DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp311a1 and Cyp4f6

DIOPT Version :9

Sequence 1:	NP_572780.3	Gene:	Cyp311a1 / 32170	FlyBaseID:	FBgn0030367	Length:	483	Species:	Drosophila melanogaster
Sequence 2:	XP_006241111.1	Gene:	Cyp4f6 / 266689	RGDID:	708365	Length:	538	Species:	Rattus norvegicus

Alignment Length:	515	Identity:	150/515 - (29%)
Similarity:	234/515 - (45%)	Gaps:	72/515 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 LRLGSSLPGPWAFPLLGNAQMVGKLRPEYIFLVFTELRDRFGATYRLRLGPQ----LWVFLH--- 80
            |.:||....||...|||.|..:......:|:..:..       ..|||..||    .|.:.|
  Rat    10 LGMGSLTASPWHLLLLGGASWILARILAWIYTFYDN-------CCRLRCFPQPPKPSWFWGHLTL 67

  Fly    81 --SAEETRQALHD-----------------PTLR--------------------KADTFMQLEPL 106
              :.||..|.:..                 |.||                    :...:..|:|.
  Rat    68 MKNNEEGMQFIAHLGRNFRDIHLSWVGPVYPILRLVHPNVIAPLLQASAAVAPKEMTLYGFLKPW 132

  Fly   107 IGNGLLISHGAHWTRQRRLLTPAFQPQLLRSFAPAIGGHVERLVG---RLGATRGAFLEVTEPLF 168
            :|:|||:|.|..|...||||||||...:|:|:.......|..:..   ||.|...|.|::.|.:.
  Rat   133 LGDGLLMSAGEKWNHHRRLLTPAFHFDILKSYVKIFNKSVNTMHAKWQRLTAKGSARLDMFEHIS 197

  Fly   169 ACLLDAIVDTSMGAQLDTQSVDHSPIIQAFHLSSKLLFKRMINPLLSSDWIFQRTQLWRDLDEQL 233
            ...||::.........:.|..:...|.....||| |:.||...|.|..|:::..|...|...:..
  Rat   198 LMTLDSLQKCIFSFDSNCQESNSEYIAAILELSS-LIVKRQRQPFLYLDFLYYLTADGRRFRKAC 261

  Fly   234 QVIHSQMESVIEKRAKELLDMG-------EPAGRAHNLLDTLLLAKFE-GQSLSRREIRDEINTF 290
            .|:|:..::||.:|...|...|       ....:..:.:|.|||||.| |:.||..:||.|.:||
  Rat   262 DVVHNFTDAVIRERRSTLNTQGVDEFLKARAKTKTLDFIDVLLLAKDEHGKGLSDVDIRAEADTF 326

  Fly   291 VFAGVDTTTAAMSFVLYALAKFPETQTRLRKELQDVALD---ETTDLDALNGLPYLEALIKEVLR 352
            :|.|.|||.:|:|::||.||:.||.|.|.|:|::::..|   |..:.|.|..||:|...|||.||
  Rat   327 MFGGHDTTASALSWILYNLARHPEYQERCRQEVRELLRDREPEEIEWDDLAQLPFLTMCIKESLR 391

  Fly   353 LYTIVPTTGRQTTQSTEI-GGRTYCAGVTLWINMYGLAHDKEYYPDPYAFKPERWLPEDGAVAPP 416
            |:..|....|..:|...: .||....|....|:::|:.|:...:|||..:.|.|:.||:.....|
  Rat   392 LHPPVLLISRCCSQDIVLPDGRVIPKGNICVISIFGVHHNPSVWPDPEVYNPFRFDPENPQKRSP 456

  Fly   417 AFSYIPFSGGPHVCIGRRYSLLLMKLLTARLVREFQMELSPEQAPLRLEAQMVLKAQQGI 476
             .::||||.||..|||:.:::..:|:..|..:..|.  :.|:....|.:.:::|:|:.|:
  Rat   457 -LAFIPFSAGPRNCIGQTFAMSEIKVALALTLLRFC--VLPDDKEPRRKPELILRAEGGL 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp311a1	NP_572780.3	p450	30..480	CDD:278495	147/508 (29%)
Cyp4f6	XP_006241111.1	p450	53..515	CDD:278495	137/465 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.810