DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp311a1 and Cyp4ae1

DIOPT Version :9

Sequence 1:	NP_572780.3	Gene:	Cyp311a1 / 32170	FlyBaseID:	FBgn0030367	Length:	483	Species:	Drosophila melanogaster
Sequence 2:	NP_525044.1	Gene:	Cyp4ae1 / 31193	FlyBaseID:	FBgn0015036	Length:	496	Species:	Drosophila melanogaster

Alignment Length:	504	Identity:	162/504 - (32%)
Similarity:	245/504 - (48%)	Gaps:	47/504 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LLITLTIWILVRKW--TLLRLG---------SSLPGPWAFPLLGNAQMVGKLRPEYIFLVFTELR 60
            :|:.|.:.:||.:.  :|.||.         ..:|.....||||.|..:...:|:.:...|.|..
  Fly     1 MLVVLLVALLVTRLVASLFRLALKELRHPLQGVVPSVSRVPLLGAAWQMRSFQPDNLHDKFAEYV 65

  Fly    61 DRFGATYRLRLGPQLWVFLHSAEETR------QALHDPTLRKADTFMQLEPLIGNGLLISHGAHW 119
            .|||.::   :|..|...:....|.|      |..|.  |:|...:..|...:|:|||:|.|..|
  Fly    66 KRFGRSF---MGTVLGHVVMVTAEPRHIDALLQGQHQ--LKKGTMYFALRGWLGDGLLLSRGKEW 125

  Fly   120 TRQRRLLTPAFQPQLLRSFAPAIGGHVERLVGRLGATRGAFLEVTE--PLFA-CLLDAIVDTSMG 181
            ...|:::||.|...:|..|..........||.|| .|.....||..  ||.. ..||.|.:|:||
  Fly   126 HTMRKIITPTFHFSILEQFVEVFDRQSSILVERL-RTLSYGNEVVNIYPLVGLAALDIITETAMG 189

  Fly   182 AQLDTQSVDHSPIIQAFHLSSKLLFKRMINPLLSSDWIFQRTQLW----RDLDEQLQVIHSQMES 242
            ..:|.|..| |.::.|....:.:|..|.:.|.|....:|:  ..|    |.....:..:|.....
  Fly   190 VNVDAQGAD-SEVVHAVKDLTNILATRFMRPHLLFPHLFR--LCWPSGFRKQQAGVICLHEFTNG 251

  Fly   243 VIEKRAKEL---LDMGEPAGRAHNLLDTLLLAKFEGQSLSRREIRDEINTFVFAGVDTTTAAMSF 304
            :||:|.:.|   .:..:|. :.|.||||||.|..:||.|:.::||||:|||:|.|.||||:|:||
  Fly   252 IIEQRRRLLAREANQDKPT-KPHALLDTLLRATVDGQPLTDKQIRDEVNTFIFEGHDTTTSAVSF 315

  Fly   305 VLYALAKFPETQTRLRKEL-----QDVALDETTDLDALNGLPYLEALIKEVLRLYTIVPTTGRQT 364
            .||.|::....|.:|.:||     ||  |.....|.....||||..::||.||||..:|...|..
  Fly   316 CLYLLSRHEAVQQKLFEELRMHYGQD--LFRGVILSDFATLPYLSCVVKESLRLYPPIPAVARCL 378

  Fly   365 TQSTEIGGRTYCAGVTLWINMYGLAHDKEYYPDPYAFKPERWLPEDGAVAPPAFSYIPFSGGPHV 429
            .:...|.......|..:.:.::.|..|:..:.||..|:|||.|.|:.....| :||||||.||..
  Fly   379 EKDLVIDEGYIPVGTNVVVLLWQLLRDEAIFTDPLVFQPERHLGEEAPRLSP-YSYIPFSAGPRN 442

  Fly   430 CIGRRYSLLLMKLLTARLVREFQMELSPEQAPLRLEAQMVLKAQQGINV 478
            |||::::||.||.:..:::|.:|  |.|..|.:....::||:::.|:||
  Fly   443 CIGQKFALLEMKTMVTKVIRHYQ--LLPMGADVEPSIKIVLRSKSGVNV 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp311a1	NP_572780.3	p450	30..480	CDD:278495	155/470 (33%)
Cyp4ae1	NP_525044.1	p450	35..486	CDD:278495	152/465 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	1	0.950	-	0	Normalized mean entropy	S4824
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	9	8.910