DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp311a1 and CYP4A22

DIOPT Version :9

Sequence 1:	NP_572780.3	Gene:	Cyp311a1 / 32170	FlyBaseID:	FBgn0030367	Length:	483	Species:	Drosophila melanogaster
Sequence 2:	NP_001010969.2	Gene:	CYP4A22 / 284541	HGNCID:	20575	Length:	519	Species:	Homo sapiens

Alignment Length:	502	Identity:	154/502 - (30%)
Similarity:	248/502 - (49%)	Gaps:	55/502 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLLITLTIWILVRKWTLLRLGSSLPGPWAFPLLGNAQMVGKLRPEYIFLVFTELRDRFGATYRLR 70
            ||||......|.|:| ||:.....|.|.:..|.|:.|            .|...::......|::
Human    29 LLLIKAAQLYLHRQW-LLKALQQFPCPPSHWLFGHIQ------------EFQHDQELQRIQERVK 80

  Fly    71 LGPQ---LWVFLHSAEETRQALHDPTLRKA----------DTFMQLEPLIGNGLLISHGAHWTRQ 122
            ..|.   .|::   ..:.|..|:||...|.          .::..|.|.||.|||:.:|..|.:.
Human    81 TFPSACPYWIW---GGKVRVQLYDPDYMKVILGRSDPKSHGSYKFLAPRIGYGLLLLNGQTWFQH 142

  Fly   123 RRLLTPAFQPQLLRSFAPAIGGHV-------ERLVGRLGATRGAFLEVTEPLFACLLDAIVDTSM 180
            ||:|||||...:|:.:...:...|       |.|:|     :.:.|||.:.:....||.|:.::.
Human   143 RRMLTPAFHNDILKPYVGLMADSVRVMLDKWEELLG-----QDSPLEVFQHVSLMTLDTIMKSAF 202

  Fly   181 GAQLDTQSVDHS--PIIQAFHLSSKLLFKRMINPLLSSDWIFQRTQLWRDLDEQLQVIHSQMESV 243
            ..|...| ||.:  ..|||....:.|:|..|.|....:|.|:..|...|......|:.|...:.|
Human   203 SHQGSIQ-VDRNSQSYIQAISDLNSLVFCCMRNAFHENDTIYSLTSAGRWTHRACQLAHQHTDQV 266

  Fly   244 IEKRAKELLDMGE----PAGRAHNLLDTLLLAKFE-GQSLSRREIRDEINTFVFAGVDTTTAAMS 303
            |:.|..:|...||    ...|..:.||.|||||.| |..||.:::|.|::||:|.|.|||.:.:|
Human   267 IQLRKAQLQKEGELEKIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGIS 331

  Fly   304 FVLYALAKFPETQTRLRKELQDVALD-ETTDLDALNGLPYLEALIKEVLRLYTIVPTTGRQ-TTQ 366
            ::|||||..|:.|.|.|:|:..:..| .:...:.|:.:||....|||.||||..||..||: :|.
Human   332 WILYALATHPKHQERCREEIHGLLGDGASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTP 396

  Fly   367 STEIGGRTYCAGVTLWINMYGLAHDKEYYPDPYAFKPERWLPEDGAVAPPAFSYIPFSGGPHVCI 431
            .|...||:...|:.:.:::|||.|:.:.:|:...|.|.|:.|   ..|..:.:::|||||...||
Human   397 VTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNLEVFDPSRFAP---GSAQHSHAFLPFSGGSRNCI 458

  Fly   432 GRRYSLLLMKLLTARLVREFQMELSPEQAPLRLEAQMVLKAQQGINV 478
            |:::::..:|:..|..:..|::...|.:.|:.: |::|||::.||::
Human   459 GKQFAMNQLKVARALTLLRFELLPDPTRIPIPM-ARLVLKSKNGIHL 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp311a1	NP_572780.3	p450	30..480	CDD:278495	145/478 (30%)
CYP4A22	NP_001010969.2	p450	52..505	CDD:278495	145/478 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.810