DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp311a1 and Cyp4e2

DIOPT Version :9

Sequence 1:	NP_572780.3	Gene:	Cyp311a1 / 32170	FlyBaseID:	FBgn0030367	Length:	483	Species:	Drosophila melanogaster
Sequence 2:	NP_001286196.1	Gene:	Cyp4e2 / 35822	FlyBaseID:	FBgn0014469	Length:	526	Species:	Drosophila melanogaster

Alignment Length:	525	Identity:	145/525 - (27%)
Similarity:	250/525 - (47%)	Gaps:	54/525 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LWPLLLITLTIWILVRKWTLL------RLGSSLPGPWAFPLLGNAQMVGKLRPEYIFLVFTELRD 61
            :|.:|.|.|.:.:|:..:..|      |:.:...||...||:|||..:||...|.:..||:....
  Fly     1 MWFVLYIFLALPLLLVAYLELSTFRRRRVLNKFNGPRGLPLMGNAHQMGKNPSEILDTVFSWWHQ 65

  Fly    62 RFGATYRLRLGPQLWVFLHSAEETRQALHDPTL-RKADTFMQLEPLIGNGLLISHGAHWTRQRRL 125
            .....:...:|....|.:.|::.....|...|| .|:|.:....|.:|.|||.|.|:.|.:.|::
  Fly    66 YGKDNFVFWIGTYSNVLVTSSKYLEFILSSQTLITKSDIYQLTHPWLGLGLLTSTGSKWHKHRKM 130

  Fly   126 LTPAFQPQLLRSFAPAIGGHVERLVGRLG--ATRGAFLEVTEPLFACLLDAIVDTSMGAQLDTQS 188
            :||||...:|:.|...:..:..:.:..|.  |......:..|......||.|.||:||..::...
  Fly   131 ITPAFHFNILQDFHEVMNENSTKFIKHLKTVAAGDNIFDFQEQAHYLTLDVICDTAMGVSINAME 195

  Fly   189 VDHSPIIQAFHLSSKLLFKRMINPLLSSDWIFQRTQLWRDLDEQLQVIHSQMESVIEKRAKELLD 253
            ...|.|:|||......:..|..:||..::.:::....:......|:.:......:|.||. |...
  Fly   196 NRSSSIVQAFKDMCYNINMRAFHPLKRNELLYRLAPDYPAYSRTLKTLQDFTNEIIAKRI-EAHK 259

  Fly   254 MGEPAGRAHN--------LLDTLLLAKFEGQSLSRREIRDEINTFVFAGVDTTTAAMSFVLYALA 310
            .|..:..|.:        .|||||.:..:|:.|:.:|:.:|::||:|.|.||||:.:||.:|.|:
  Fly   260 SGAVSTNAGDEFTRKKMAFLDTLLSSTIDGRPLNSKELYEEVSTFMFEGHDTTTSGVSFAVYLLS 324

  Fly   311 KFPETQTRLRKELQDVALDETTDLDA----LNGLPYLEALIKEVLRLYTIVPTTGRQTTQSTEIG 371
            :..:.|.:|.||.::|..:.....||    ::.:.||:..|||..|:|..||..||.|.:...|.
  Fly   325 RHQDEQRKLFKEQREVMGNSELGRDATFQEISQMKYLDLFIKEAQRVYPSVPFIGRFTEKDYVID 389

  Fly   372 GRTYCAGVTLWINMYGLAHDKEYYPDPYAFKPERWLPEDGAVAPPAFSYIPFSGGPHVCIGRRYS 436
            |.....|.||.:.:..|.::::.:.||:.|:|||:..|    .|..|.|:|||.||..|||::::
  Fly   390 GDLVPKGTTLNLGLVMLGYNEKVFKDPHKFRPERFELE----KPGPFEYVPFSAGPRNCIGQKFA 450

  Fly   437 LLLMKLLTARLVREFQM-----EL-----------------SPEQAPLR------LEAQMVLKAQ 473
            ||.:|.:.::::|.|::     ||                 ..::.|.|      |.|.:.||::
  Fly   451 LLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTIGLPDAERKKRDPYRHKYDPILSAVLTLKSE 515

  Fly   474 QGINV 478
            .|:.:
  Fly   516 NGLYI 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp311a1	NP_572780.3	p450	30..480	CDD:278495	138/492 (28%)
Cyp4e2	NP_001286196.1	p450	35..469	CDD:278495	129/438 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	8	7.960