DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp311a1 and Cyp4a3

DIOPT Version :9

Sequence 1:	NP_572780.3	Gene:	Cyp311a1 / 32170	FlyBaseID:	FBgn0030367	Length:	483	Species:	Drosophila melanogaster
Sequence 2:	XP_038965516.1	Gene:	Cyp4a3 / 298423	RGDID:	631356	Length:	511	Species:	Rattus norvegicus

Alignment Length:	508	Identity:	151/508 - (29%)
Similarity:	247/508 - (48%)	Gaps:	58/508 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLLITLTIWILVRKWTLLRLGS--SLPGPWAFPLLGNAQMVGKLRPEYIFLVFTELRDRFGATYR 68
            |:|.....:.|.|:|.|..|..  |.|..|   |.|:     .|:......|.|.:....||..:
  Rat    29 LVLFKAVQFYLRRQWLLKALEKFPSTPSHW---LWGH-----DLKDREFQQVLTWVEKFPGACLQ 85

  Fly    69 LRLGPQLWVFLHSAEETRQALHDP-----TLRKAD-----TFMQLEPLI----GNGLLISHGAHW 119
                   |:   |..:||..|:||     .|.::|     .:..|.|.|    |.|||:.:|..|
  Rat    86 -------WL---SGSKTRVLLYDPDYVKVVLGRSDPKASGIYQFLAPWIVSGTGYGLLLLNGKKW 140

  Fly   120 TRQRRLLTPAFQPQLLRSFAPAIGGHVERLVGRLGA--TRGAFLEVTEPLFACLLDAIVDTSM-- 180
            .:..|:|||||...:|:.:...:...|..::.:...  .:...||:...:....||.::..:.
  Rat   141 FQHWRMLTPAFHYGILKPYVKIMADSVSIMLDKWEKLDDQDHPLEIFHYVSLMTLDTVMKCAFSH 205

  Fly   181 --GAQLDTQSVDHSPIIQAFHLSSKLLFKRMINPLLSSDWIFQRTQLWRDLDEQLQVIHSQMESV 243
              ..|||..|..::..::..   :.|.|.|:.:....:..|:..:...|......|:.|...:.|
  Rat   206 QGSVQLDVNSRSYTKAVEDL---NNLTFFRVRSAFYGNSIIYNMSSDGRLSRRACQIAHEHTDGV 267

  Fly   244 IEKRAKELL---DMGEPAGRAH-NLLDTLLLAKFE-GQSLSRREIRDEINTFVFAGVDTTTAAMS 303
            |:.|..:|.   ::.:...:.| :.||.||.||.| |:|||..::|.|::||:|.|.|||.:.:|
  Rat   268 IKMRKAQLQNEEELQKARKKRHLDFLDILLFAKMEDGKSLSDEDLRAEVDTFMFEGHDTTASGIS 332

  Fly   304 FVLYALAKFPETQTRLRKELQDVALDETT-DLDALNGLPYLEALIKEVLRLYTIVPTTGRQ-TTQ 366
            :|.||||..||.|.|.|:|:|.:..|.|: ..|.|:.:.|....|||.||||..||:..|: ::.
  Rat   333 WVFYALATHPEHQERCREEVQSILGDGTSVTWDHLDQISYTTMCIKEALRLYPPVPSVSRELSSP 397

  Fly   367 STEIGGRTYCAGVTLWINMYGLAHDKEYYPDPYAFKPERWLPEDGAVAPPAFS--YIPFSGGPHV 429
            .|...||:...|:|..|.:|||.|:..|:|:|..|.|.|:.|:.     |..|  |:|||||...
  Rat   398 VTFPDGRSIPKGITTTILIYGLHHNPSYWPNPKVFDPSRFSPDS-----PRHSHAYLPFSGGARN 457

  Fly   430 CIGRRYSLLLMKLLTARLVREFQMELSPEQAPLRLEAQMVLKAQQGINVSFLK 482
            |||:::::..:|:..|..:..|::...|.:.|:.: |::|||::.||::...|
  Rat   458 CIGKQFAMNELKVAVALTLLRFELLPDPTRIPVPM-ARLVLKSKNGIHLRLKK 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp311a1	NP_572780.3	p450	30..480	CDD:278495	142/478 (30%)
Cyp4a3	XP_038965516.1	CYP4B-like	69..506	CDD:410771	137/455 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910