DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp311a1 and Cyp4a29

DIOPT Version :9

Sequence 1:	NP_572780.3	Gene:	Cyp311a1 / 32170	FlyBaseID:	FBgn0030367	Length:	483	Species:	Drosophila melanogaster
Sequence 2:	NP_001093653.1	Gene:	Cyp4a29 / 230639	MGIID:	3717143	Length:	509	Species:	Mus musculus

Alignment Length:	499	Identity:	151/499 - (30%)
Similarity:	246/499 - (49%)	Gaps:	42/499 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLLITLTIWILVRKWTLLRLGSSLPGPWAFPLLGNAQMVGKLRPEYIFLVFTELR------DRF- 63
            |||.......|.|:| |||.....|.|.:..|.|:...         |.|..|||      ::|
Mouse    29 LLLFKAAQHYLRRQW-LLRALYQFPSPPSHWLFGHCLQ---------FKVDEELRWILRYLEKFP 83

  Fly    64 GATYRLRLGPQLWVFLHSAEETRQAL--HDPTLRKADTFMQLEPLIGNGLLISHGAHWTRQRRLL 126
            ||......|..:::.:...:..:..|  .||   ||..:..|.|.:|:||...:|..|.:.||||
Mouse    84 GAFLHWIWGSHVFIKVCDPDYMKVILGRADP---KASLYRFLTPWLGHGLFFLNGDEWFQHRRLL 145

  Fly   127 TPAFQPQLLRSFAPAIGGHVERLVGRLG--ATRGAFLEVTEPLFACLLDAIVDTSM----GAQLD 185
            ||||...:|:.:...:...|:.::.:..  |.:...||:..|:...:||.|:..:.    ..|||
Mouse   146 TPAFHYDILKPYVGIMADSVQVMLEKWEQIACQDITLEIFHPISLMMLDTIMKYAFSYQGSVQLD 210

  Fly   186 TQSVDHSPIIQAFHLSSKLLFKRMINPLLSSDWIFQRTQLWRDLDEQLQVIHSQMESVIEKRAKE 250
            ..|   ...:||....:.|:..||.|..|.:|.|:..|...|..:...|:.|...:.|::.|..:
Mouse   211 RSS---QAYLQAVSDLNNLVTSRMKNVFLHNDIIYNLTSHSRRTNSACQIAHEHTDRVVKLRKAQ 272

  Fly   251 LLD---MGEPAG-RAHNLLDTLLLAKF-EGQSLSRREIRDEINTFVFAGVDTTTAAMSFVLYALA 310
            |.|   |.:..| |..:.||.|||::. :|.|||.:.:|.|:::.:|.|.||..:.:|:|.||||
Mouse   273 LQDNKSMKKLRGKRCLDFLDILLLSRMDDGSSLSDKALRAEVDSLMFGGHDTPASGISWVFYALA 337

  Fly   311 KFPETQTRLRKELQDVALD-ETTDLDALNGLPYLEALIKEVLRLYTIVPTTGRQ-TTQSTEIGGR 373
            ..|:.|.|.|:|:|.:..| .....|.|:.:||....|||.||||..:|:.||: :|..|...||
Mouse   338 THPDHQQRCREEVQSLLGDGSPITWDHLHQMPYTTMCIKEALRLYPPIPSVGRKLSTPVTFPDGR 402

  Fly   374 TYCAGVTLWINMYGLAHDKEYYPDPYAFKPERWLPEDGAVAPPAFSYIPFSGGPHVCIGRRYSLL 438
            :...|:|:.::.|.|.|:.:.:|:|..|.|.|:....   ...:.:::|||||...|||:..::.
Mouse   403 SLPKGITVLLHFYALHHNPKVWPNPEVFDPSRFAMNS---VQHSHAFLPFSGGSRNCIGKHLAMN 464

  Fly   439 LMKLLTARLVREFQMELSPEQAPLRLEAQMVLKAQQGINVSFLK 482
            ::|:..|..:..|::...|.:.|:..: |:|||::.||.:...|
Mouse   465 VLKVAVALTLLRFELLPDPSRVPIPTQ-QLVLKSKNGIYLHLRK 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp311a1	NP_572780.3	p450	30..480	CDD:278495	141/471 (30%)
Cyp4a29	NP_001093653.1	p450	52..503	CDD:278495	141/469 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.810