...:..:||::..| .:||.
  Fly   197 SLLGRYQCILETMTDMCFSPWLNSRFCRQLAGKESHYYQAKTEIRQFIRKIIERKLAE-DEMGAL 260

  Fly   257 PAGRAH--NLLDTLLLAKFEGQSLSRREIRDEINTFVFAGVDTTTAAMSFVLYALAKFPETQTRL 319
            |:.:::  ||...|:.........:.:.:.||.|..||...:||..|:.:.|..||.|||.|.|.
  Fly   261 PSIQSNDKNLFLNLVTDLMRRGVFTLKNVEDESNIIVFGAFETTANAVYYTLMLLAMFPEYQERA 325

  Fly   320 RKELQDVALDETTDLDA----LNGLPYLEALIKEVLRLYTIVPTTGRQTTQSTEI-GGRTYCAGV 379
            .:|::.: ...|.|.|.    ...:.||:.::.|.:|:...||...|||:|..:: .|.....||
  Fly   326 FEEIKTI-FPNTGDFDVSYADTQQMVYLDLILNESMRVIPPVPVVSRQTSQDLKLSNGIVVPKGV 389

  Fly   380 TLWINMYGLAHDKEYY-PDPYAFKPERWLPEDGAVAPPAFSYIPFSGGPHVCIGRRYSLLLMKLL 443
            .:.|::|.:...|:.: ||...|.|:.:||.:.....| ::||||:.|...|||.||:|:..|:.
  Fly   390 QIAIDIYHMHRSKKIWGPDAETFNPDHFLPHNIQDKHP-YAYIPFTKGIRNCIGWRYALISAKVT 453

  Fly   444 TARLVREFQMELS--------PEQAPLRLEAQMVLKAQQ 474
            .|:|:|.::.:.|        .|...::|::..:|:.|:
  Fly   454 LAKLLRNYRFKTSFPFENLYFVEDITMKLKSVPLLELQK 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp311a1	NP_572780.3	p450	30..480	CDD:278495	120/465 (26%)
Cyp313a4	NP_650224.3	p450	33..465	CDD:299894	115/436 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45442791
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.790