DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp311a1 and CYP4X1

DIOPT Version :9

Sequence 1:	NP_572780.3	Gene:	Cyp311a1 / 32170	FlyBaseID:	FBgn0030367	Length:	483	Species:	Drosophila melanogaster
Sequence 2:	NP_828847.1	Gene:	CYP4X1 / 260293	HGNCID:	20244	Length:	509	Species:	Homo sapiens

Alignment Length:	484	Identity:	133/484 - (27%)
Similarity:	241/484 - (49%)	Gaps:	22/484 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 IWILVRKWTLLRLGSSLPGPWAFPLLGNAQMVGKLRPEYIFLVFTELRDRFGATYRLRLGP-QLW 76
            |.:.:|:..|||.....|.|.....||:.:.:.....|.:    .|:.:::...:...:|| |.:
Human    30 IKLYLRRQRLLRDLRPFPAPPTHWFLGHQKFIQDDNMEKL----EEIIEKYPRAFPFWIGPFQAF 90

  Fly    77 VFLHSAEETRQALH--DPTLRKADTFMQLEPLIGNGLLISHGAHWTRQRRLLTPAFQPQLLRSFA 139
            ..::..:..:..|.  ||..:....|.  .||:|.||....|..|.:.||||||.|...:|:::.
Human    91 FCIYDPDYAKTLLSRTDPKSQYLQKFS--PPLLGKGLAALDGPKWFQHRRLLTPGFHFNILKAYI 153

  Fly   140 PAIGGHVERLVG---RLGATRGAFLEVTEPLFACLLDAIVDTSMGAQLDTQ-SVDHSPIIQAFHL 200
            ..:...|:.::.   ::.:|:...:||.|.:.:..||.|:..:...:.:.| :..|.|..:|...
Human   154 EVMAHSVKMMLDKWEKICSTQDTSVEVYEHINSMSLDIIMKCAFSKETNCQTNSTHDPYAKAIFE 218

  Fly   201 SSKLLFKRMINPLLSSDWIFQRTQLWRDLDEQLQVIHSQMESVIEKRAKEL----LDMGEPAGRA 261
            .||::|.|:.:.|..||.||:.:.......:..:|::...:::|::|.|.|    .....|..:.
Human   219 LSKIIFHRLYSLLYHSDIIFKLSPQGYRFQKLSRVLNQYTDTIIQERKKSLQAGVKQDNTPKRKY 283

  Fly   262 HNLLDTLLLAKFE-GQSLSRREIRDEINTFVFAGVDTTTAAMSFVLYALAKFPETQTRLRKELQD 325
            .:.||.:|.||.| |.|.|..::..|::||:.||.||..|::|::||.||..||.|.|.|:|::.
Human   284 QDFLDIVLSAKDESGSSFSDIDVHSEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRG 348

  Fly   326 VALD-ETTDLDALNGLPYLEALIKEVLRLYTIVPTTGRQTTQS-TEIGGRTYCAGVTLWINMYGL 388
            :..| .:...|.|..:.|....|||..||...||:..|..::. |...|.|..||:|:.::::||
Human   349 ILGDGSSITWDQLGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWGL 413

  Fly   389 AHDKEYYPDPYAFKPERWLPEDGAVAPPAFSYIPFSGGPHVCIGRRYSLLLMKLLTARLVREFQM 453
            .|:...:.:|..|.|.|:..|:.....| ::|:|||.|...|||:.::::.:|:..|.::..|::
Human   414 HHNPAVWKNPKVFDPLRFSQENSDQRHP-YAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRV 477

  Fly   454 ELSPEQAPLRLEAQMVLKAQQGINVSFLK 482
            ...|.: ||......:||.:.|:.:...|
Human   478 TPDPTR-PLTFPNHFILKPKNGMYLHLKK 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp311a1	NP_572780.3	p450	30..480	CDD:278495	127/463 (27%)
CYP4X1	NP_828847.1	p450	47..501	CDD:306555	127/461 (28%)
CYP4X1	NP_828847.1	heme binding region	447..460		6/12 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	4	3.870