DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp311a1 and CYP4V2

DIOPT Version :9

Sequence 1:	NP_572780.3	Gene:	Cyp311a1 / 32170	FlyBaseID:	FBgn0030367	Length:	483	Species:	Drosophila melanogaster
Sequence 2:	NP_997235.3	Gene:	CYP4V2 / 285440	HGNCID:	23198	Length:	525	Species:	Homo sapiens

Alignment Length:	517	Identity:	165/517 - (31%)
Similarity:	258/517 - (49%)	Gaps:	55/517 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LWPLLLI------------TLTIWIL------VRKWTLLRLGSSLPGPW---AFPLLGNAQMVGK 46
            :|..||:            :|.:.:|      .|||..:|     |.|.   |:||:|:|.::..
Human     9 VWQKLLLWGAASALSLAGASLVLSLLQRVASYARKWQQMR-----PIPTVARAYPLVGHALLMKP 68

  Fly    47 LRPEYI--FLVFTELRDRFGATYRLRLGPQLWVFLHSAEETRQAL-HDPTLRKADTFMQLEPLIG 108
            ...|:.  .:.:|| ..|.....:|.:||...|.|::||.....| ....:.|:..:..|||.:|
Human    69 DGREFFQQIIEYTE-EYRHMPLLKLWVGPVPMVALYNAENVEVILTSSKQIDKSSMYKFLEPWLG 132

  Fly   109 NGLLISHGAHWTRQRRLLTPAFQPQLLRSFAPAIGGHVERLVGRL-----GATRGAFLEVTEPLF 168
            .|||.|.|..|..:|::|||.|...:|..|...:......||.:|     ......|..:|
Human   133 LGLLTSTGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLEKHINQEAFNCFFYIT---- 193

  Fly   169 ACLLDAIVDTSMGAQLDTQSVDHSPIIQAFHLSSKLLFKRMINPLLSSD-WIFQRTQLWRDLDEQ 232
            .|.||.|.:|:||..:..||.|.|..::|.:..|:::|:|:..|.|..| |.....:.| :..:.
Human   194 LCALDIICETAMGKNIGAQSNDDSEYVRAVYRMSEMIFRRIKMPWLWLDLWYLMFKEGW-EHKKS 257

  Fly   233 LQVIHSQMESVIEKRAKELLD----MGEPAGRAHN------LLDTLL-LAKFEGQSLSRREIRDE 286
            ||::|:...|||.:||.|:..    .|:..|.|.:      .||.|| :...||..||..:||:|
Human   258 LQILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRRAFLDLLLSVTDDEGNRLSHEDIREE 322

  Fly   287 INTFVFAGVDTTTAAMSFVLYALAKFPETQTRLRKELQDV--ALDETTDLDALNGLPYLEALIKE 349
            ::||:|.|.|||.||:::.||.|...||.|.::..||.||  ..|....::.|..|.|||.:|||
Human   323 VDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKSDRPATVEDLKKLRYLECVIKE 387

  Fly   350 VLRLYTIVPTTGRQTTQSTEIGGRTYCAGVTLWINMYGLAHDKEYYPDPYAFKPERWLPEDGAVA 414
            .|||:..||...|..::..|:.|.....|....|..|.|..|..|:|:|..|:|||:.||:....
Human   388 TLRLFPSVPLFARSVSEDCEVAGYRVLKGTEAVIIPYALHRDPRYFPNPEEFQPERFFPENAQGR 452

  Fly   415 PPAFSYIPFSGGPHVCIGRRYSLLLMKLLTARLVREFQMELSPEQAPLRLEAQMVLKAQQGI 476
            .| ::|:|||.||..|||::::::..|.:.:.::|.|.:|.:.::..|.||.|::|:...||
Human   453 HP-YAYVPFSAGPRNCIGQKFAVMEEKTILSCILRHFWIESNQKREELGLEGQLILRPSNGI 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp311a1	NP_572780.3	p450	30..480	CDD:278495	156/472 (33%)
CYP4V2	NP_997235.3	p450	55..517	CDD:278495	154/466 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.910