DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp311a1 and Cyp4f17

DIOPT Version :9

Sequence 1:	NP_572780.3	Gene:	Cyp311a1 / 32170	FlyBaseID:	FBgn0030367	Length:	483	Species:	Drosophila melanogaster
Sequence 2:	NP_001094915.1	Gene:	Cyp4f17 / 208285	MGIID:	3646233	Length:	524	Species:	Mus musculus

Alignment Length:	530	Identity:	161/530 - (30%)
Similarity:	250/530 - (47%)	Gaps:	93/530 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 LLRLGSSL----PG---PWAFPLLGNAQMVGKLRPEYIFL--VFTELRDRFGATYRLRLGPQ--- 74
            :|:||.|.    ||   ||..     .|:||    ..:||  :.|.:...:....|||..|:
Mouse     1 MLQLGLSWLGLGPGAAFPWQL-----LQLVG----ASLFLARILTWICAFYDNYCRLRCFPEPPS 56

  Fly    75 -LWVFLHSA-----EETRQAL-------HD----------PTLR-------------------KA 97
             .|.:.|.:     ||..|.|       ||          |.||                   |.
Mouse    57 RHWFWGHMSMVKNNEEGLQLLTERSHQFHDVHLCWIGPFYPILRLIHPKFIGPILQASAAVAPKE 121

  Fly    98 DTFMQ-LEPLIGNGLLISHGAHWTRQRRLLTPAFQPQLLRSFAPAIGGHV-------ERLVGRLG 154
            ..|.. |:|.:|:|||:|.|..|:|.|.||||||...:|:.:.......|       :||
Mouse   122 MIFYGFLKPWLGDGLLVSAGEKWSRHRHLLTPAFHFDILKPYMKNFNKSVNIMHAKWQRL----- 181

  Fly   155 ATRG-AFLEVTEPLFACLLDAIVDTSMGAQLDTQSVDHSPIIQAFHLSSKLLFKRMINPLLSSDW 218
            .|:| |.|::.|.:....||::.:.......:.|. ..|..|.|....|.|:.||...|.|..|:
Mouse   182 TTKGTACLDMLEHISLMTLDSLQNCVFSFDSNCQE-SPSEYIAAIQELSSLIVKRHHQPFLYLDF 245

  Fly   219 IFQRTQLWRDLDEQLQVIHSQMESVIEKRAKEL----LD---MGEPAGRAHNLLDTLLLAKFE-G 275
            ::..|...|...:...::|:..::||.:|.:.|    ||   ..:...:..:.:|.|||||.| |
Mouse   246 LYYCTADGRRFRKACDLVHNFTDAVIRERRRTLSSQNLDEFLKSKTKSKTLDFIDVLLLAKDEHG 310

  Fly   276 QSLSRREIRDEINTFVFAGVDTTTAAMSFVLYALAKFPETQTRLRKELQDVAL---DETTDLDAL 337
            :.||..:||.|.:||:|.|.|||.:|:|::||.||:.||.|.|.|:|:|::..   .:..:.|.|
Mouse   311 KELSDEDIRAEADTFMFGGHDTTASALSWILYNLARHPEYQERCRQEVQELLRGREPQEIEWDDL 375

  Fly   338 NGLPYLEALIKEVLRLYTIVPTTGRQTTQSTEI-GGRTYCAGVTLWINMYGLAHDKEYYPDPYAF 401
            ..||:|...|||.|||:..|....|..||...: .||....|....|:::|:.|:.|.:|||..:
Mouse   376 AQLPFLTMCIKESLRLHPPVTVISRCCTQDVVLPDGRVIPKGTDCVISIFGVHHNPEVWPDPEVY 440

  Fly   402 KPERWLPEDGAVAPPAFSYIPFSGGPHVCIGRRYSLLLMKLLTARLVREFQMELSPEQAPLRLEA 466
            .|.|:.||:.....| .::||||.||..|||:.:::..||:..|..:..|:: |..::.| |.:.
Mouse   441 DPFRFDPENPQKRSP-LAFIPFSAGPRNCIGQTFAMREMKVALALTLLRFRV-LPGDKEP-RRKP 502

  Fly   467 QMVLKAQQGI 476
            :::|:|:.|:
Mouse   503 ELILRAEGGL 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp311a1	NP_572780.3	p450	30..480	CDD:278495	157/518 (30%)
Cyp4f17	NP_001094915.1	p450	52..515	CDD:365848	144/470 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.810