DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp311a1 and Cyp4f5

DIOPT Version :9

Sequence 1:	NP_572780.3	Gene:	Cyp311a1 / 32170	FlyBaseID:	FBgn0030367	Length:	483	Species:	Drosophila melanogaster
Sequence 2:	NP_775147.1	Gene:	Cyp4f5 / 286905	RGDID:	708364	Length:	526	Species:	Rattus norvegicus

Alignment Length:	505	Identity:	161/505 - (31%)
Similarity:	243/505 - (48%)	Gaps:	41/505 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 WPLLLITLTIWILVR--KWTL--------LRLGSSLP-GPWAFPLLGNAQMVGKLRPEYIFLVFT 57
            |.|||:....|||.|  .||.        ||.....| ..|....||..|.    ..|.:.|| |
  Rat    19 WHLLLLGAASWILARILAWTYSFCENCSRLRCFPQSPKRNWFLGHLGTIQS----NEEGMRLV-T 78

  Fly    58 ELRDRFGATYRLRLGPQLWVF-LHSAEETRQALHDPTL--RKADTFMQ-LEPLIGNGLLISHGAH 118
            |:...|...:...|||.:.|. |.........|..|.|  .|..||:: |:|.:|:||.:|.|..
  Rat    79 EMGQTFRDIHLCWLGPVIPVLRLVDPAFVAPLLQAPALVAPKDTTFLRFLKPWLGDGLFLSSGDK 143

  Fly   119 WTRQRRLLTPAFQPQLLRSFAPAIGGHVERLVGR---LGATRGAFLEVTEPLFACLLDAIVDTSM 180
            |:|.||||||||...:|:.:.......|..:..:   |.....|.||:.|.:....||::.....
  Rat   144 WSRHRRLLTPAFHFDILKPYVKIFNQSVNIMHAKWKHLCLEGSARLEMFENISLMTLDSLQKCLF 208

  Fly   181 GAQLDTQSVDHSPIIQAFHLSSKLLFKRMINPLLSSDWIFQRTQLWRDLDEQLQVIHSQMESVIE 245
            |...:.|......|.....||| |:.||.....|..|:::.||...|...:...::|:..::||.
  Rat   209 GFDSNCQESPSEYISAILELSS-LIIKRSQQLFLYLDFLYYRTADGRRFRKACDLVHNFTDAVIR 272

  Fly   246 KRAKELLDMG---------EPAGRAHNLLDTLLLAKFE-GQSLSRREIRDEINTFVFAGVDTTTA 300
            :|.:.|...|         :...:..:.:|.|||||.| |:.||..:||.|.:||:|.|.|||.:
  Rat   273 ERRRLLSSQGTDEFLESKTKSKSKTLDFIDVLLLAKDEHGKELSDEDIRAEADTFMFGGHDTTAS 337

  Fly   301 AMSFVLYALAKFPETQTRLRKELQDVALD---ETTDLDALNGLPYLEALIKEVLRLYTIVPTTGR 362
            |:|::||.||:.||.|.|.|:|:.::..|   |..:.|.|..||:|...|||.|||:.......|
  Rat   338 ALSWILYNLARHPEYQERCRQEVWELLRDREPEEIEWDDLAQLPFLTMCIKESLRLHPPAIDLLR 402

  Fly   363 QTTQSTEI-GGRTYCAGVTLWINMYGLAHDKEYYPDPYAFKPERWLPEDGAVAPPAFSYIPFSGG 426
            :.||...: .||....|....|:::|:.|:...:|||..|.|.|:..|:.....| .|:||||.|
  Rat   403 RCTQDIVLPDGRVIPKGNICVISIFGIHHNPSVWPDPEVFDPFRFDSENRQKRSP-LSFIPFSAG 466

  Fly   427 PHVCIGRRYSLLLMKLLTARLVREFQMELSPEQAPLRLEAQMVLKAQQGI 476
            |..|||:.:::..||::.|..:..|:  :.|:....|.:.:::|:|:.|:
  Rat   467 PRNCIGQTFAMNEMKVVVALTLLRFR--VLPDDKEPRRKPEIILRAEGGL 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp311a1	NP_572780.3	p450	30..480	CDD:278495	149/469 (32%)
Cyp4f5	NP_775147.1	p450	52..516	CDD:278495	149/472 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.810