DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp311a1 and Cyp4aa1

DIOPT Version :9

Sequence 1:	NP_572780.3	Gene:	Cyp311a1 / 32170	FlyBaseID:	FBgn0030367	Length:	483	Species:	Drosophila melanogaster
Sequence 2:	NP_611067.2	Gene:	Cyp4aa1 / 36752	FlyBaseID:	FBgn0034053	Length:	510	Species:	Drosophila melanogaster

Alignment Length:	509	Identity:	141/509 - (27%)
Similarity:	230/509 - (45%)	Gaps:	71/509 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLLITLTIWILVRKW-TLLR---LGSSLPGPWAFPLLGNAQMV----------GKLRPEYIFLVF 56
            ||:|:|:|:...... |.||   |...|.||.:.|.|||..:|          ||        .|
  Fly    21 LLVISLSIYTFYATLNTYLRSVLLSLRLTGPPSLPFLGNCMLVTDKDLMRRCAGK--------AF 77

  Fly    57 TELRDRFGATYRL---------RLGPQ-LWVFLHSAEETRQALHDPTLRKADTFMQLEPLIGNGL 111
                |.:|:..|:         .|.|: |.|.|.|.:.|         .|...:..:...:|:||
  Fly    78 ----DLYGSLVRIWVLLFPFFAVLEPEDLQVILSSKKHT---------NKVFFYRLMHNFLGDGL 129

  Fly   112 LISHGAHWTRQRRLLTPAFQPQLLRSFAPAIGGHVERLVGRLGATR-GAFLEVTEPLFACLLDAI 175
            :.|.|:.|:..|||:.|||...||..|........:.|...|.|.. |..:.:.:.:..|:||.:
  Fly   130 ITSSGSKWSNHRRLIQPAFHHNLLEKFIDTFVDASQSLYENLDAEAVGTEINIAKYVNNCVLDIL 194

  Fly   176 VDTSMGAQL-----DTQSVDHSPIIQAFHLSSKLLFKRMINPLLSSDWIFQRTQLWRDLDEQLQV 235
            .:..:|..:     |...::.||    |.....::..|...|.|..|.|:..|::..|...|.:.
  Fly   195 NEAVLGVPIKKRGQDVAMMEDSP----FRQGKIMMPARFTQPWLLLDGIYHWTKMANDELNQKKR 255

  Fly   236 IHSQMESVIEKRAKELLDMGEPAGRAHNLLDTLLLAKFEGQSLSRREIRDEINTFVFAGVDTTTA 300
            ::.....:|::| :::.:..........|||.::......:..:..:|.:|..||:.||.|:..|
  Fly   256 LNDFTRKMIQRR-RQIQNNNNGNSERKCLLDHMIEISESNRDFTEEDIVNEACTFMLAGQDSVGA 319

  Fly   301 AMSFVLYALAKFPETQTRLRKELQDVALDET-----TDLDALNGLPYLEALIKEVLRLYTIVPTT 360
            |::|.|:.|.:.||.|.|...||..:..|..     |||..:.   |:|..|||.||||..||..
  Fly   320 AVAFTLFLLTQNPECQDRCVLELATIFEDSNRAPTMTDLHEMR---YMEMCIKEALRLYPSVPLI 381

  Fly   361 GRQTTQSTEIGGRTYCAGVTLWINMYG---LAHDKEYYPDPYAFKPERWLPEDGAVAPPAFSYIP 422
            .|:..:...:...|..||..::|..|.   |||   .||||..|:|||:.||:.....| ::::|
  Fly   382 ARKLGEEVRLAKHTLPAGSNVFICPYATHRLAH---IYPDPEKFQPERFSPENSENRHP-YAFLP 442

  Fly   423 FSGGPHVCIGRRYSLLLMKLLTARLVREFQMELSPEQAPLRLEAQMVLKAQQGI 476
            ||.||..|||.|::::.:|.:.:||:|.:|:.....:..:....::.|:|..|:
  Fly   443 FSAGPRYCIGNRFAIMEIKTIVSRLLRSYQLLPVTGKTTIAATFRITLRASGGL 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp311a1	NP_572780.3	p450	30..480	CDD:278495	131/481 (27%)
Cyp4aa1	NP_611067.2	p450	50..475	CDD:278495	128/457 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	102	1.000	Inparanoid score	I1639
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	7	7.060