DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp311a1 and Cyp4ac1

DIOPT Version :9

Sequence 1:	NP_572780.3	Gene:	Cyp311a1 / 32170	FlyBaseID:	FBgn0030367	Length:	483	Species:	Drosophila melanogaster
Sequence 2:	NP_608916.1	Gene:	Cyp4ac1 / 33754	FlyBaseID:	FBgn0031693	Length:	509	Species:	Drosophila melanogaster

Alignment Length:	521	Identity:	154/521 - (29%)
Similarity:	262/521 - (50%)	Gaps:	54/521 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LW------PLLLITLTIWI--LVRKWTLLRL--------GSSL-------PGPWAFPLLGNAQMV 44
            :|      |:||..||:.:  :.:.:.:|.|        ||.|       ||...|   ||...:
  Fly     1 MWIALLGIPILLAVLTLLLKHINKTYFILSLTKRVRTEDGSPLESKVAIMPGKTRF---GNNLDI 62

  Fly    45 GKLRPEYIFLVFTELRDRFGATYRLRLGPQLWVFLHS----------AEETRQALHDPTLRKADT 99
            ....|..:|....|      :|.:.:....||.||::          |||..|:  ...:.|...
  Fly    63 LNFTPASVFNFVRE------STAKAKGQNYLWYFLYAPMYNVVRPEEAEEVFQS--TKLITKNVV 119

  Fly   100 FMQLEPLIGNGLLISHGAHWTRQRRLLTPAFQPQLLRSFAPAIGGHVERLVGRLGATRGAFLEVT 164
            :..:.|.:|:|||||....|..:|:.|||||...:|:||........::.:..|.....|.||:.
  Fly   120 YELIRPFLGDGLLISTDHKWHSRRKALTPAFHFNVLQSFLGIFKEECKKFLNVLEKNLDAELELN 184

  Fly   165 EPLFACLLDAIVDTSMGAQLDTQSVDHSPIIQAFHLSSKLLFKRMINPLLSSDWIFQRTQLWRDL 229
            :.:....|:.|.:|::|.:||..| :.:...:|.|...::|.:|:.|||:..:|.|.....:|..
  Fly   185 QVIPPFTLNNICETALGVKLDDMS-EGNEYRKAIHAIEEVLIQRVCNPLMYYNWYFFVYGDYRKH 248

  Fly   230 DEQLQVIHSQMESVIEKRAKEL--LDMGE--PAGR--AHNLLDTLLLAKFEGQSLSRREIRDEIN 288
            .:.|:::|.....:||::.::.  ..:||  ..||  .:.:|||||.|:.:|| :..:.|.||:|
  Fly   249 LQNLRIVHDFSSRIIERKRQQFQQKQLGEVDEFGRKQRYAMLDTLLAAEADGQ-IDHQGICDEVN 312

  Fly   289 TFVFAGVDTTTAAMSFVLYALAKFPETQTRLRKELQDVALD-ETTDLDALNGLPYLEALIKEVLR 352
            ||:|.|.|||:..:.|.|..||...:.|.:..:|::::..| :...:...|.|.|||.:|||.||
  Fly   313 TFMFEGYDTTSTCLIFTLLMLALHEDVQKKCYEEVENLPEDSDDISMFQFNKLVYLECVIKESLR 377

  Fly   353 LYTIVPTTGRQTTQSTEIGGRTYCAGVTLWINMYGLAHDKEYYPDPYAFKPERWLPEDGAVAPPA 417
            ::..||..|||..:.|.:.|........:.|::|.:..|..::|.|..|:|:|:|||:.....|
  Fly   378 MFPSVPFIGRQCVEETVVNGMVMPKDTQISIHIYDIMRDPRHFPKPDLFQPDRFLPENTVNRHP- 441

  Fly   418 FSYIPFSGGPHVCIGRRYSLLLMKLLTARLVREFQMELSPEQAPLRLEAQMVLKAQQGINVSFLK 482
            |:|:|||.|...|||:::::|.||:|.|.::|.|::..:.:...|..|..:||:.|:.|.|...|
  Fly   442 FAYVPFSAGQRNCIGQKFAILEMKVLLAAVIRNFKLLPATQLEDLTFENGIVLRTQENIKVKLSK 506

  Fly   483 Q 483
            :
  Fly   507 R 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp311a1	NP_572780.3	p450	30..480	CDD:278495	142/466 (30%)
Cyp4ac1	NP_608916.1	p450	86..504	CDD:278495	133/422 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	7	7.060