DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp311a1 and CYP4F3

DIOPT Version :9

Sequence 1:	NP_572780.3	Gene:	Cyp311a1 / 32170	FlyBaseID:	FBgn0030367	Length:	483	Species:	Drosophila melanogaster
Sequence 2:	NP_000887.2	Gene:	CYP4F3 / 4051	HGNCID:	2646	Length:	520	Species:	Homo sapiens

Alignment Length:	520	Identity:	156/520 - (30%)
Similarity:	249/520 - (47%)	Gaps:	60/520 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MALWP-------LLLITLTIWILVR--KWT------LLRLGSSLPGP----WAFPLLGNAQMVGK 46
            :.|||       |||:....|:|.|  .||      ..|| ...|.|    |   .||:   :|.
Human     9 LGLWPMAASPWLLLLLVGASWLLARILAWTYTFYDNCCRL-RCFPQPPKRNW---FLGH---LGL 66

  Fly    47 LRPEYIFLVFTE-LRDRFGATYRLRLGPQLW---VFLHSAEETRQALHDPT--LRKADTFMQ-LE 104
            :......|::|: |...||......:||  |   |.:......:..|..|.  :.|...|.. |:
Human    67 IHSSEEGLLYTQSLACTFGDMCCWWVGP--WHAIVRIFHPTYIKPVLFAPAAIVPKDKVFYSFLK 129

  Fly   105 PLIGNGLLISHGAHWTRQRRLLTPAFQPQLLRSFAPAIGGHVE------RLVGRLGATRGAFLEV 163
            |.:|:|||:|.|..|:|.||:|||||...:|:.:.......|.      :|:...|:.|   |::
Human   130 PWLGDGLLLSAGEKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSAR---LDM 191

  Fly   164 TEPLFACLLDAIVDTSMGAQLDTQSVDHSPIIQAFHLSSKLLFKRMINPLLSSDWIFQRTQLWRD 228
            .|.:....||::...........|......|.....||: |:.||....||..|:::..|...:.
Human   192 FEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSA-LVTKRHQQILLYIDFLYYLTPDGQR 255

  Fly   229 LDEQLQVIHSQMESVIEKRAKELLDMG-------EPAGRAHNLLDTLLLAKFE-GQSLSRREIRD 285
            .....:::|...::||::|.:.|...|       :...:..:.:|.|||:|.| |:.||..:||.
Human   256 FRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRA 320

  Fly   286 EINTFVFAGVDTTTAAMSFVLYALAKFPETQTRLRKELQDVALD---ETTDLDALNGLPYLEALI 347
            |.:||:|.|.|||.:.:|:|||.|||.||.|.|.|:|:|::..|   :..:.|.|..||:|...|
Human   321 EADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCI 385

  Fly   348 KEVLRLYTIVPTTGRQTTQSTEI-GGRTYCAGVTLWINMYGLAHDKEYYPDPYAFKPERWLPEDG 411
            ||.|||:..||...|..||...: .||....|:...|:::|..|:...:|||..:.|.|:.|::.
Human   386 KESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPKNI 450

  Fly   412 AVAPPAFSYIPFSGGPHVCIGRRYSLLLMKLLTARLVREFQMELSPEQAPLRLEAQMVLKAQQGI 476
            ....| .::||||.||..|||:.:::..||::....:..|:  :.|:....|.:.::||:|:.|:
Human   451 KERSP-LAFIPFSAGPRNCIGQAFAMAEMKVVLGLTLLRFR--VLPDHTEPRRKPELVLRAEGGL 512

Fly 477 476
Human 513 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp311a1	NP_572780.3	p450	30..480	CDD:278495	143/476 (30%)
CYP4F3	NP_000887.2	p450	52..515	CDD:365848	143/476 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.810