DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp311a1 and Cyp4s3

DIOPT Version :9

Sequence 1:	NP_572780.3	Gene:	Cyp311a1 / 32170	FlyBaseID:	FBgn0030367	Length:	483	Species:	Drosophila melanogaster
Sequence 2:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster

Alignment Length:	506	Identity:	157/506 - (31%)
Similarity:	255/506 - (50%)	Gaps:	53/506 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLLITLTIWILVRKW--------TLLRLGSSLPGPWAFPLLGNAQMVGKLRPEYIFLVFTELRDR 62
            |.|:...:|....::        .|.|...:||||....|:.|      ::...|.....|||::
  Fly     4 LALVAFVLWAAFLRYLPKILNFLRLQRFAKTLPGPTIGELIAN------VKKGEILNWLKELREK 62

  Fly    63 FGATYRLRLGPQLWVFLHSAEETRQAL-HDPTLRKADTFMQLEPLIGNGLLISHGAHWTRQRRLL 126
            .|..:|:..|..|.|.....|:.:|.| ::..|.|:..:..|||.:|.|||.:.|..|.|:|:||
  Fly    63 HGPVFRIWFGKDLMVMFTDPEDIKQLLGNNQLLTKSRNYELLEPWLGKGLLTNGGESWHRRRKLL 127

  Fly   127 TPAFQPQLLRSFAPAIGGHVERLVGRL-----GATRGAFLEVTEPLFACLLDAIVDTSMGAQLDT 186
            ||.|..::|..|...:..:...||.||     |.:...:..:|  |||  ||||.:|:||.:...
  Fly   128 TPGFHFRILSEFKEPMEENCRILVRRLRTKANGESFDIYPYIT--LFA--LDAICETAMGIKKHA 188

  Fly   187 QSVDHSPIIQAFHLSSKLLFKRMINPLLSSDWIFQRTQLWRDLDEQLQVIHSQMESVIEKRAKEL 251
            |....|..:||.....:::.|:..:.....:..|:.|:..::.:..|:|:|.:...||..|.::|
  Fly   189 QLQSDSEYVQAVQSICRVMHKQSFSFWQRLNVFFKHTKPGKEREAALKVLHDETNRVIRLRREQL 253

  Fly   252 L-------------DMGEPAGRAHNLLDTLLLAKFE-GQSLSRREIRDEINTFVFAGVDTTTAAM 302
            :             |:|  |.|....||.|||.:.| |..||..:||:|::||:|.|.|||::|:
  Fly   254 IQERNEWKPEAEQDDVG--AKRRLAFLDMLLLTQMEGGAELSDTDIREEVDTFMFEGHDTTSSAI 316

  Fly   303 SFVLYALAKFPETQTRLRKELQDVALDETTDLDA--LNGLPYLEALIKEVLRLYTIVPTTGRQTT 365
            :|.|..|:|.|:.|.|        |.:|.::|:.  ...:|||||:|||.||:|..||...|:..
  Fly   317 AFALSLLSKNPDVQQR--------AFEEASELEGREKESMPYLEAVIKETLRIYPSVPFFSRKVL 373

  Fly   366 QSTEIGGRTYCAGVTLWINMYGLAHDKEYYPDPYAFKPERWLPEDGAVAPPAFSYIPFSGGPHVC 430
            :..|:|..|...|.::...:|.|..|.:.:|||..|.|:|:|..:..:.|  |::..||.||..|
  Fly   374 EDLEVGKLTVPKGASISCLIYMLHRDPKNFPDPERFDPDRFLVNEKQMHP--FAFAAFSAGPRNC 436

  Fly   431 IGRRYSLLLMKLLTARLVREFQMELSPEQAPLRLEAQMVLKAQQGINVSFL 481
            ||:::::|.:|...|.|:|.::.....:..|..| |::|.|:..||.:..|
  Fly   437 IGQKFAMLELKTSLAMLLRSYRFLPDKDHQPKPL-AELVTKSGNGIRLRIL 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp311a1	NP_572780.3	p450	30..480	CDD:278495	150/471 (32%)
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	145/455 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	8	7.960