Protein Alignment Cyp311a1 and CYP4Z1

DIOPT Version :10

• Sequence 1: NP_572780.3
• Gene: Cyp311a1 / 32170
• FlyBaseID: FBgn0030367
• Length: 483
• Species: Drosophila melanogaster
• Sequence 2: NP_835235.1
• Gene: CYP4Z1 / 199974
• HGNCID: 20583
• Length: 505
• Species: Homo sapiens
• Alignment Length: 511
• Identity: 150/511 - (29%)
• Similarity: 255/511 - (49%)
• Gaps: 55/511 - (10%)

  Fly     6 LLLITLTIWILV---------RKWTLLRLGSSLPGPWAFPLLGNAQMVGKLRPEYIFLVFTELRD 61
            ||||.|.:.:|:         |:| ::|.....|.|.|....|:.:..    |...|.|:.:|.:
Human    15 LLLILLCMSLLLFQVIRLYQRRRW-MIRALHLFPAPPAHWFYGHKEFY----PVKEFEVYHKLME 74

  Fly    62 RFGATYRLRLGPQLWVFLHSAEETRQALHDPTLRK----------ADTFMQLEPLIGNGLLISHG 116
            ::.....|.:||....|         ::|||...|          |.:...||..:|.||:...|
Human    75 KYPCAVPLWVGPFTMFF---------SVHDPDYAKILLKRQDPKSAVSHKILESWVGRGLVTLDG 130

  Fly   117 AHWTRQRRLLTPAFQPQLLRSFAPAIGGHVERLVGRL--GATRGAFLEVTEPLFACLLDAIVDTS 179
            :.|.:.|:::.|.|...:|:.|...:...|..::.:.  ...:.:.||:.:.:....||:|:..:
Human   131 SKWKKHRQIVKPGFNISILKIFITMMSESVRMMLNKWEEHIAQNSRLELFQHVSLMTLDSIMKCA 195

  Fly   180 MGAQ--LDTQSVDHSPIIQAFHLSSKLLFKRMINPLLSSDWIFQRTQLWRDLDEQLQVIHSQMES 242
            ...|  :...|...|.:...|:| ||:..:||.|.|..:|.:|:.:...:...:..|.:|...|.
Human   196 FSHQGSIQLDSTLDSYLKAVFNL-SKISNQRMNNFLHHNDLVFKFSSQGQIFSKFNQELHQFTEK 259

  Fly   243 VIEKRAKELLD---MGEPAGRAHNLLDTLLLAKFEG-QSLSRREIRDEINTFVFAGVDTTTAAMS 303
            ||:.|.:.|.|   ......|..:.||.||.||.|. :..|..:::.|:.||:|||.|||::|:|
Human   260 VIQDRKESLKDKLKQDTTQKRRWDFLDILLSAKSENTKDFSEADLQAEVKTFMFAGHDTTSSAIS 324

  Fly   304 FVLYALAKFPETQTRLRKELQDVALD-ETTDLDALNGLPYLEALIKEVLRLYTIVPTTGRQTTQS 367
            ::||.|||:||.|.|.|.|::::..| .:...:.|:.:||....|||.||||..|....|...:.
Human   325 WILYCLAKYPEHQQRCRDEIRELLGDGSSITWEHLSQMPYTTMCIKECLRLYAPVVNISRLLDKP 389

  Fly   368 -TEIGGRTYCAGVTLWINMYGLAHDKEYYPDPYAFKPERWLPEDGAVAPPAFSYIPFSGGPHVCI 431
             |...||:..||:|::||::.|.|:..::.||..|.|.|:..|:.....| :::||||.|...||
Human   390 ITFPDGRSLPAGITVFINIWALHHNPYFWEDPQVFNPLRFSRENSEKIHP-YAFIPFSAGLRNCI 453

  Fly   432 GRRYSLLLMKLLTARLVREFQMELSPEQA----PLRLEAQMVLKAQQGINVSFLKQ 483
            |:.::::..|:..|..:..|  :|:|:.:    |:|   |:|||::.||:| |.|:
Human   454 GQHFAIIECKVAVALTLLRF--KLAPDHSRPPQPVR---QVVLKSKNGIHV-FAKK 503

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp311a1	NP_572780.3	cytochrome_P450	64..478	CDD:477761	130/437 (30%)
CYP4Z1	NP_835235.1	CYP4B-like	66..500	CDD:410771	134/450 (30%)